{"id":"https://openalex.org/W2404922706","doi":null,"title":"Thyrotropin-secreting pituitary adenomas: biological and molecular features, diagnosis and therapy.","display_name":"Thyrotropin-secreting pituitary adenomas: biological and molecular features, diagnosis and therapy.","publication_year":2008,"publication_date":"2008-12-01","ids":{"openalex":"https://openalex.org/W2404922706","mag":"2404922706","pmid":"https://pubmed.ncbi.nlm.nih.gov/18923369"},"language":"en","primary_location":{"id":"pmid:18923369","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18923369","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva endocrinologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042420012","display_name":"Marco Losa","orcid":"https://orcid.org/0000-0001-7810-8247","observed_orcids":["https://orcid.org/0000-0001-7810-8247"]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]},{"id":"https://openalex.org/I4387155925","display_name":"IRCCS San Raffaele Roma","ror":"https://ror.org/006x48140","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387155925"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Losa","raw_affiliation_strings":["Pituitary Unit, Department of Neurosurgery, IRCCS San Raffaele, Vita-Salute University, Milan, Italy. losa.marco@hsr.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pituitary Unit, Department of Neurosurgery, IRCCS San Raffaele, Vita-Salute University, Milan, Italy. losa.marco@hsr.it","institution_ids":["https://openalex.org/I154387261","https://openalex.org/I4387155925"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Fortunato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Fortunato","raw_affiliation_strings":["Universita\u2019 Vita-Salute San Raffaele"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universita\u2019 Vita-Salute San Raffaele","institution_ids":["https://openalex.org/I154387261"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L Molteni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L Molteni","raw_affiliation_strings":["Universita\u2019 Vita-Salute San Raffaele"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universita\u2019 Vita-Salute San Raffaele","institution_ids":["https://openalex.org/I154387261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009690474","display_name":"Elena Peretti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E Peretti","raw_affiliation_strings":["Universita\u2019 Vita-Salute San Raffaele"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universita\u2019 Vita-Salute San Raffaele","institution_ids":["https://openalex.org/I154387261"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065788635","display_name":"Pietro Mortini","orcid":"https://orcid.org/0000-0003-2320-2281","observed_orcids":["https://orcid.org/0000-0003-2320-2281"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P Mortini","raw_affiliation_strings":["IRCCS Ospedale San Raffaele"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Ospedale San Raffaele","institution_ids":["https://openalex.org/I4210133214"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9771,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.79215178,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"33","issue":"4","first_page":"329","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyrotropinoma","display_name":"thyrotropinoma","score":0.9369999766349792},{"id":"https://openalex.org/keywords/tsh-secreting-pituitary-adenoma","display_name":"TSH-secreting pituitary adenoma","score":0.9779999852180481},{"id":"https://openalex.org/keywords/central-hyperthyroidism","display_name":"central hyperthyroidism","score":0.9900000095367432},{"id":"https://openalex.org/keywords/resistance-to-thyroid-hormone","display_name":"thyroid hormone resistance","score":0.6600000262260437},{"id":"https://openalex.org/keywords/somatostatin-analogs","display_name":"somatostatin analogues","score":0.8569999933242798},{"id":"https://openalex.org/keywords/dopamine-agonists","display_name":"dopamine agonists","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pituitary-surgery","display_name":"pituitary surgery","score":0.7689999938011169},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.7519999742507935},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.6159999966621399},{"id":"https://openalex.org/keywords/etiopathogenesis","display_name":"etiopathogenesis","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8888657093048096},{"id":"https://openalex.org/C2779318953","wikidata":"https://www.wikidata.org/wiki/Q864296","display_name":"Pituitary