{"id":"https://openalex.org/W2404893751","doi":"https://doi.org/10.1042/cs0380741","title":"Effect in the Conscious Dog of Constriction of the Renal Artery to a Sole Remaining Kidney on Haemodynamics, Sodium Balance, Body Fluid Volumes, Plasma Renin Concentration and Pressor Responsiveness to Angiotensin","display_name":"Effect in the Conscious Dog of Constriction of the Renal Artery to a Sole Remaining Kidney on Haemodynamics, Sodium Balance, Body Fluid Volumes, Plasma Renin Concentration and Pressor Responsiveness to Angiotensin","publication_year":1970,"publication_date":"1970-06-01","ids":{"openalex":"https://openalex.org/W2404893751","doi":"https://doi.org/10.1042/cs0380741","mag":"2404893751","pmid":"https://pubmed.ncbi.nlm.nih.gov/4317280"},"language":"en","primary_location":{"id":"doi:10.1042/cs0380741","doi":"https://doi.org/10.1042/cs0380741","is_oa":false,"landing_page_url":"https://doi.org/10.1042/cs0380741","pdf_url":null,"source":{"id":"https://openalex.org/S4210219153","display_name":"Clinical Science","issn_l":"0009-9287","issn":["0009-9287"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034705750","display_name":"Giuseppe Bianchi","orcid":"https://orcid.org/0000-0002-8365-3618","observed_orcids":["https://orcid.org/0000-0002-8365-3618"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Bianchi","raw_affiliation_strings":["Istituto di Patologia Speciale Medica dell'Universit\u00e1 di Milano","Laboratori di Farmacologia della Lepetit S.p.A. Milano"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Patologia Speciale Medica dell'Universit\u00e1 di Milano","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Laboratori di Farmacologia della Lepetit S.p.A. Milano","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068258989","display_name":"L. T. Tenconi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Tilde Tenconi","raw_affiliation_strings":["Istituto di Patologia Speciale Medica dell'Universit\u00e1 di Milano","Laboratori di Farmacologia della Lepetit S.p.A. Milano"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Patologia Speciale Medica dell'Universit\u00e1 di Milano","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Laboratori di Farmacologia della Lepetit S.p.A. Milano","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"R. Lucca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R. Lucca","raw_affiliation_strings":["Istituto di Patologia Speciale Medica dell'Universit\u00e1 di Milano","Laboratori di Farmacologia della Lepetit S.p.A. Milano"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Patologia Speciale Medica dell'Universit\u00e1 di Milano","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Laboratori di Farmacologia della Lepetit S.p.A. Milano","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I189158943"],"apc_list":null,"apc_paid":null,"fwci":13.2715,"has_fulltext":false,"cited_by_count":143,"citation_normalized_percentile":{"value":0.98917887,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"38","issue":"6","first_page":"741","last_page":"766"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12067","display_name":"Renal and Vascular Pathologies","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-artery-constriction","display_name":"renal artery constriction","score":0.9340000152587891},{"id":"https://openalex.org/keywords/solitary-kidney","display_name":"solitary kidney","score":0.6880000233650208},{"id":"https://openalex.org/keywords/renal-hypertension","display_name":"renal hypertension","score":0.4869999885559082},{"id":"https://openalex.org/keywords/plasma-renin-concentration","display_name":"plasma renin concentration","score":0.9769999980926514},{"id":"https://openalex.org/keywords/sodium-balance","display_name":"sodium balance","score":0.925000011920929},{"id":"https://openalex.org/keywords/plasma-volume","display_name":"plasma volume","score":0.8379999995231628},{"id":"https://openalex.org/keywords/extracellular-volume","display_name":"extracellular