{"id":"https://openalex.org/W2405237752","doi":null,"title":"Circulating endothelin-1 levels in systemic sclerosis subsets--a marker of fibrosis or vascular dysfunction?","display_name":"Circulating endothelin-1 levels in systemic sclerosis subsets--a marker of fibrosis or vascular dysfunction?","publication_year":1994,"publication_date":"1994-10-01","ids":{"openalex":"https://openalex.org/W2405237752","mag":"2405237752","pmid":"https://pubmed.ncbi.nlm.nih.gov/7837147"},"language":"en","primary_location":{"id":"pmid:7837147","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7837147","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091493743","display_name":"Rama Vancheeswaran","orcid":"https://orcid.org/0000-0002-9721-6734","observed_orcids":["https://orcid.org/0000-0002-9721-6734"]},"institutions":[{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R Vancheeswaran","raw_affiliation_strings":["Department of Rheumatology, Royal Free Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Royal Free Hospital, London, UK","institution_ids":["https://openalex.org/I2801138448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045846736","display_name":"T. Magoulas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Magoulas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017565436","display_name":"G Efrat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Efrat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016784740","display_name":"Caroline P.D. Wheeler-Jones","orcid":"https://orcid.org/0000-0002-6542-7713","observed_orcids":["https://orcid.org/0000-0002-6542-7713"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Wheeler-Jones","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108524291","display_name":"Irwin Olsen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Olsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"R Penny","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Penny","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113513578","display_name":"Carol M. Black","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C M Black","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.853,"has_fulltext":false,"cited_by_count":238,"citation_normalized_percentile":{"value":0.96031061,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"21","issue":"10","first_page":"1838","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.9919999837875366},{"id":"https://openalex.org/keywords/raynaud-s-phenomenon","display_name":"Raynaud's phenomenon","score":0.8140000104904175},{"id":"https://openalex.org/keywords/diffuse-cutaneous-systemic-sclerosis","display_name":"diffuse cutaneous systemic sclerosis","score":0.8429999947547913},{"id":"https://openalex.org/keywords/limited-cutaneous-systemic-sclerosis","display_name":"limited cutaneous systemic sclerosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/skin-fibrosis","display_name":"skin fibrosis","score":0.8069999814033508},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.8769999742507935},{"id":"https://openalex.org/keywords/angiotensin-converting-enzyme","display_name":"angiotensin-converting enzyme","score":0.9819999933242798},{"id":"https://openalex.org/keywords/endothelial-injury","display_name":"endothelial injury","score":0.6729999780654907},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.5820000171661377},{"id":"https://openalex.org/keywords/vascular-dysfunction","display_name":"vascular dysfunction","score":0.5529999732971191},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9007304906845093},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.657583475112915},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.5559223890304565},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5416304469108582},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.541034460067749},{"id":"https://openalex.org/C2779967694","wikidata":"https://www.wikidata.org/wiki/Q1383511","display_name":"Scleroderma (fungus)","level":3,"score":0.5407135486602783},{"id":"https://openalex.org/C149601957","wikidata":"https://www.wikidata.org/wiki/Q390566","display_name":"Endothelin 1","level":3,"score":0.4975912868976593},{"id":"https://openalex.org/C2779625490","wikidata":"https://www.wikidata.org/wiki/Q5340515","display_name":"Systemic scleroderma","level":3,"score":0.4813902676105499},{"id":"https://openalex.org/C2777543607","wikidata":"https://www.wikidata.org/wiki/Q1153419","display_name":"Interstitial lung disease","level":3,"score":0.47250258922576904},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.47163841128349304},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.4707123637199402},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.46692678332328796},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4622924029827118},{"id":"https://openalex.org/C2778674544","wikidata":"https://www.wikidata.org/wiki/Q1414805","display_name":"Systemic