{"id":"https://openalex.org/W2404616178","doi":"https://doi.org/10.1128/aac.00576-16","title":"A Transposon Screen Identifies Genetic Determinants of Vibrio cholerae Resistance to High-Molecular-Weight Antibiotics","display_name":"A Transposon Screen Identifies Genetic Determinants of Vibrio cholerae Resistance to High-Molecular-Weight Antibiotics","publication_year":2016,"publication_date":"2016-05-24","ids":{"openalex":"https://openalex.org/W2404616178","doi":"https://doi.org/10.1128/aac.00576-16","mag":"2404616178","pmid":"https://pubmed.ncbi.nlm.nih.gov/27216069","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4958186"},"language":"en","primary_location":{"id":"doi:10.1128/aac.00576-16","doi":"https://doi.org/10.1128/aac.00576-16","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00576-16","pdf_url":"https://aac.asm.org/content/aac/60/8/4757.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aac.asm.org/content/aac/60/8/4757.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052038207","display_name":"Tobias D\u00f6rr","orcid":"https://orcid.org/0000-0003-3283-9161","observed_orcids":["https://orcid.org/0000-0003-3283-9161"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tobias D\u00f6rr","raw_affiliation_strings":["Howard Hughes Medical Institute, Brigham and Women's Hospital Division of Infectious Diseases and Harvard Medical School Department of Microbiology and Immunobiology, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Brigham and Women's Hospital Division of Infectious Diseases and Harvard Medical School Department of Microbiology and Immunobiology, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109490483","display_name":"Fernanda Delgado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fernanda Delgado","raw_affiliation_strings":["Howard Hughes Medical Institute, Brigham and Women's Hospital Division of Infectious Diseases and Harvard Medical School Department of Microbiology and Immunobiology, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Brigham and Women's Hospital Division of Infectious Diseases and Harvard Medical School Department of Microbiology and Immunobiology, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028503228","display_name":"Benjamin D. Umans","orcid":"https://orcid.org/0000-0002-8209-9731","observed_orcids":["https://orcid.org/0000-0002-8209-9731"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin D. Umans","raw_affiliation_strings":["Howard Hughes Medical Institute, Brigham and Women's Hospital Division of Infectious Diseases and Harvard Medical School Department of Microbiology and Immunobiology, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Brigham and Women's Hospital Division of Infectious Diseases and Harvard Medical School Department of Microbiology and Immunobiology, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007073069","display_name":"Matthew A. Gerding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew A. Gerding","raw_affiliation_strings":["Howard Hughes Medical Institute, Brigham and Women's Hospital Division of Infectious Diseases and Harvard Medical School Department of Microbiology and Immunobiology, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Brigham and Women's Hospital Division of Infectious Diseases and Harvard Medical School Department of Microbiology and Immunobiology, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017683749","display_name":"Brigid M. Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brigid M. Davis","raw_affiliation_strings":["Howard Hughes Medical Institute, Brigham and Women's Hospital Division of Infectious Diseases and Harvard Medical School Department of Microbiology and Immunobiology, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Brigham and Women's Hospital Division of Infectious Diseases and Harvard Medical School Department of Microbiology and Immunobiology, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067108842","display_name":"Matthew K. Waldor","orcid":"https://orcid.org/0000-0003-1843-7000","observed_orcids":["https://orcid.org/0000-0003-1843-7000"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew K. Waldor","raw_affiliation_strings":["Howard Hughes Medical Institute, Brigham and Women's Hospital Division of Infectious Diseases and Harvard Medical School Department of Microbiology and Immunobiology, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Brigham and Women's Hospital Division of Infectious Diseases and Harvard Medical School Department of Microbiology and Immunobiology, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6791,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.68269374,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"60","issue":"8","first_page":"4757","last_page":"4763"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.04670000076293945,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11684","display_name":"Vibrio bacteria research studies","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vibrio-cholerae","display_name":"Vibrio cholerae","score":1.0},{"id":"https://openalex.org/keywords/outer-membrane-permeability","display_name":"outer membrane permeability","score":0.8100000023841858},{"id":"https://openalex.org/keywords/vancomycin-resistance","display_name":"vancomycin resistance","score":0.875},{"id":"https://openalex.org/keywords/bacitracin-resistance","display_name":"bacitracin resistance","score":0.9599999785423279},{"id":"https://openalex.org/keywords/glycopeptide-antibiotics","display_name":"glycopeptides","score":0.8169999718666077},{"id":"https://openalex.org/keywords/transposon-sequencing","display_name":"transposon sequencing","score":0.8450000286102295},{"id":"https://openalex.org/keywords/inner-membrane-proteins","display_name":"inner membrane proteins","score":0.8180000185966492},{"id":"https://openalex.org/keywords/biofilm-formation","display_name":"biofilm