{"id":"https://openalex.org/W2404900852","doi":"https://doi.org/10.1152/ajplegacy.1960.199.1.49","title":"Effect of strophanthidin on electrolyte excretion in the chicken","display_name":"Effect of strophanthidin on electrolyte excretion in the chicken","publication_year":1960,"publication_date":"1960-07-01","ids":{"openalex":"https://openalex.org/W2404900852","doi":"https://doi.org/10.1152/ajplegacy.1960.199.1.49","mag":"2404900852"},"language":"en","primary_location":{"id":"doi:10.1152/ajplegacy.1960.199.1.49","doi":"https://doi.org/10.1152/ajplegacy.1960.199.1.49","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplegacy.1960.199.1.49","pdf_url":null,"source":{"id":"https://openalex.org/S204210209","display_name":"American Journal of Physiology-Legacy Content","issn_l":"0002-9513","issn":["0002-9513","2163-5773"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Legacy Content","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089918858","display_name":"Jack Orloff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack Orloff","raw_affiliation_strings":["Laboratory of Kidney and Electrolyte Metabolism, National Heart Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Kidney and Electrolyte Metabolism, National Heart Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025916093","display_name":"Maurice B. Burg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maurice Burg","raw_affiliation_strings":["Laboratory of Kidney and Electrolyte Metabolism, National Heart Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Kidney and Electrolyte Metabolism, National Heart Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":null,"apc_paid":null,"fwci":5.8594,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.97134238,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"199","issue":"1","first_page":"49","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12876","display_name":"Potassium and Related Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/strophanthidin","display_name":"strophanthidin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cardiac-glycosides","display_name":"cardiac glycosides","score":0.8320000171661377},{"id":"https://openalex.org/keywords/renal-ion-transport","display_name":"renal ion transport","score":0.656000018119812},{"id":"https://openalex.org/keywords/sodium-excretion","display_name":"sodium excretion","score":0.9269999861717224},{"id":"https://openalex.org/keywords/urinary-potassium-excretion","display_name":"potassium excretion","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hydrogen-ion-secretion","display_name":"hydrogen ion secretion","score":0.7749999761581421},{"id":"https://openalex.org/keywords/urine-alkalinization","display_name":"urinary alkalinization","score":0.7670000195503235},{"id":"https://openalex.org/keywords/renal-tubules","display_name":"renal tubules","score":0.6620000004768372},{"id":"https://openalex.org/keywords/chickens","display_name":"chickens","score":0.5680000185966492},{"id":"https://openalex.org/keywords/carbonic-anhydrase-inhibitors","display_name":"carbonic anhydrase inhibitors","score":0.9079999923706055}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7820835709571838},{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.7217993140220642},{"id":"https://openalex.org/C2779396346","wikidata":"https://www.wikidata.org/wiki/Q394316","display_name":"Aglycone","level":3,"score":0.6753992438316345},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.5974056124687195},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5843575596809387},{"id":"https://openalex.org/C161457703","wikidata":"https://www.wikidata.org/wiki/Q3317402","display_name":"Renal physiology","level":3,"score":0.5791679620742798},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5786688327789307},{"id":"https://openalex.org/C2775914622","wikidata":"https://www.wikidata.org/wiki/Q284089","display_name":"Carbonic anhydrase","level":3,"score":0.5719914436340332},{"id":"https://openalex.org/C2777405951","wikidata":"https://www.wikidata.org/wiki/Q413690","display_name":"Acetazolamide","level":2,"score":0.43159425258636475},{"id":"https://openalex.org/C68801617","wikidata":"https://www.wikidata.org/wiki/Q162908","display_name":"Electrolyte","level":3,"score":0.4180937707424164},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.36038684844970703},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29467877745628357},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1420169174671173},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13738524913787842},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.12405979633331299},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10242027044296265},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.0999150276184082},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.0},{"id":"https://openalex.org/C194671627","wikidata":"https://www.wikidata.org/wiki/Q192639","display_name":"Glycoside","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1152/ajplegacy.1960.199.1.49","doi":"https://doi.org/10.1152/ajplegacy.1960.199.1.49","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplegacy.1960.199.1.49","pdf_url":null,"source":{"id":"https://openalex.org/S204210209","display_name":"American Journal of Physiology-Legacy Content","issn_l":"0002-9513","issn":["0002-9513","2163-5773"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Legacy Content","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2032441924","https://openalex.org/W2034009652","https://openalex.org/W2265731286","https://openalex.org/W2323307483","https://openalex.org/W2407270016","https://openalex.org/W2071983307","https://openalex.org/W2409919194","https://openalex.org/W7096957447","https://openalex.org/W2154167543","https://openalex.org/W2089341715"],"abstract_inverted_index":{"Strophanthidin,":[0],"a":[1,33,101,124,127,134],"cardiac":[2],"aglycone,":[3],"interferes":[4],"with":[5,68,86],"Na+,":[6,103,136],"K+":[7,45,62,80,104],"and":[8,40,63,81,113,122],"H+":[9,64,82,138],"ion":[10,65,83,139],"transport":[11,84],"by":[12,51],"the":[13,18,25,28,43,98,115,131,142],"renal":[14],"tubule":[15],"cells":[16],"of":[17,21,24,42,54,71,126,133],"chicken.":[19],"Injection":[20],"250\u2013500":[22],"\u00b5g/min.":[23],"aglycone":[26,99],"into":[27],"renal-portal":[29],"circulation":[30],"results":[31],"in":[32,37,61,74,79,110,130],"predominantly":[34],"unilateral":[35],"increase":[36],"Na+":[38,72],"excretion":[39,46],"alkalinization":[41],"urine.":[44],"diminishes":[47],"if":[48],"initially":[49],"elevated":[50],"prior":[52],"administration":[53],"KCl":[55],"or":[56],"K2SO4.":[57],"The":[58,90],"concordant":[59],"changes":[60,117],"secretion":[66],"associated":[67],"depressed":[69],"reabsorption":[70],"are":[73,118],"contrast":[75],"to":[76,108,120],"reciprocal":[77],"alterations":[78],"observed":[85],"carbonic":[87],"anhydrase":[88],"inhibitors.":[89],"data":[91],"have":[92],"been":[93],"interpreted":[94],"as":[95],"indicating":[96],"that":[97,109,114],"inhibits":[100],"contraluminal":[102],"exchange":[105],"pump":[106],"(analogous":[107],"other":[111],"tissues)":[112],"urinary":[116],"secondary":[119],"this":[121],"not":[123],"consequence":[125],"primary":[128],"reduction":[129],"capacity":[132],"linked":[135],"K+,":[137],"exchanger":[140],"on":[141],"luminal":[143],"border.":[144]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}