{"id":"https://openalex.org/W2405199880","doi":null,"title":"Levels of chemokine receptors expressed on peripheral blood T lymphocytes of Egyptian patients with hepatocellular carcinoma.","display_name":"Levels of chemokine receptors expressed on peripheral blood T lymphocytes of Egyptian patients with hepatocellular carcinoma.","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2405199880","mag":"2405199880","pmid":"https://pubmed.ncbi.nlm.nih.gov/20726319"},"language":"en","primary_location":{"id":"pmid:20726319","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20726319","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Egyptian journal of immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112407326","display_name":"Maha Allam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405261924","display_name":"National Liver Institute","ror":"https://ror.org/00avfvp71","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4405261924","https://openalex.org/I63601056"]},{"id":"https://openalex.org/I63601056","display_name":"Menoufia University","ror":"https://ror.org/05sjrb944","country_code":"EG","type":"education","lineage":["https://openalex.org/I63601056"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Maha M Allam","raw_affiliation_strings":["Department of Clinical Pathology, National Liver Institute-Menoufiya University, Menoufiya, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathology, National Liver Institute-Menoufiya University, Menoufiya, Egypt","institution_ids":["https://openalex.org/I4405261924","https://openalex.org/I63601056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087856533","display_name":"Abd El Moneim E","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elhamy Abd El Moneim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043438275","display_name":"Mona Mahmoud Hassouna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mouna M Hassouna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005113966","display_name":"El Jaky A","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashraf El Jaky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020219645","display_name":"H Zaghlah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hassan Zaghlah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.39302498,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"16","issue":"1","first_page":"17","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9160000085830688},{"id":"https://openalex.org/keywords/chemokine-receptors","display_name":"chemokine receptors","score":0.8759999871253967},{"id":"https://openalex.org/keywords/ccr1","display_name":"CCR1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ccr5","display_name":"CCR5","score":1.0},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":1.0},{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.8859999775886536},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.7549999952316284},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.8539999723434448},{"id":"https://openalex.org/keywords/peripheral-blood","display_name":"peripheral blood","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.7648837566375732},{"id":"https://openalex.org/C129013479","wikidata":"https://www.wikidata.org/wiki/Q21111916","display_name":"CCR1","level":5,"score":0.7339074611663818},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.616544246673584},{"id":"https://openalex.org/C128879288","wikidata":"https://www.wikidata.org/wiki/Q5009764","display_name":"CC chemokine receptors","level":5,"score":0.6056922078132629},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.589980959892273},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5828555822372437},{"id":"https://openalex.org/C29146819","wikidata":"https://www.wikidata.org/wiki/Q21113975","display_name":"CCL13","level":5,"score":0.46348315477371216},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4410621225833893},{"id":"https://openalex.org/C45635710","wikidata":"https://www.wikidata.org/wiki/Q418404","display_name":"Chemokine receptor CCR5","level":5,"score":0.43793758749961853},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4220609664916992},{"id":"https://openalex.org/C206615009","wikidata":"https://www.wikidata.org/wiki/Q4035572","display_name":"CCR2","level":5,"score":0.41884246468544006},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4172824025154114},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3763524889945984},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.14821037650108337}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004534","descriptor_name":"Egypt","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D019713","descriptor_name":"Receptors, CCR5","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D054389","descriptor_name":"Receptors, CCR1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:20726319","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20726319","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Egyptian