disease","level":3,"score":0.458556592464447},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.45064857602119446},{"id":"https://openalex.org/C2776670291","wikidata":"https://www.wikidata.org/wiki/Q1779300","display_name":"Connective tissue disease","level":4,"score":0.43728533387184143},{"id":"https://openalex.org/C2908744134","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Lung fibrosis","level":4,"score":0.43404048681259155},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4199559688568115},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3707852363586426},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.2888143062591553},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.06157335638999939},{"id":"https://openalex.org/C180032290","wikidata":"https://www.wikidata.org/wiki/Q1664296","display_name":"Inoculation","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006977","descriptor_name":"Hypertension, Renal","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006977","descriptor_name":"Hypertension, Renal","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006977","descriptor_name":"Hypertension, Renal","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007703","descriptor_name":"Peptidyl-Dipeptidase A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016232","descriptor_name":"Endothelins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016232","descriptor_name":"Endothelins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7837147","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7837147","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Clinical Trial"},{"id":"mag:2405237752","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7837147","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2059156256","https://openalex.org/W3088384645","https://openalex.org/W1985803879","https://openalex.org/W29780280","https://openalex.org/W2390373584","https://openalex.org/W2369443416","https://openalex.org/W2413437988","https://openalex.org/W2091944102","https://openalex.org/W7163679372","https://openalex.org/W3164097002"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,32,44,57,70,80,102,167,174,254,274,278],"circulating":[4,81],"levels":[5,48,82,135,169,195,210,238,259],"of":[6,36,46,61,72,83,98,108,178,196,225,234,262,276],"endothelin-1":[7],"(ET-1)":[8],"in":[9,12,31,40,49,74,101,113,139,163,171,227,239,273,283],"serum":[10,75],"(sET-1)":[11],"patients":[13,115,123,153,172,183,201,228,240,247],"with":[14,116,124,130,144,152,154,173,184,186,202,216,229,241,243,248,250],"pulmonary":[15,21],"disease":[16,104,142,191,226,252],"[pulmonary":[17],"fibrosis":[18,220,245,263],"(PF)":[19],"and":[20,24,64,88,121,206,223,246,253,260,264,280],"hypertension":[22],"(PHT)],":[23],"renal":[25,28,190],"involvement":[26,54],"[hypertensive":[27],"crisis":[29],"(HRC)]":[30],"2":[33],"major":[34],"subsets":[35],"systemic":[37,118],"sclerosis":[38,119],"(SSc)":[39],"order":[41],"to":[42,51,56,69,166,214],"determine":[43],"significance":[45],"sET-1":[47,109,134,168,197,209,237,258],"relation":[50],"specific":[52],"organ":[53],"or":[55,148,157,189],"underlying":[58],"pathogenic":[59],"mechanisms":[60],"vascular":[62,265,281],"damage":[63,100,266],"fibrosis.":[65],"METHODS:":[66],"In":[67],"addition":[68],"measurement":[71],"ET-1":[73,269],"using":[76],"a":[77],"competitive":[78],"radioimmunoassay,":[79],"angiotensin":[84],"converting":[85],"enzyme":[86],"(ACE)":[87],"plasma":[89,217],"von":[90],"Willebrand":[91],"factor":[92],"(vWF)":[93],"were":[94,110,136,162,211],"measured":[95],"as":[96],"markers":[97,261],"endothelial":[99],"various":[103],"groups.":[105],"RESULTS:":[106],"Levels":[107],"significantly":[111,193,235],"increased":[112],"64":[114],"diffuse":[117,140],"(dSSc)":[120],"17":[122],"primary":[125],"Raynaud's":[126],"phenomenon":[127],"(RP)":[128],"compared":[129,151],"22":[131],"healthy":[132],"individuals.":[133],"equally":[137],"elevated":[138],"cutaneous":[141,176],"(dcSSc)":[143],"only":[145,182,203],"fibrotic":[146,204,279],"dermal":[147,205],"lung":[149,188,207],"pathology":[150],"additional":[155],"PHT":[156],"HRC":[158],"crisis.":[159],"These":[160],"observations":[161],"marked":[164],"contrast":[165],"seen":[170,256],"limited":[175],"form":[177],"SSc":[179],"(lcSSc)":[180],"where":[181],"lcSSc":[185,200,249],"hypertensive":[187,251],"had":[192],"higher":[194],"than":[198],"comparable":[199],"disease.":[208],"additionally":[212],"found":[213],"correlate":[215],"vWF,":[218],"skin":[219],"(skin":[221],"score)":[222],"duration":[224],"SSc.":[230,284],"CONCLUSION:":[231],"The":[232],"presence":[233],"raised":[236],"dcSSc":[242],"widespread":[244],"relationship":[255],"between":[257],"suggest":[267],"that":[268],"may":[270],"be":[271],"important":[272],"pathogenesis":[275],"both":[277],"manifestations":[282]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
