{"id":"https://openalex.org/W2405046988","doi":null,"title":"Herbal complex suppresses telomerase activity in chemo-endocrine resistant cancer cell lines.","display_name":"Herbal complex suppresses telomerase activity in chemo-endocrine resistant cancer cell lines.","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2405046988","mag":"2405046988","pmid":"https://pubmed.ncbi.nlm.nih.gov/11766737"},"language":"en","primary_location":{"id":"pmid:11766737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11766737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of gynaecological oncology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000910571","display_name":"Zengling Lian","orcid":"https://orcid.org/0000-0003-1087-6981","observed_orcids":["https://orcid.org/0000-0003-1087-6981"]},"institutions":[{"id":"https://openalex.org/I4210105815","display_name":"Gifu University Hospital","ror":"https://ror.org/01kqdxr19","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210105815"]},{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Z Lian","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City, Japan","Department of Obstetrics & Gynecology, Gifu University School of Medicine, Gifu-city, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City, Japan","institution_ids":["https://openalex.org/I4210105815","https://openalex.org/I42405503"]},{"raw_affiliation_string":"Department of Obstetrics & Gynecology, Gifu University School of Medicine, Gifu-city, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082372978","display_name":"Junya Fujimoto","orcid":"https://orcid.org/0000-0003-4813-3163","observed_orcids":["https://orcid.org/0000-0003-4813-3163"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Fujimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Y Yokoyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Yokoyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001618823","display_name":"Koichiro Niwa","orcid":"https://orcid.org/0000-0002-3895-0525","observed_orcids":["https://orcid.org/0000-0002-3895-0525"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Niwa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111410884","display_name":"T Tamaya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Tamaya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3779,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.49475524,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"5","first_page":"347","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomerase-activity","display_name":"telomerase activity","score":0.9210000038146973},{"id":"https://openalex.org/keywords/htert","display_name":"hTERT","score":0.6880000233650208},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7450000047683716},{"id":"https://openalex.org/keywords/endocrine-resistance","display_name":"endocrine therapy resistance","score":0.8889999985694885},{"id":"https://openalex.org/keywords/scutellariae-radix","display_name":"Scutellariae Radix","score":1.0},{"id":"https://openalex.org/keywords/radix-glycyrrhizae","display_name":"Radix Glycyrrhizae","score":1.0},{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.9610000252723694},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8790000081062317},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.8916835188865662},{"id":"https://openalex.org/C125593758","wikidata":"https://www.wikidata.org/wiki/Q15315135","display_name":"Telomerase reverse transcriptase","level":4,"score":0.7752467393875122},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6340039968490601},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5911360383033752},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5428853034973145},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5426178574562073},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31499162316322327},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24128559231758118},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06837290525436401},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11766737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11766737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of gynaecological oncology","raw_type":"Journal Article"},{"id":"mag:2405046988","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11766737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1990072718","https://openalex.org/W2362605926","https://openalex.org/W2063661577","https://openalex.org/W2350818976","https://openalex.org/W7144090159","https://openalex.org/W2032032972","https://openalex.org/W1975284843","https://openalex.org/W4225116393","https://openalex.org/W2139887884","https://openalex.org/W2083043210"],"abstract_inverted_index":{"A":[0],"herbal":[1,51,76],"complex":[2,52,77],"consisting":[3],"of":[4,56,60,83,93],"Hoelen,":[5],"Angelicae":[6],"radix,":[7],"Scutellariae":[8],"radix":[9,12],"and":[10,16,21,42],"Glycyrrhizae":[11],"suppressed":[13,53],"cell":[14,24,32,39,46],"viability":[15],"telomerase":[17,62,70,94],"activity":[18,95],"in":[19,89],"hormone-refractory":[20],"chemo-resistant":[22],"cancer":[23,31,38,45],"lines,":[25],"namely":[26],"poorly":[27],"differentiated":[28],"uterine":[29],"endometrial":[30],"line":[33,40,47],"AN3":[34],"CA,":[35],"adriamycin-resistant":[36],"breast":[37],"MCF7/ADR":[41],"cisplatin-resistant":[43],"ovarian":[44],"A2780.":[48],"Furthermore,":[49],"the":[50,54,57,75,80],"expression":[55],"full":[58],"length":[59],"human":[61],"reverse":[63],"transcriptase":[64],"(hTERT),":[65],"which":[66],"is":[67],"related":[68],"to":[69],"activity.":[71],"This":[72],"indicates":[73],"that":[74],"can":[78],"suppress":[79],"tumor":[81],"growth":[82],"chemoendocrine":[84],"resistant":[85],"cancers,":[86],"at":[87],"least":[88],"part":[90],"via":[91],"suppression":[92],"associated":[96],"with":[97],"down-regulated":[98],"hTERT.":[99]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}