{"id":"https://openalex.org/W2404866097","doi":null,"title":"[Expression of co-stimulators in ulcerative colitis and its pathologic significance].","display_name":"[Expression of co-stimulators in ulcerative colitis and its pathologic significance].","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2404866097","mag":"2404866097","pmid":"https://pubmed.ncbi.nlm.nih.gov/20388394"},"language":"zh","primary_location":{"id":"pmid:20388394","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20388394","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua bing li xue za zhi = Chinese journal of pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100710377","display_name":"Li Fang","orcid":"https://orcid.org/0000-0002-1076-7729","observed_orcids":["https://orcid.org/0000-0002-1076-7729"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Li","raw_affiliation_strings":["Department of Pathology, Peking University School of Basic Medical Science, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Peking University School of Basic Medical Science, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028400106","display_name":"A-jing Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"A-jing Chen","raw_affiliation_strings":["Department of Pathology, Peking University School of Basic Medical Science, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Peking University School of Basic Medical Science, Beijing 100191, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041479429","display_name":"Juan Du","orcid":"https://orcid.org/0000-0002-1850-3613","observed_orcids":["https://orcid.org/0000-0002-1850-3613"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Du","raw_affiliation_strings":["Department of Pathology, Peking University School of Basic Medical Science, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Peking University School of Basic Medical Science, Beijing 100191, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100456135","display_name":"Yan Zhang","orcid":"https://orcid.org/0000-0001-7105-4661","observed_orcids":["https://orcid.org/0000-0001-7105-4661"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Zhang","raw_affiliation_strings":["Department of Pathology, Peking University School of Basic Medical Science, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Peking University School of Basic Medical Science, Beijing 100191, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005035441","display_name":"Encong Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"En-cong Gong","raw_affiliation_strings":["Department of Pathology, Peking University School of Basic Medical Science, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Peking University School of Basic Medical Science, Beijing 100191, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044777574","display_name":"Xueying Shi","orcid":"https://orcid.org/0000-0003-0384-560X","observed_orcids":["https://orcid.org/0000-0003-0384-560X"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue-ying Shi","raw_affiliation_strings":["Department of Pathology, Peking University School of Basic Medical Science, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Peking University School of Basic Medical Science, Beijing 100191, China","institution_ids":["https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I20231570"],"apc_list":null,"apc_paid":null,"fwci":0.2839,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.70583346,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"39","issue":"1","first_page":"19","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13569","display_name":"Microscopic Colitis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.996999979019165},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":0.996999979019165},{"id":"https://openalex.org/keywords/inducible-t-cell-costimulator","display_name":"ICOS","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cd28","display_name":"CD28","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lamina-propria-mononuclear-cells","display_name":"lamina propria mononuclear cells","score":0.8939999938011169},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/intraepithelial-lymphocytes","display_name":"intraepithelial lymphocytes","score":0.925000011920929},{"id":"https://openalex.org/keywords/cd4-cd8-ratio","display_name":"CD4/CD8 ratio","score":0.9589999914169312},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.6430000066757202},{"id":"https://openalex.org/keywords/mucosal-inflammation","display_name":"mucosal inflammation","score":0.621999979019165},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.5600000023841858},{"id":"https://openalex.org/keywords/colonic-mucosa","display_name":"colonic mucosa","score":0.4259999990463257},{"id":"https://openalex.org/keywords/immunopathogenesis","display_name":"immunopathogenesis","score":0.5640000104904175},{"id":"https://openalex.org/keywords/cd4","display_name":"CD4","score":0.30399999022483826},{"id":"https://openalex.org/keywords/cd8","display_name":"CD8","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C2777310793","wikidata":"https://www.wikidata.org/wiki/Q1725675","display_name":"Lamina