{"id":"https://openalex.org/W2404862496","doi":null,"title":"Activation of unfolded protein response protects osteosarcoma cells from cisplatin-induced apoptosis through NF-\u03baB pathway.","display_name":"Activation of unfolded protein response protects osteosarcoma cells from cisplatin-induced apoptosis through NF-\u03baB pathway.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2404862496","mag":"2404862496","pmid":"https://pubmed.ncbi.nlm.nih.gov/26617729","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4637544"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4637544","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4637544","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4637544","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112316339","display_name":"Mingming Yan","orcid":"https://orcid.org/0009-0007-6325-7507","observed_orcids":["https://orcid.org/0009-0007-6325-7507"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingming Yan","raw_affiliation_strings":["Department of Orthopeadic Surgery, The Second Xiangya Hospital, Central South University Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopeadic Surgery, The Second Xiangya Hospital, Central South University Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082311510","display_name":"Jiangdong Ni","orcid":"https://orcid.org/0000-0001-6196-0185","observed_orcids":["https://orcid.org/0000-0001-6196-0185"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiangdong Ni","raw_affiliation_strings":["Department of Orthopeadic Surgery, The Second Xiangya Hospital, Central South University Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopeadic Surgery, The Second Xiangya Hospital, Central South University Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112125661","display_name":"Deye Song","orcid":"https://orcid.org/0000-0001-5899-9767","observed_orcids":["https://orcid.org/0000-0001-5899-9767"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Deye Song","raw_affiliation_strings":["Department of Orthopeadic Surgery, The Second Xiangya Hospital, Central South University Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopeadic Surgery, The Second Xiangya Hospital, Central South University Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014049196","display_name":"Muliang Ding","orcid":"https://orcid.org/0000-0002-4927-2766","observed_orcids":["https://orcid.org/0000-0002-4927-2766"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Muliang Ding","raw_affiliation_strings":["Department of Orthopeadic Surgery, The Second Xiangya Hospital, Central South University Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopeadic Surgery, The Second Xiangya Hospital, Central South University Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856","https://openalex.org/I4210159865"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026792899","display_name":"Jun Xing Huang","orcid":"https://orcid.org/0000-0002-4798-6191","observed_orcids":["https://orcid.org/0000-0002-4798-6191"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Huang","raw_affiliation_strings":["Department of Orthopeadic Surgery, The Second Xiangya Hospital, Central South University Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopeadic Surgery, The Second Xiangya Hospital, Central South University Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856","https://openalex.org/I4210159865"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.507,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.79532694,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"9","first_page":"10204","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.996999979019165},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.9769999980926514},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9279999732971191},{"id":"https://openalex.org/keywords/grp78","display_name":"GRP78","score":0.9539999961853027},{"id":"https://openalex.org/keywords/chop","display_name":"CHOP","score":1.0},{"id":"https://openalex.org/keywords/4-phenylbutyrate","display_name":"4-phenylbutyric acid","score":0.9269999861717224},{"id":"https://openalex.org/keywords/bay-11-7082","display_name":"BAY 11-7082","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.5659999847412109},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.328000009059906}],"concepts":[{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.8969501256942749},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8064788579940796},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.6598759889602661},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.6109792590141296},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.6058876514434814},{"id":"https://openalex.org/C2779725641","wikidata":"https://www.wikidata.org/wiki/Q1076228","display_name":"CHOP","level":3,"score":0.5941383242607117},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.586553156375885},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5440998077392578},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4913734495639801},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.45814651250839233},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.346884548664093},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3454396724700928},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.116554856300354},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.08295190334320068},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000091342","descriptor_name":"Endoplasmic