{"id":"https://openalex.org/W2404765632","doi":null,"title":"Progress in clinical chemoprevention.","display_name":"Progress in clinical chemoprevention.","publication_year":1997,"publication_date":"1997-04-01","ids":{"openalex":"https://openalex.org/W2404765632","mag":"2404765632","pmid":"https://pubmed.ncbi.nlm.nih.gov/9129692"},"language":"en","primary_location":{"id":"pmid:9129692","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9129692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in oncology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048308941","display_name":"Gary J. Kelloff","orcid":"https://orcid.org/0000-0002-5656-4900","observed_orcids":["https://orcid.org/0000-0002-5656-4900"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G J Kelloff","raw_affiliation_strings":["Division of Cancer Prevention and Control, Chemoprevention Branch, National Cancer Institute, Bethesda, MD 20852, USA","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Prevention and Control, Chemoprevention Branch, National Cancer Institute, Bethesda, MD 20852, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015008352","display_name":"Ernest T. Hawk","orcid":"https://orcid.org/0000-0002-9062-7338","observed_orcids":["https://orcid.org/0000-0002-9062-7338"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E T Hawk","raw_affiliation_strings":["Clinical Cancer Prevention"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Cancer Prevention","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040758762","display_name":"Judith E. Karp","orcid":"https://orcid.org/0000-0003-4754-127X","observed_orcids":["https://orcid.org/0000-0003-4754-127X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J E Karp","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113560256","display_name":"James A. Crowell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A Crowell","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111645316","display_name":"Charles W. Boone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C W Boone","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109095551","display_name":"Vernon E. Steele","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V E Steele","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014024059","display_name":"Ronald A. Lubet","orcid":"https://orcid.org/0000-0003-1957-7945","observed_orcids":["https://orcid.org/0000-0003-1957-7945"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R A Lubet","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059928711","display_name":"Caroline C. Sigman","orcid":"https://orcid.org/0000-0001-6623-4107","observed_orcids":["https://orcid.org/0000-0001-6623-4107"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C C Sigman","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.3364,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.98347613,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"24","issue":"2","first_page":"241","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13656","display_name":"Science, Research, and Medicine","score":0.19580000638961792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13656","display_name":"Science, Research, and Medicine","score":0.19580000638961792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.13439999520778656,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.09549999982118607,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8989999890327454},{"id":"https://openalex.org/keywords/intermediate-biomarkers","display_name":"intermediate biomarkers","score":0.9160000085830688},{"id":"https://openalex.org/keywords/surrogate-endpoints","display_name":"surrogate endpoints","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cancer-incidence","display_name":"cancer incidence","score":0.6299999952316284},{"id":"https://openalex.org/keywords/precancerous-lesions","display_name":"precancerous lesions","score":0.8410000205039978},{"id":"https://openalex.org/keywords/genetic-susceptibility-to-cancer","display_name":"genetic susceptibility to cancer","score":0.7429999709129333},{"id":"https://openalex.org/keywords/carcinogenesis-mechanisms","display_name":"carcinogenesis mechanisms","score":0.8240000009536743},{"id":"https://openalex.org/keywords/human-genome-project","display_name":"Human Genome Project","score":0.6349999904632568},{"id":"https://openalex.org/keywords/fda-guidance","display_name":"FDA guidance","score":0.6100000143051147},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8442295789718628},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.6186935901641846},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6177349090576172},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5764874815940857},{"id":"https://openalex.org/C2780234812","wikidata":"https://www.wikidata.org/wiki/Q1787013","display_name":"Cancer prevention","level":3,"score":0.5545140504837036},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5453968644142151},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.44218623638153076},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.43218275904655457},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3918799161911011},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3425687551498413},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2709251344203949},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.24315473437309265},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2207859456539154},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08319392800331116},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005069","descriptor_name":"Evaluation Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D010601","descriptor_name":"Pharmacology, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015507","descriptor_name":"Drugs, Investigational","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015507","descriptor_name":"Drugs, Investigational","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9129692","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9129692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in oncology","raw_type":"Journal Article"},{"id":"mag:2404765632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9129692","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2163131487","https://openalex.org/W2422250357","https://openalex.org/W1508025216","https://openalex.org/W1966965133","https://openalex.org/W2000879602","https://openalex.org/W1975300655","https://openalex.org/W4236852184","https://openalex.org/W2102231941","https://openalex.org/W2045617306","https://openalex.org/W186453390"],"abstract_inverted_index":{"Chemoprevention":[0],"has":[1,40,56],"four":[2],"goals:":[3],"(1)":[4],"inhibition":[5],"of":[6,20,28,81,84,145,170],"carcinogens,":[7],"(2)":[8],"logical":[9],"intervention":[10,34,194,207],"for":[11,16,47,69,93,161,192,206],"persons":[12],"at":[13,197],"genetic":[14,198],"risk":[15,199],"cancer,":[17],"(3)":[18],"treatment":[19],"precancerous":[21],"lesions,":[22],"and":[23,26,55,62,79,86,116,137,147,176,188,200],"(4)":[24],"confirmation":[25],"translation":[27],"leads":[29,153],"from":[30,180],"dietary":[31],"epidemiology":[32],"into":[33],"strategies.":[35,208],"The":[36,141],"National":[37],"Cancer":[38],"Institute":[39],"described":[41],"a":[42],"multidisciplinary,":[43],"cancer":[44,85,94],"science-based":[45],"program":[46,106],"chemopreventive":[48,156,193],"drug":[49],"development":[50,112],"that":[51],"addresses":[52],"these":[53],"objectives,":[54],"collaborated":[57],"with":[58,127,158],"the":[59,77,105,110,128,181,190],"US":[60],"Food":[61],"Drug":[63],"Administration":[64],"to":[65,135,154],"provide":[66,152,202],"consensus":[67],"guidance":[68],"applying":[70],"this":[71],"approach.":[72],"A":[73],"critical":[74],"component":[75],"is":[76],"identification":[78],"characterization":[80],"intermediate":[82,139],"biomarkers":[83],"their":[87],"validation":[88],"as":[89],"surrogate":[90],"end":[91],"points":[92],"incidence":[95],"in":[96,104,131,195],"clinical":[97,111,119],"chemoprevention":[98],"trials.":[99],"More":[100],"than":[101],"40":[102],"agents":[103,157],"are":[107],"currently":[108],"on":[109,173],"path":[113],"(preclinical":[114],"toxicology":[115],"phase":[117,123,132],"I":[118],"safety":[120],"studies":[121,134],"or":[122],"II/III":[124],"efficacy":[125],"trials),":[126],"major":[129],"effort":[130],"II":[133],"identify":[136,187],"characterize":[138],"biomarkers.":[140],"continually":[142],"advancing":[143],"knowledge":[144],"molecular":[146],"tissue-based":[148],"carcinogenesis":[149],"mechanisms":[150],"will":[151,185,201],"new":[155],"increased":[159],"specificity":[160],"carcinogenesis-related":[162],"activities":[163],"and,":[164],"hence,":[165],"reduced":[166],"toxicity":[167],"by":[168],"virtue":[169],"minimal":[171],"effects":[172],"normal":[174],"cell":[175],"tissue":[177],"functions.":[178],"Results":[179],"Human":[182],"Genome":[183],"Project":[184],"help":[186],"evaluate":[189],"potential":[191],"cohorts":[196],"specific":[203],"target":[204],"lesions":[205]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