adenoma","level":3,"score":0.6314648985862732},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.6002801060676575},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5975856184959412},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5578476190567017},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5530532002449036},{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.5418428182601929},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5346535444259644},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.5200502276420593},{"id":"https://openalex.org/C2780801072","wikidata":"https://www.wikidata.org/wiki/Q837512","display_name":"Differential diagnosis","level":2,"score":0.45680397748947144},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.45529627799987793},{"id":"https://openalex.org/C2781449511","wikidata":"https://www.wikidata.org/wiki/Q864296","display_name":"Pituitary tumors","level":2,"score":0.4456930458545685},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27504491806030273}],"mesh":[{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010911","descriptor_name":"Pituitary Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010911","descriptor_name":"Pituitary Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D010911","descriptor_name":"Pituitary Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010911","descriptor_name":"Pituitary Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018491","descriptor_name":"Dopamine Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:18923369","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18923369","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva endocrinologica","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unisr.it:20.500.11768/18226","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11768/18226","pdf_url":null,"source":{"id":"https://openalex.org/S7407055348","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 Vita-Salute San Raffaele","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2404922706","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18923369","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2800749893","https://openalex.org/W2891175402","https://openalex.org/W91614082","https://openalex.org/W1514507967","https://openalex.org/W3201480760","https://openalex.org/W2054141989","https://openalex.org/W2954800995","https://openalex.org/W2119597210","https://openalex.org/W2480653996","https://openalex.org/W2417604483"],"abstract_inverted_index":{"Central":[0],"hyperthyroidism":[1,48,55],"due":[2],"to":[3,61,64,123,129],"a":[4,10],"thyrotropin":[5],"(TSH)-secreting":[6],"pituitary":[7,19,69,72,132],"adenoma":[8,40],"is":[9,25,127],"rare":[11,164],"cause":[12],"of":[13,17,23,47,56,67,93,102,104,121,135],"hyperthyroidism,":[14],"representing":[15],"0.5-1.0%":[16],"all":[18],"adenomas.":[20],"The":[21,79],"etiopathogenesis":[22],"TSH-secreting-adenomas":[24],"unknown":[26],"and":[27,45,77,109,145,155],"no":[28],"definite":[29],"role":[30],"for":[31],"various":[32],"oncogenes":[33],"has":[34],"been":[35],"proven.":[36],"Patients":[37],"with":[38,43,54,118,148,158],"TSH-secreting":[39,136],"usually":[41],"present":[42],"signs":[44],"symptoms":[46,62],"milder":[49],"than":[50],"those":[51],"in":[52,59,90,114,156],"patients":[53,167],"thyroid":[57,98,106,124],"origin,":[58],"addition":[60],"secondary":[63],"mass":[65],"effects":[66],"the":[68,91,115,119,131,159],"tumour.":[70],"Mixed":[71],"tumours":[73],"co-secrete":[74],"growth":[75],"hormone":[76,107],"prolactin.":[78],"characteristic":[80],"biochemical":[81],"abnormalities":[82],"are":[83,168],"normal":[84],"or":[85,151],"high":[86],"serum":[87],"TSH":[88],"concentrations":[89],"presence":[92],"elevated":[94],"total":[95],"and/or":[96],"free":[97],"hormones":[99],"concentrations.":[100],"Measurement":[101],"markers":[103],"peripheral":[105],"action":[108],"dynamic":[110],"tests":[111],"may":[112],"aid":[113],"differential":[116],"diagnosis":[117],"syndrome":[120],"resistance":[122],"hormone.":[125],"Neuroimaging":[126],"fundamental":[128],"visualize":[130],"tumor.":[133],"Therapy":[134],"adenomas":[137],"can":[138],"be":[139],"accomplished":[140],"by":[141,171],"surgery,":[142],"radiation":[143],"therapies,":[144],"medical":[146],"treatment":[147],"somatostatin":[149],"analogs":[150],"dopamine":[152],"agonists.":[153],"Nowadays,":[154],"contrast":[157],"first":[160],"reports":[161],"on":[162],"this":[163],"disease,":[165],"most":[166],"well":[169],"controlled":[170],"current":[172],"therapies.":[173]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