Reticulum Chaperone BiP","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056811","descriptor_name":"Unfolded Protein Response","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D056811","descriptor_name":"Unfolded Protein Response","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4637544","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4637544","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"pmid:26617729","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26617729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"mag:2404862496","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26617729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:3149219472","doi":null,"is_oa":false,"landing_page_url":"http://or.nsfc.gov.cn/bitstream/00001903-5/508951/1/1000014006992.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4637544","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4637544","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W23832024","https://openalex.org/W1581923494","https://openalex.org/W1967627036","https://openalex.org/W1976478217","https://openalex.org/W1979733074","https://openalex.org/W1985515729","https://openalex.org/W1986856096","https://openalex.org/W1996543107","https://openalex.org/W2001007571","https://openalex.org/W2001399725","https://openalex.org/W2002439304","https://openalex.org/W2003724895","https://openalex.org/W2003977015","https://openalex.org/W2004672646","https://openalex.org/W2006201075","https://openalex.org/W2007456673","https://openalex.org/W2008373622","https://openalex.org/W2011551652","https://openalex.org/W2024493194","https://openalex.org/W2028928387","https://openalex.org/W2033588946","https://openalex.org/W2037908592","https://openalex.org/W2039810057","https://openalex.org/W2052464502","https://openalex.org/W2057651711","https://openalex.org/W2062918974","https://openalex.org/W2077885909","https://openalex.org/W2083034155","https://openalex.org/W2089198803","https://openalex.org/W2093535002","https://openalex.org/W2100347985","https://openalex.org/W2101049762","https://openalex.org/W2112286580","https://openalex.org/W2118483041","https://openalex.org/W2120535935","https://openalex.org/W2127684300","https://openalex.org/W2127820455","https://openalex.org/W2129163103","https://openalex.org/W2131695680","https://openalex.org/W2145028653","https://openalex.org/W2148943471","https://openalex.org/W2157744411","https://openalex.org/W2160904849","https://openalex.org/W2168788774","https://openalex.org/W2169172001","https://openalex.org/W2187803837","https://openalex.org/W2192080449"],"related_works":["https://openalex.org/W3149219472","https://openalex.org/W2090017335","https://openalex.org/W4206089664","https://openalex.org/W2257639774","https://openalex.org/W7098185358","https://openalex.org/W2782308810","https://openalex.org/W2599073766","https://openalex.org/W2773050945","https://openalex.org/W4249714117","https://openalex.org/W2044604032"],"abstract_inverted_index":{"The":[0],"aim":[1],"of":[2,17,35,56,93,122,128,141,151,196],"this":[3],"study":[4],"was":[5],"to":[6,14,29,47,83,104,173,207],"uncover":[7],"that":[8,136,174,187],"unfolded":[9],"protein":[10,59,64],"response":[11],"(UPR)":[12],"contributed":[13],"the":[15,49,106,118,126,139,148,209],"development":[16],"cisplatin":[18,30,84,123,137,180],"resistance":[19],"in":[20,155,175],"osteosarcoma.":[21],"MG-63":[22,76,165],"cells":[23,26,77,80,166,169,177],"and":[24,38,44,53,67,78,99,110,113,130,167],"SaOS-2":[25,79,168],"were":[27,70,81,102],"exposed":[28],"at":[31],"presence":[32],"or":[33,86],"absence":[34],"4-phenylbutyrayte":[36],"(4-pba)":[37],"then":[39],"analyzed":[40],"by":[41,72,179],"MTT":[42,97],"assay":[43,98],"flow":[45,100],"cytometry":[46,101],"determine":[48,105],"cell":[50,107,119],"survival":[51,108],"rates":[52,109],"apoptosis.":[54,111,120],"Levels":[55],"glucose":[57],"regulated":[58],"78KD":[60],"(GRP78),":[61],"C/EBP":[62],"homologus":[63],"(CHOP),":[65],"cytoplasmic":[66],"nuclear":[68,142,152],"NF-\u03baB":[69,143,153,197],"detected":[71],"Western":[73],"blot.":[74],"Further,":[75],"subjected":[82],"with":[85,160],"without":[87],"Bay":[88,161],"11-7082,":[89],"a":[90,204],"well-known":[91],"inhibitor":[92],"NF-\u03baB.":[94],"After":[95],"that,":[96],"used":[103],"Cisplatin":[112,158],"4-PBA":[114,145],"co-treatment":[115],"significantly":[116],"enhanced":[117],"Administration":[121],"substantially":[124],"increased":[125],"levels":[127,140],"GRP78":[129],"CHOP.":[131],"Moreover,":[132],"mechanistic":[133],"investigation":[134],"uncovered":[135],"promoted":[138],"whereas":[144],"administration":[146],"suppressed":[147],"cisplatin-induced":[149],"accumulation":[150],"level":[154],"osteosarcoma":[156,176,190,210],"cells.":[157],"combined":[159],"11-7082":[162],"obviously":[163],"augmented":[164],"apoptosis":[170,193],"when":[171],"compared":[172],"treated":[178],"alone.":[181],"Taken":[182],"together,":[183],"our":[184],"data":[185],"show":[186],"UPR":[188,201],"protects":[189],"from":[191],"cisplatin-mediated":[192],"through":[194],"activation":[195],"pathway.":[198],"Therefore,":[199],"targeting":[200],"may":[202],"be":[203],"potential":[205],"strategy":[206],"improve":[208],"therapy.":[211]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
