{"id":"https://openalex.org/W2405042298","doi":null,"title":"Effects of cadmium on the energy metabolism of isolated hepatocytes: its relationship with the nonviability of isolated hepatocytes caused by cadmium.","display_name":"Effects of cadmium on the energy metabolism of isolated hepatocytes: its relationship with the nonviability of isolated hepatocytes caused by cadmium.","publication_year":1990,"publication_date":"1990-09-01","ids":{"openalex":"https://openalex.org/W2405042298","mag":"2405042298","pmid":"https://pubmed.ncbi.nlm.nih.gov/2252545"},"language":"en","primary_location":{"id":"pmid:2252545","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2252545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical and environmental sciences : BES","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004873758","display_name":"R M Liu","orcid":"https://orcid.org/0000-0002-4197-3971","observed_orcids":["https://orcid.org/0000-0002-4197-3971"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R M Liu","raw_affiliation_strings":["Department of Environmental Toxicology, Tongji Medical University, Wuhan, Hubei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Toxicology, Tongji Medical University, Wuhan, Hubei Province, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049149326","display_name":"Y G Liun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y G Liun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.30160158,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"3","issue":"3","first_page":"251","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.6650000214576721,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.6650000214576721,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.32589998841285706,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cadmium","display_name":"cadmium","score":0.9179999828338623},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.8679999709129333},{"id":"https://openalex.org/keywords/mitochondrial-bioenergetics","display_name":"mitochondrial bioenergetics","score":0.8399999737739563},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.7710000276565552},{"id":"https://openalex.org/keywords/atp-content","display_name":"ATP levels","score":0.7590000033378601},{"id":"https://openalex.org/keywords/electron-transport-chain","display_name":"electron transport chain","score":0.699999988079071},{"id":"https://openalex.org/keywords/cytochrome-b","display_name":"cytochrome b","score":0.9419999718666077},{"id":"https://openalex.org/keywords/flavoprotein","display_name":"flavoprotein","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mitochondrial-uncoupling","display_name":"mitochondrial uncoupling","score":0.953000009059906},{"id":"https://openalex.org/keywords/mitochondrial-membrane-permeability","display_name":"mitochondrial membrane permeability","score":0.8659999966621399},{"id":"https://openalex.org/keywords/mitochondrial-membrane-fluidity","display_name":"mitochondrial membrane fluidity","score":0.6570000052452087},{"id":"https://openalex.org/keywords/heavy-metal-toxicity","display_name":"heavy metal toxicity","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C544657597","wikidata":"https://www.wikidata.org/wiki/Q1091","display_name":"Cadmium","level":2,"score":0.8786710500717163},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7996460199356079},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.6482484936714172},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5461217164993286},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5424119234085083},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.516314685344696},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4922889769077301},{"id":"https://openalex.org/C24840226","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Electron transport chain","level":2,"score":0.49039196968078613},{"id":"https://openalex.org/C3020377403","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Respiratory chain","level":3,"score":0.4825800955295563},{"id":"https://openalex.org/C182215343","wikidata":"https://www.wikidata.org/wiki/Q472287","display_name":"Respiration","level":2,"score":0.46766769886016846},{"id":"https://openalex.org/C66517615","wikidata":"https://www.wikidata.org/wiki/Q912751","display_name":"Cellular respiration","level":3,"score":0.45306405425071716},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.4268726110458374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3340665102005005},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.052459269762039185},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.05119353532791138},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.042567282915115356},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002104","descriptor_name":"Cadmium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003580","descriptor_name":"Cytochromes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005969","descriptor_name":"Glutamate Dehydrogenase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008560","descriptor_name":"Membrane Fluidity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013385","descriptor_name":"Succinate Dehydrogenase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:2252545","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2252545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical and environmental sciences : BES","raw_type":"Journal Article"},{"id":"mag:2405042298","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2252545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:3142136393","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/84046X/199003/4001628552.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306555121","display_name":"\u751f\u7269\u533b\u5b66\u4e0e\u73af\u5883\u79d1\u5b66\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u751f\u7269\u533b\u5b66\u4e0e\u73af\u5883\u79d1\u5b66\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2006008522","https://openalex.org/W2417765608","https://openalex.org/W2001502445","https://openalex.org/W6958342870","https://openalex.org/W2024432240","https://openalex.org/W1486069050","https://openalex.org/W2412584043","https://openalex.org/W2426146888","https://openalex.org/W2056436149","https://openalex.org/W1984535132"],"abstract_inverted_index":{"The":[0,60,80],"effects":[1,82],"of":[2,8,27,38,43,46,54,62,65,83,100],"cadmium":[3,23,72,89],"on":[4],"the":[5,25,35,52,66,96,101],"energy":[6,44],"metabolism":[7,45],"mitochondria":[9,32,47],"were":[10],"studied":[11],"with":[12],"isolated":[13,29,39,55],"hepatocytes":[14,30,56],"and":[15,31,33,78,98],"rat":[16],"liver":[17],"mitochondria.":[18],"It":[19],"was":[20,48,73],"found":[21],"that":[22],"inhibited":[24],"respiration":[26],"both":[28],"decreased":[34],"ATP":[36],"content":[37],"hepatocytes.":[40],"This":[41],"inhibition":[42],"highly":[49],"related":[50],"to":[51],"nonviability":[53],"caused":[57,87],"by":[58,71,88],"cadmium.":[59],"site":[61],"electron":[63],"transport":[64],"mitochondrial":[67,84,102],"respiratory":[68],"chain":[69],"blocked":[70],"located":[74],"between":[75],"cytochrome":[76],"b":[77],"flavo-proteins.":[79],"uncoupling":[81],"oxidative":[85],"phosphorylation":[86],"may":[90],"have":[91],"resulted":[92],"from":[93],"changes":[94],"in":[95],"fluidity":[97],"permeability":[99],"membrane.":[103]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
