{"id":"https://openalex.org/W2404724331","doi":null,"title":"[Cultured cell systems for revelation of new drugs antiatherosclerotic effects and their mechanisms investigation].","display_name":"[Cultured cell systems for revelation of new drugs antiatherosclerotic effects and their mechanisms investigation].","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2404724331","mag":"2404724331","pmid":"https://pubmed.ncbi.nlm.nih.gov/22629858"},"language":"ru","primary_location":{"id":"pmid:22629858","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22629858","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Patologicheskaia fiziologiia i eksperimental'naia terapiia","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102778497","display_name":"Alexander Nikolaevich Orekhov","orcid":"https://orcid.org/0000-0002-6495-1628","observed_orcids":["https://orcid.org/0000-0002-6495-1628"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A N Orekhov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077715103","display_name":"Igor Alexandrovich Sobenin","orcid":"https://orcid.org/0000-0003-0978-6444","observed_orcids":["https://orcid.org/0000-0003-0978-6444"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I A Sobenin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111182333","display_name":"Varvara Alexandrovna Orekhova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V A Orekhova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111182422","display_name":"Alexandra Alexandrovna Melnichenko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A A Mel'nichenko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065230538","display_name":"Veronika A. Myasoedova","orcid":"https://orcid.org/0000-0001-8414-5300","observed_orcids":["https://orcid.org/0000-0001-8414-5300"]},"institutions":[{"id":"https://openalex.org/I4210089474","display_name":"Centro Cardiologico Monzino","ror":"https://ror.org/006pq9r08","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210089474","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"V A Miasoedova","raw_affiliation_strings":["Centro Cardiologico Monzino"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Cardiologico Monzino","institution_ids":["https://openalex.org/I4210089474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084261994","display_name":"Mukhamedova Nm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N M Mukhamedova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070706388","display_name":"Martirosian Dm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D M Martirosian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047910628","display_name":"Alexey V. Pshezhetsky","orcid":"https://orcid.org/0000-0002-6612-1062","observed_orcids":["https://orcid.org/0000-0002-6612-1062"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A V Pshezhetski\u012d","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023341344","display_name":"\u0412 \u041f \u041a\u0430\u0440\u0430\u0433\u043e\u0434\u0438\u043d","orcid":"https://orcid.org/0000-0003-0501-8499","observed_orcids":["https://orcid.org/0000-0003-0501-8499"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V P Karagodin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1269,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.44275314,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":"1","first_page":"33","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cholesterol-efflux","display_name":"cholesterol efflux","score":0.8659999966621399},{"id":"https://openalex.org/keywords/reverse-cholesterol-transport","display_name":"reverse cholesterol transport","score":0.9860000014305115},{"id":"https://openalex.org/keywords/arterial-wall","display_name":"arterial wall","score":0.9049999713897705},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.652999997138977},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.7627462148666382},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7355791330337524},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.6831005811691284},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5754333138465881},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4470135271549225},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.425462543964386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31248944997787476},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23786574602127075},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.12132993340492249}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22629858","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22629858","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Patologicheskaia fiziologiia i eksperimental'naia terapiia","raw_type":"English Abstract"},{"id":"mag:2404724331","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22629858","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7217360608","https://openalex.org/W2071956406","https://openalex.org/W2242225961","https://openalex.org/W2546023504","https://openalex.org/W2023672248","https://openalex.org/W2067256607","https://openalex.org/W127951395","https://openalex.org/W2282803506","https://openalex.org/W4293579134","https://openalex.org/W3150677530"],"abstract_inverted_index":{"Cultured":[0],"cell":[1],"models":[2,24],"have":[3],"been":[4],"developed":[5],"to":[6,38],"study":[7],"the":[8,12,26],"cholesterol":[9,21],"efflux":[10],"from":[11],"arterial":[13],"wall":[14],"as":[15],"an":[16],"integral":[17],"indicator":[18],"of":[19,28,47],"reverse":[20],"transport.":[22],"The":[23],"and":[25,31,43],"results":[27],"in":[29],"vivo":[30,33],"ex":[32],"experiments":[34],"can":[35],"be":[36],"used":[37],"propose":[39],"new":[40],"antiatherosclerotic":[41],"drugs":[42],"elucidate":[44],"their":[45],"mood":[46],"action.":[48]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}