{"id":"https://openalex.org/W2406084151","doi":null,"title":"The erbA/thyroid hormone receptor genes in development of the central nervous system.","display_name":"The erbA/thyroid hormone receptor genes in development of the central nervous system.","publication_year":1994,"publication_date":"1994-04-01","ids":{"openalex":"https://openalex.org/W2406084151","mag":"2406084151","pmid":"https://pubmed.ncbi.nlm.nih.gov/8061332"},"language":"en","primary_location":{"id":"pmid:8061332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8061332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in cancer biology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063573320","display_name":"Douglas Forrest","orcid":"https://orcid.org/0000-0002-3463-4162","observed_orcids":["https://orcid.org/0000-0002-3463-4162"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"D Forrest","raw_affiliation_strings":["Roche Institute of Molecular Biology, Nutley, NJ 07110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche Institute of Molecular Biology, Nutley, NJ 07110","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5063573320"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5978,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.82748716,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"5","issue":"2","first_page":"167","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-hormone-receptor","display_name":"thyroid hormone receptor","score":0.777999997138977},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.8479999899864197},{"id":"https://openalex.org/keywords/central-nervous-system-development","display_name":"central nervous system development","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nuclear-receptors","display_name":"nuclear receptors","score":0.8659999966621399},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.875},{"id":"https://openalex.org/keywords/developmental-gene-regulation","display_name":"developmental gene regulation","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C109115496","wikidata":"https://www.wikidata.org/wiki/Q2539644","display_name":"Thyroid hormone receptor","level":3,"score":0.7753686904907227},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.7650903463363647},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.662301778793335},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6398923397064209},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.6161787509918213},{"id":"https://openalex.org/C149574134","wikidata":"https://www.wikidata.org/wiki/Q18031987","display_name":"Thyroid hormone receptor beta","level":5,"score":0.6129189133644104},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.5878231525421143},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.5594757199287415},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5547533631324768},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5235024094581604},{"id":"https://openalex.org/C160860887","wikidata":"https://www.wikidata.org/wiki/Q18031986","display_name":"Thyroid hormone receptor alpha","level":5,"score":0.4548741579055786},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3860984444618225},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3554840087890625},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33456844091415405},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30889707803726196},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16129764914512634},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10025843977928162},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.05263683199882507},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011988","descriptor_name":"Receptors, Thyroid Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8061332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8061332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in cancer biology","raw_type":"Journal Article"},{"id":"mag:2406084151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8061332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2262002596","https://openalex.org/W2430997039","https://openalex.org/W4236637333","https://openalex.org/W2329729227","https://openalex.org/W2110945660","https://openalex.org/W2002311807","https://openalex.org/W3193238759","https://openalex.org/W90907977","https://openalex.org/W3164031938","https://openalex.org/W2048338194"],"abstract_inverted_index":{"It":[0],"has":[1,39],"long":[2],"been":[3],"established":[4],"that":[5],"thyroid":[6,30,85],"hormones":[7],"are":[8],"essential":[9],"for":[10,29],"correct":[11],"development":[12],"and":[13,68],"differentiation":[14],"in":[15,55,80,83],"the":[16,33,41,45,49,56,62,81,89],"central":[17],"nervous":[18],"system":[19],"(CNS).":[20],"More":[21],"recent":[22],"identification":[23],"of":[24,27,35,64,77,99,101,103],"a":[25],"family":[26,63],"receptors":[28,59,67,87],"hormone":[31,50,66,86],"as":[32,70],"products":[34],"cellular":[36,95],"erbA":[37],"genes":[38],"provided":[40],"opportunity":[42],"to":[43,61],"understand":[44],"mechanisms":[46],"by":[47,97],"which":[48,84],"elicits":[51],"its":[52],"complex":[53],"responses":[54,96],"CNS.":[57],"These":[58],"belong":[60],"nuclear":[65],"act":[69],"ligand-responsive":[71],"transcription":[72,100],"factors.":[73],"This":[74],"suggests":[75],"models":[76],"developmental":[78],"control":[79],"CNS":[82],"convert":[88],"extracellular":[90],"hormonal":[91],"signal":[92],"into":[93],"specific":[94],"regulation":[98],"networks":[102],"target":[104],"genes.":[105]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}