volume","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.9629999995231628},{"id":"https://openalex.org/keywords/systemic-vascular-resistance","display_name":"systemic vascular resistance","score":0.902999997138977},{"id":"https://openalex.org/keywords/blood-pressure-regulation","display_name":"blood pressure regulation","score":0.628000020980835},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.7730000019073486},{"id":"https://openalex.org/keywords/stroke-volume","display_name":"stroke volume","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.7380512952804565},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.703082799911499},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.628501832485199},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.5669431686401367},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5648510456085205},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5497862696647644},{"id":"https://openalex.org/C2113261","wikidata":"https://www.wikidata.org/wiki/Q2914458","display_name":"Extracellular fluid","level":3,"score":0.5480952858924866},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5359585881233215},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.504011332988739},{"id":"https://openalex.org/C174940676","wikidata":"https://www.wikidata.org/wiki/Q495626","display_name":"Constriction","level":2,"score":0.4955059289932251},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.4777338206768036},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47583866119384766},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.45534783601760864},{"id":"https://openalex.org/C37557685","wikidata":"https://www.wikidata.org/wiki/Q1896673","display_name":"Blood volume","level":2,"score":0.4481028914451599},{"id":"https://openalex.org/C2776634560","wikidata":"https://www.wikidata.org/wiki/Q707540","display_name":"Renal artery","level":3,"score":0.4238448143005371},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.35305410623550415},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.34323468804359436},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2712724506855011},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.1336958408355713},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D009392","descriptor_name":"Nephrectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010953","descriptor_name":"Plasma Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012078","descriptor_name":"Renal Artery Obstruction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1042/cs0380741","doi":"https://doi.org/10.1042/cs0380741","is_oa":false,"landing_page_url":"https://doi.org/10.1042/cs0380741","pdf_url":null,"source":{"id":"https://openalex.org/S4210219153","display_name":"Clinical Science","issn_l":"0009-9287","issn":["0009-9287"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},{"id":"pmid:4317280","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4317280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1577856337","https://openalex.org/W1983360410","https://openalex.org/W1985675228","https://openalex.org/W1990377808","https://openalex.org/W2001350565","https://openalex.org/W2010135034","https://openalex.org/W2018382278","https://openalex.org/W2041060927","https://openalex.org/W2061412546","https://openalex.org/W2061970621","https://openalex.org/W2064754830","https://openalex.org/W2087690474","https://openalex.org/W2088716433","https://openalex.org/W2090518440","https://openalex.org/W2094398755","https://openalex.org/W2097338608","https://openalex.org/W2114194398","https://openalex.org/W2131168647","https://openalex.org/W2140909944","https://openalex.org/W2142285732","https://openalex.org/W2142911603","https://openalex.org/W2143297134","https://openalex.org/W2214765689","https://openalex.org/W2252357207","https://openalex.org/W2255794856","https://openalex.org/W2278223323","https://openalex.org/W2278285620","https://openalex.org/W2285436864","https://openalex.org/W2297358362","https://openalex.org/W2324686390","https://openalex.org/W2327495185","https://openalex.org/W2395559088","https://openalex.org/W2402571969","https://openalex.org/W2409338832","https://openalex.org/W2410202639","https://openalex.org/W2411780748","https://openalex.org/W2412766690","https://openalex.org/W2415863056","https://openalex.org/W2419717670","https://openalex.org/W2425630780","https://openalex.org/W2763950886","https://openalex.org/W3028233464","https://openalex.org/W4255921896","https://openalex.org/W4407042125"],"related_works":["https://openalex.org/W2301831189","https://openalex.org/W2331006012","https://openalex.org/W2045838701","https://openalex.org/W2051642323","https://openalex.org/W2145487372","https://openalex.org/W2061970621","https://openalex.org/W2403463167","https://openalex.org/W2059302124","https://openalex.org/W2066706088","https://openalex.org/W7100154594"],"abstract_inverted_index":{"1.":[0],"The":[1,15,108],"renal":[2],"artery":[3],"to":[4,165,172,213,241,273,275,324],"a":[5,84,147,166,214],"lone":[6],"remaining":[7],"kidney":[8],"was":[9,47,71,137,229],"constricted":[10],"in":[11,20,49,65,73,98,132,197,235,263,282],"fourteen":[12],"concious":[13],"dogs.":[14,51,67,267],"following":[16,81],"variables":[17,187],"were":[18,63,105,224,280],"measured":[19,64,72,281],"all":[21,265],"animals:":[22],"blood":[23,298],"pressure":[24,299],"(BP),":[25],"cardiac":[26],"rate":[27],"(CR),":[28],"plasma":[29,33,41],"renin":[30,131],"concentration":[31],"(PRC),":[32],"volume":[34,38,61],"(PV),":[35],"extracellular":[36],"fluid":[37],"(ECFV)":[39],"and":[40,59,90,100,103,156,158,196,206,222,247,269,278],"non-protein":[42],"nitrogen":[43],"(NPN).":[44],"Sodium":[45],"balance":[46,228,246,254],"estimated":[48],"eleven":[50],"Cardiac":[52],"output":[53],"(CO),":[54],"total":[55],"peripheral":[56],"resistence":[57],"(TPR)":[58],"stroke":[60],"(SV)":[62],"nine":[66],"Angiotensin":[68],"responsiveness":[69],"(AR)":[70],"six":[74],"animals.":[75],"2.":[76],"Within":[77],"2":[78,141],"hr":[79,146],"the":[80,122,127,133,181,236,266,294,304,312,314,319,325,328],"changes":[82,113,116,242],"occurred:":[83],"sharp":[85],"increment":[86],"of":[87,111,129,168,216,243,297,306,316,321,327],"BP,":[88],"PRC":[89,115,170,258],"TPR,":[91],"with":[92,318],"initial":[93],"reduction":[94],"or":[95],"no":[96],"change":[97],"CO":[99,161,210,277,322],"CR;":[101],"SV":[102,159],"PV":[104,155,221,268,317],"not":[106,118],"changed.":[107],"linear":[109,182],"regression":[110,183],"BP":[112,177],"on":[114],"did":[117],"differ":[119],"statistically":[120],"from":[121],"one":[123],"previously":[124],"obtained":[125],"during":[126],"infusion":[128],"exogenous":[130],"conscious":[134],"dog.":[135],"AR":[136,192,231,279],"much":[138,234],"depressed":[139],"at":[140,286],"hr.":[142],"3.":[143],"After":[144],"24":[145],"slight":[148],"but":[149],"significant":[150],"sodium":[151,227,245,253],"retention":[152],"developed,":[153],"while":[154,176,218,226,308],"ECFV":[157,223,270],"increased,":[160],"remained":[162,178],"unchanged":[163],"owing":[164,212],"decrease":[167,274],"CR.":[169],"tended":[171,272],"return":[173],"toward":[174,194],"normal":[175,195,261],"high.":[179],"Thus":[180],"between":[184],"these":[185],"two":[186,198,284],"disappeared.":[188],"At":[189],"this":[190,287],"stage":[191],"increased":[193,211],"dogs":[199,238,285],"exceeded":[200],"normal.":[201,276],"4.":[202],"On":[203,250],"days":[204,251,310],"3\u20134":[205],"6\u20137":[207],"after":[208,311],"constriction,":[209],"rise":[215,296],"SV,":[217],"TPR":[219],"decreased.":[220],"expanded":[225],"maintained.":[230],"varied":[232],"very":[233],"individual":[237],"according":[239],"mainly":[240],"PRC,":[244,307],"PV.":[248],"5.":[249],"12\u201314":[252],"became":[255],"positive":[256],"again,":[257],"returned":[259],"within":[260],"levels":[262],"almost":[264],"also":[271],"only":[283],"stage.":[288],"6.":[289],"It":[290],"is":[291],"suggested":[292],"that":[293],"early":[295],"might":[300],"be":[301],"produced":[302],"by":[303],"increase":[305,320],"3\u20136":[309],"constriction":[313],"expansion":[315],"contributed":[323],"maintenance":[326],"hypertension.":[329]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