journal of immunology","raw_type":"Journal Article"},{"id":"mag:2405199880","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20726319","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1523694553","https://openalex.org/W1793524329","https://openalex.org/W1985771879","https://openalex.org/W1992492585","https://openalex.org/W1997882893","https://openalex.org/W1999949446","https://openalex.org/W2007739409","https://openalex.org/W2012353447","https://openalex.org/W2015825148","https://openalex.org/W2042521994","https://openalex.org/W2054013276","https://openalex.org/W2057177746","https://openalex.org/W2101832306","https://openalex.org/W2107456313","https://openalex.org/W2115920402","https://openalex.org/W2123563900","https://openalex.org/W2130423714","https://openalex.org/W2156323704","https://openalex.org/W2157329817","https://openalex.org/W2164198318","https://openalex.org/W2417773008"],"related_works":["https://openalex.org/W1999949446","https://openalex.org/W2045846716","https://openalex.org/W2085319564","https://openalex.org/W1987144092","https://openalex.org/W2259898792","https://openalex.org/W7098931616","https://openalex.org/W2745865040","https://openalex.org/W2977455418","https://openalex.org/W2016688357","https://openalex.org/W3112605892"],"abstract_inverted_index":{"CC":[0],"chemokine":[1,36,64,175,188],"receptors":[2,65,176,189],"(CCR)":[3],"have":[4],"an":[5,80],"important":[6],"role":[7,290],"in":[8,45,79,86,125,202,218,231,250,261,291],"the":[9,14,60,70,126,136,219,293],"recruitment":[10],"of":[11,16,22,63,72,95,98,174,187,221,254,277],"leukocytes":[12],"to":[13,82,135,211,235,307],"site":[15],"inflammation.":[17],"The":[18,88,185],"migration":[19],"and":[20,40,50,67,103,120,130,145,166,171,178,191,195,204,223,256,279,283,297],"metastasis":[21],"tumor":[23,265],"cells":[24,49],"shares":[25],"many":[26],"similarities":[27],"with":[28,52,77,100,105,117,237,263],"leukocyte":[29],"trafficking,":[30],"which":[31],"is":[32],"mainly":[33],"regulated":[34],"by":[35],"receptor-ligand":[37],"interactions.":[38],"CCR1":[39,66,177,190,222,255,278],"CCR5":[41,68,179,192,224,257,280],"are":[42],"highly":[43],"expressed":[44],"hepatocellular":[46],"carcinoma":[47],"(HCC)":[48],"tissues":[51],"unknown":[53],"functions.":[54],"In":[55,111],"this":[56],"study,":[57],"we":[58],"estimated":[59],"surface":[61,275],"expression":[62,186,276],"on":[69,92,180,193,225,281],"lymphocytes":[71,198,228,286],"peripheral":[73,181],"blood":[74,156,182],"from":[75],"patients":[76,94,233,236,262],"HCC":[78,102,203,232,251],"attempt":[81],"identify":[83],"their":[84,288],"roles":[85],"tumorigenesis.":[87],"study":[89],"was":[90,199,229,242],"conducted":[91],"52":[93],"which,":[96],"24":[97],"them":[99],"confirmed":[101],"28":[104],"chronic":[106,238],"hepatitis":[107,164,205],"C":[108,206],"virus":[109],"infection.":[110],"addition,":[112],"20":[113],"apparently":[114],"healthy":[115],"controls":[116],"matched":[118],"age":[119],"sex":[121],"were":[122,133,258],"also":[123],"included":[124],"study.":[127],"All":[128],"patient":[129,207],"control":[131,212],"groups":[132,208],"subjected":[134],"following:":[137],"thorough":[138],"history":[139],"taking,":[140],"clinical":[141],"examination,":[142],"abdominal":[143],"ultrasonography":[144],"fine":[146],"needle":[147],"liver":[148,158],"biopsy":[149],"for":[150,163,246,304],"patient's":[151],"group":[152],"when":[153],"needed,":[154],"complete":[155],"count,":[157],"function":[159],"tests,":[160],"viral":[161],"markers":[162],"B":[165],"C,":[167],"serum":[168],"alpha":[169],"fetoprotein":[170],"flowcytometric":[172],"detection":[173],"T":[183,197,227,285],"lymphocytes.":[184],"CD4+":[194,247],"CD8+":[196,226],"significantly":[200,259],"less":[201,260],"as":[209],"compared":[210,234],"group.":[213],"Moreover,":[214],"a":[215],"significant":[216,245],"decrease":[217],"levels":[220,253],"detected":[230],"HCV;":[239],"however,":[240],"it":[241],"not":[243],"statistically":[244],"cells.":[248],"Furthermore":[249],"patients,":[252],"large":[264],"size":[266],"than":[267],"small":[268],"sized":[269],"tumor.":[270],"Data":[271],"obtained":[272],"showing":[273],"reduced":[274],"CD4":[282],"CD8":[284],"reflect":[287],"possible":[289],"altering":[292],"host's":[294],"immune":[295],"defense":[296],"disease":[298,309],"pathogenesis,":[299],"thus":[300],"may":[301],"be":[302],"helpful":[303],"therapy":[305],"design":[306],"ameliorate":[308],"progression.":[310]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
