{"id":"https://openalex.org/W2405720985","doi":null,"title":"An intact PDGF signaling pathway is required for efficient growth transformation of mouse C127 cells by the bovine papillomavirus E5 protein.","display_name":"An intact PDGF signaling pathway is required for efficient growth transformation of mouse C127 cells by the bovine papillomavirus E5 protein.","publication_year":1995,"publication_date":"1995-04-06","ids":{"openalex":"https://openalex.org/W2405720985","mag":"2405720985","pmid":"https://pubmed.ncbi.nlm.nih.gov/7731695"},"language":"en","primary_location":{"id":"pmid:7731695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7731695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047347828","display_name":"David J. Riese","orcid":"https://orcid.org/0000-0002-8823-5802","observed_orcids":["https://orcid.org/0000-0002-8823-5802"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D J Riese","raw_affiliation_strings":["Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028430067","display_name":"Daniel DiMaio","orcid":"https://orcid.org/0000-0002-2060-5977","observed_orcids":["https://orcid.org/0000-0002-2060-5977"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D DiMaio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4145,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.88740203,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"10","issue":"7","first_page":"1431","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.5684000253677368,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.5684000253677368,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.061900001019239426,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.051100000739097595,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bovine-papillomavirus-type-1","display_name":"bovine papillomavirus type 1","score":0.8980000019073486},{"id":"https://openalex.org/keywords/e5-protein","display_name":"E5 protein","score":0.8759999871253967},{"id":"https://openalex.org/keywords/pdgf-receptor-beta","display_name":"PDGF receptor beta","score":0.9269999861717224},{"id":"https://openalex.org/keywords/growth-transformation","display_name":"growth transformation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.6990000009536743},{"id":"https://openalex.org/keywords/oncogenic-transformation","display_name":"oncogenic transformation","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.8273897767066956},{"id":"https://openalex.org/C2776781592","wikidata":"https://www.wikidata.org/wiki/Q4950565","display_name":"Bovine papillomavirus","level":4,"score":0.802047848701477},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7822816371917725},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5519345998764038},{"id":"https://openalex.org/C2781294074","wikidata":"https://www.wikidata.org/wiki/Q22327352","display_name":"Platelet-derived growth factor","level":5,"score":0.5424251556396484},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.46575289964675903},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.46417853236198425},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4526394307613373},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4468207061290741},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.416224867105484},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3936101198196411},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1982342004776001},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15776285529136658},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009856","descriptor_name":"Oncogene Proteins, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017479","descriptor_name":"Receptors, Platelet-Derived Growth Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052688","descriptor_name":"Bovine papillomavirus 1","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7731695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7731695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"mag:2405720985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7731695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8624074680","display_name":"Molecular Basis of Cancer Virus Replication, Transformation, and Innate Defense","funder_award_id":"P01CA016038","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1796832639","https://openalex.org/W1251519535","https://openalex.org/W2097716740","https://openalex.org/W2127601115","https://openalex.org/W1874875782","https://openalex.org/W2127993829","https://openalex.org/W1919926060","https://openalex.org/W1556778240","https://openalex.org/W7097019940","https://openalex.org/W2085652591"],"abstract_inverted_index":{"The":[0,150],"bovine":[1,23],"papillomavirus":[2],"type":[3],"1":[4],"(BPV)":[5],"E5":[6,30,64,92,111,172,196,227],"protein":[7,14,31,112],"is":[8,215],"a":[9,106,133,155,175,180],"44":[10],"amino":[11],"acid,":[12],"membrane-associated":[13],"that":[15,123,140,208],"induces":[16],"growth":[17,36,85,191,219],"transformation":[18,61,86,192,220],"of":[19,44,87,161,169,183,221],"cultured":[20],"rodent":[21],"and":[22,41,174,197],"fibroblasts.":[24,116],"In":[25],"transformed":[26],"fibroblasts,":[27],"the":[28,33,42,45,63,68,90,99,109,146,159,166,170,194,206,209,225],"BPV":[29,91,110,171,195,226],"activates":[32],"endogenous":[34,69,100],"platelet-derived":[35],"factor":[37],"(PDGF)":[38],"beta":[39,47,57,71,102,185,211],"receptor,":[40],"introduction":[43],"PDGF":[46,56,70,101,131,147,184,210],"receptor":[48,58,72,103,186,212],"gene":[49],"into":[50],"heterologous":[51],"cell":[52,121,177],"types":[53],"normally":[54],"lacking":[55],"expression":[59,168],"permits":[60],"by":[62,89,165,193,224],"protein.":[65],"However,":[66],"neither":[67],"nor":[73],"its":[74],"signaling":[75,148,213],"pathway":[76,214],"has":[77],"been":[78],"shown":[79],"to":[80,130,136],"be":[81],"required":[82,216],"for":[83,108,205,217],"efficient":[84,218],"fibroblasts":[88],"gene.":[93,228],"Here":[94],"we":[95],"have":[96],"tested":[97],"whether":[98],"serves":[104],"as":[105],"target":[107],"in":[113,128,145,158],"mouse":[114],"C127":[115,120,222],"We":[117],"isolated":[118],"variant":[119,151,176],"lines":[122,152],"displayed":[124,188],"reduced":[125,181,189],"DNA":[126,162],"synthesis":[127,163],"response":[129,135],"but":[132],"normal":[134],"other":[137],"mitogens,":[138],"suggesting":[139],"they":[141],"harbor":[142],"specific":[143,156],"defects":[144],"pathway.":[149],"also":[153,187],"exhibited":[154],"reduction":[157],"level":[160,182],"induced":[164],"acute":[167],"gene,":[173],"line":[178],"containing":[179],"stable":[190],"v-sis":[198],"oncogenes.":[199],"These":[200],"results":[201],"provide":[202],"genetic":[203],"support":[204],"model":[207],"cells":[223]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
