{"id":"https://openalex.org/W2405915917","doi":"https://doi.org/10.1042/bj1440455","title":"Effect of cobalt on the synthesis and degradation of hepatic catalse in vivo","display_name":"Effect of cobalt on the synthesis and degradation of hepatic catalse in vivo","publication_year":1974,"publication_date":"1974-12-01","ids":{"openalex":"https://openalex.org/W2405915917","doi":"https://doi.org/10.1042/bj1440455","mag":"2405915917","pmid":"https://pubmed.ncbi.nlm.nih.gov/4468818","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1168523"},"language":"en","primary_location":{"id":"doi:10.1042/bj1440455","doi":"https://doi.org/10.1042/bj1440455","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1440455","pdf_url":"https://portlandpress.com/biochemj/article-pdf/144/3/455/563583/bj1440455.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/144/3/455/563583/bj1440455.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113997908","display_name":"Y. Yasukochi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y Yasukochi","raw_affiliation_strings":["Department of Biochemistry, Kyushu University School of Medicine, Fukuoka 812, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Kyushu University School of Medicine, Fukuoka 812, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111164144","display_name":"M. Nakamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Nakamura","raw_affiliation_strings":["Department of Biochemistry, Kyushu University School of Medicine, Fukuoka 812, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Kyushu University School of Medicine, Fukuoka 812, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110182066","display_name":"S Minakami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Minakami","raw_affiliation_strings":["Department of Biochemistry, Kyushu University School of Medicine, Fukuoka 812, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Kyushu University School of Medicine, Fukuoka 812, Japan","institution_ids":["https://openalex.org/I135598925"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I135598925"],"apc_list":null,"apc_paid":null,"fwci":1.8967,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.85802628,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"144","issue":"3","first_page":"455","last_page":"464"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.4032999873161316,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.4032999873161316,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.37450000643730164,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.06520000100135803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cobalt-chloride","display_name":"cobalt chloride","score":0.8349999785423279},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.8019999861717224},{"id":"https://openalex.org/keywords/haem-synthesis","display_name":"haem synthesis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/5-aminolevulinic-acid","display_name":"5-aminolevulinic acid","score":0.7900000214576721},{"id":"https://openalex.org/keywords/leucine-incorporation","display_name":"leucine incorporation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/mitochondrial-catalase","display_name":"mitochondrial catalase","score":0.8730000257492065},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.5870000123977661},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7818354368209839},{"id":"https://openalex.org/C515602321","wikidata":"https://www.wikidata.org/wiki/Q740","display_name":"Cobalt","level":2,"score":0.7708250284194946},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.6320772171020508},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5406837463378906},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3944929838180542},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.264944851398468},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14814069867134094},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.12777692079544067},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.12570732831954956},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000622","descriptor_name":"Aminolevulinic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003035","descriptor_name":"Cobalt","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003035","descriptor_name":"Cobalt","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj1440455","doi":"https://doi.org/10.1042/bj1440455","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1440455","pdf_url":"https://portlandpress.com/biochemj/article-pdf/144/3/455/563583/bj1440455.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1168523","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1168523","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:4468818","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4468818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/bj1440455","doi":"https://doi.org/10.1042/bj1440455","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1440455","pdf_url":"https://portlandpress.com/biochemj/article-pdf/144/3/455/563583/bj1440455.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2405915917.pdf","grobid_xml":"https://content.openalex.org/works/W2405915917.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W66863327","https://openalex.org/W81000944","https://openalex.org/W589288770","https://openalex.org/W1482280407","https://openalex.org/W1551840741","https://openalex.org/W1558857728","https://openalex.org/W1768247331","https://openalex.org/W1775749144","https://openalex.org/W1964479613","https://openalex.org/W1987569922","https://openalex.org/W1992052761","https://openalex.org/W1995102926","https://openalex.org/W2028154108","https://openalex.org/W2035724742","https://openalex.org/W2070084596","https://openalex.org/W2095558922","https://openalex.org/W2112038605","https://openalex.org/W2137502740","https://openalex.org/W2324109957","https://openalex.org/W2473809511"],"related_works":["https://openalex.org/W1920267726","https://openalex.org/W4233224311","https://openalex.org/W1720237159","https://openalex.org/W1870722749","https://openalex.org/W2411014515","https://openalex.org/W1668992842","https://openalex.org/W1819675913","https://openalex.org/W1512594715","https://openalex.org/W1626733937","https://openalex.org/W142483904"],"abstract_inverted_index":{"1.":[0],"The":[1,30,116,160],"administration":[2],"of":[3,22,57,61,73,85,101,119,141,163],"CoCl(2)":[4],"to":[5],"rats":[6,92],"caused":[7],"a":[8,17,54,70,94,98,108,169],"decrease":[9,18],"in":[10,19,91,93,105,112,134],"hepatic":[11],"catalase":[12,23,64,78,126,147,157,164],"activity":[13],"as":[14,16,25,166],"well":[15],"the":[20,39,135,139,176],"amount":[21],"protein":[24,79,89],"measured":[26,167],"by":[27,69,168,175],"immunological":[28],"assay.":[29],"mitochondrial":[31,123,144],"enzyme":[32,41],"decreased":[33,42,68],"progressively":[34],"over":[35,43],"2":[36,51],"days,":[37],"whereas":[38,138],"cytosol":[40,125,146],"12h":[44],"and":[45,124,145],"then":[46],"remained":[47,80],"essentially":[48,81],"unchanged":[49],"for":[50],"days":[52],"after":[53],"single":[55,71],"injection":[56,72,100],"cobalt.":[58],"2.":[59],"Incorporation":[60,84],"[(14)C]glycine":[62],"into":[63,77,87,122,143],"haem":[65,153],"was":[66,104,131,148,155,172],"dramatically":[67],"cobalt,":[74,102],"but":[75],"that":[76,152],"unaltered.":[82],"3.":[83],"[(3)H]leucine":[86,120],"liver":[88],"increased":[90],"steady":[95],"state":[96],"receiving":[97],"daily":[99],"which":[103],"contrast":[106],"with":[107],"marked":[109],"inhibition":[110],"observed":[111],"5-amino[(3)H]laevulinate":[113,142],"incorporation.":[114],"4.":[115],"initial":[117],"rate":[118,162],"incorporation":[121,140],"did":[127],"not":[128,173],"alter":[129],"or":[130],"slightly":[132],"depressed":[133],"cobalt-treated":[136],"animals,":[137],"conspicuously":[149],"decreased,":[150],"indicating":[151],"synthesis":[154],"limiting":[156],"formation.":[158],"5.":[159],"degradation":[161],"protein,":[165],"double-labelling":[170],"method,":[171],"changed":[174],"cobalt":[177],"treatment.":[178]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}