propria","level":3,"score":0.8709002137184143},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.7986240983009338},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6074239611625671},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.5872839689254761},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5603663921356201},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.5098230242729187},{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.49873948097229004},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47833678126335144},{"id":"https://openalex.org/C18031839","wikidata":"https://www.wikidata.org/wiki/Q5009796","display_name":"CD20","level":3,"score":0.45378634333610535},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4468933045864105},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39973339438438416},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.3168025612831116},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3167860805988312},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3082195222377777},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.24732160568237305},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.23718109726905823},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09378626942634583},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000945","descriptor_name":"Antigens, Differentiation, T-Lymphocyte","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016516","descriptor_name":"CD4-CD8 Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018106","descriptor_name":"CD28 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051940","descriptor_name":"B7-2 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060889","descriptor_name":"Inducible T-Cell Co-Stimulator Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:20388394","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20388394","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua bing li xue za zhi = Chinese journal of pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2041339758","https://openalex.org/W2368133673","https://openalex.org/W2325682891","https://openalex.org/W2062641782","https://openalex.org/W2359058443","https://openalex.org/W7100941709","https://openalex.org/W2065158037","https://openalex.org/W2350012648","https://openalex.org/W2355247089","https://openalex.org/W2355842415"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"study":[2],"the":[3,10,24,121,131,156,196,207,260,284,331,351],"expression":[4,92,106,139,164,186,208,223,345],"and":[5,18,33,56,85,96,130,155,219,235,256,263,277,315,326,335],"localization":[6],"of":[7,12,26,30,93,107,179,187,209,224,250,286,298,346,353],"co-stimulators":[8,31,347],"in":[9,23,113,120,140,147,165,172,191,195,226,232,259,270,274,290,302,308,312,330,357],"mucosa":[11],"patients":[13,46,75],"with":[14,47,76,127,152,177,230],"ulcerative":[15],"colitis":[16],"(UC),":[17],"to":[19,350],"explore":[20],"its":[21],"role":[22],"pathogenesis":[25],"UC.":[27,358],"METHODS:":[28],"Expression":[29],"CD86":[32,108,188,325],"inducible":[34],"co-stimulator":[35],"(ICOS)":[36],"was":[37,64,109,145,169,189,238,267,288,305],"studied":[38],"by":[39],"immunohistochemistry":[40],"on":[41,68],"paraffin-embedded":[42],"mucosal":[43,71],"tissue":[44,72],"from":[45,74],"active":[48,77,103,148,173,227,271,291,309,323],"UC":[49,53,78,82,129,154,181,193,218,234,272,276,292,310,314],"(64":[50],"cases),":[51,80],"inactive":[52,81,128,153,180,192,217,233,275,313],"(51":[54],"cases)":[55,84],"normal":[57,86,132,157,197,220,236,278,316],"controls":[58,87,133,158,198,279,317],"(20":[59],"cases).":[60,89],"Immunostaining":[61],"for":[62],"CD28":[63,225],"also":[65,99,119,170,239,306],"carried":[66],"out":[67],"frozen":[69],"fresh":[70],"sampled":[73],"(7":[79],"(2":[83],"(5":[88],"In":[90,102,322],"addition,":[91],"CD4,":[94],"CD8":[95],"CD20":[97],"were":[98,328],"examined.":[100],"RESULTS:":[101],"UC,":[104,149,174,228,324],"increased":[105],"not":[110],"only":[111],"observed":[112],"lamina":[114,141,261,303,336],"propria":[115,142,262,304,337],"mononuclear":[116,143,338],"cells":[117,144,168,334],"but":[118],"intestinal":[122,166,332],"epithelial":[123,167,333],"cells,":[124],"as":[125,150,175],"compared":[126,151,176,229],"(P":[134,159,182,199,241,280,293,318],"<":[135,160,183,200,204,242,246,281,294,319],"0.01).":[136,161,184,205,247,282,295,320],"Increased":[137,162,222],"ICOS":[138,163,210,327],"detected":[146],"seen":[171],"that":[178,231,343],"The":[185,248,296,340],"higher":[190,269,307],"than":[194,273,311],"0.05":[201,243],"or":[202,244,252],"P":[203,245],"However,":[206],"showed":[211],"no":[212],"statistically":[213],"significant":[214],"difference":[215],"between":[216],"controls.":[221],"controls,":[237],"noticed":[240],"number":[249,297],"CD4":[251],"CD8-positive":[253],"intraepithelial":[254],"lymphocytes":[255,257,301],"infiltrating":[258],"small":[264],"vessel":[265],"walls":[266],"much":[268],"Moreover,":[283],"ratio":[285],"CD4/CD8":[287],"highest":[289],"CD20-positive":[299],"B":[300],"CONCLUSIONS:":[321],"over-expressed":[329],"cells.":[339],"phenomenon":[341],"suggests":[342],"abnormal":[344],"may":[348],"contribute":[349],"deregulation":[352],"acquired":[354],"immune":[355],"responses":[356]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}