formation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2778643871","wikidata":"https://www.wikidata.org/wiki/Q160821","display_name":"Vibrio cholerae","level":3,"score":0.7783039808273315},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.715423583984375},{"id":"https://openalex.org/C2779860364","wikidata":"https://www.wikidata.org/wiki/Q61954719","display_name":"Bacitracin","level":3,"score":0.7003160715103149},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6409448981285095},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6387985348701477},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.5579574704170227},{"id":"https://openalex.org/C137610392","wikidata":"https://www.wikidata.org/wiki/Q2425020","display_name":"Glycopeptide","level":3,"score":0.5386345982551575},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.46071821451187134},{"id":"https://openalex.org/C4918238","wikidata":"https://www.wikidata.org/wiki/Q121438","display_name":"Transposable element","level":4,"score":0.4592769742012024},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.45293548703193665},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.44070619344711304},{"id":"https://openalex.org/C2776634448","wikidata":"https://www.wikidata.org/wiki/Q206920","display_name":"Peptidoglycan","level":3,"score":0.43398332595825195},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3014734983444214},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2663760781288147},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2375434935092926},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.20436453819274902},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.20403704047203064}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001414","descriptor_name":"Bacitracin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004251","descriptor_name":"DNA Transposable Elements","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006020","descriptor_name":"Glycopeptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014734","descriptor_name":"Vibrio cholerae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014734","descriptor_name":"Vibrio cholerae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.00576-16","doi":"https://doi.org/10.1128/aac.00576-16","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00576-16","pdf_url":"https://aac.asm.org/content/aac/60/8/4757.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmid:27216069","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27216069","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4958186","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4958186/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmh:oai:dash.harvard.edu:1/41483493","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:41483493","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/aac.00576-16","doi":"https://doi.org/10.1128/aac.00576-16","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aac.00576-16","pdf_url":"https://aac.asm.org/content/aac/60/8/4757.full.pdf","source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5628808026","display_name":"Molecular Biology and Virulence of CTX Phage","funder_award_id":"R37AI042347","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2404616178.pdf","grobid_xml":"https://content.openalex.org/works/W2404616178.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1568275547","https://openalex.org/W1579864754","https://openalex.org/W1931700765","https://openalex.org/W1969119600","https://openalex.org/W1971439989","https://openalex.org/W1975436949","https://openalex.org/W1981267913","https://openalex.org/W1984406957","https://openalex.org/W1986480819","https://openalex.org/W1998078173","https://openalex.org/W1998742798","https://openalex.org/W2001926579","https://openalex.org/W2010598074","https://openalex.org/W2015096214","https://openalex.org/W2030049548","https://openalex.org/W2043015302","https://openalex.org/W2044251513","https://openalex.org/W2063310269","https://openalex.org/W2075078623","https://openalex.org/W2084499784","https://openalex.org/W2087920996","https://openalex.org/W2091120384","https://openalex.org/W2095166719","https://openalex.org/W2102906662","https://openalex.org/W2108871577","https://openalex.org/W2111272687","https://openalex.org/W2117212584","https://openalex.org/W2120061656","https://openalex.org/W2122623487","https://openalex.org/W2134141380","https://openalex.org/W2151884314","https://openalex.org/W2151969594","https://openalex.org/W2165017841","https://openalex.org/W2220832120"],"related_works":["https://openalex.org/W4409619677","https://openalex.org/W7095168993","https://openalex.org/W4402026528","https://openalex.org/W4411976460","https://openalex.org/W2153336999","https://openalex.org/W2097705352","https://openalex.org/W4390381658","https://openalex.org/W4316015013","https://openalex.org/W7096703533","https://openalex.org/W2766082605"],"abstract_inverted_index":{"Gram-negative":[0,202],"bacteria":[1],"are":[2,58,77],"notoriously":[3],"resistant":[4],"to":[5,12,44,52,60,64,79,113,137,147,155,204],"a":[6,96,183],"variety":[7],"of":[8,16,23,177,189,201],"high-molecular-weight":[9],"antibiotics":[10,56,139,150,180],"due":[11],"the":[13,28,67,159,174,187,199,213],"limited":[14],"permeability":[15],"their":[17],"outer":[18,114],"membrane":[19,115,127],"(OM).":[20],"The":[21,69,117],"basis":[22],"OM":[24,85,190,214],"barrier":[25,86,215],"function":[26],"and":[27,54,88,129,141,143,206],"genetic":[29],"factors":[30],"required":[31,47],"for":[32,48,84,89,124],"its":[33,131],"maintenance":[34,188],"remain":[35],"incompletely":[36],"understood.":[37],"Here,":[38],"we":[39,94],"employed":[40],"transposon":[41],"insertion":[42],"sequencing":[43],"identify":[45],"genes":[46,73],"Vibrio":[49],"cholerae":[50],"resistance":[51],"vancomycin":[53,102],"bacitracin,":[55],"that":[57,105,170,212],"thought":[59],"be":[61],"too":[62],"large":[63,149,179],"efficiently":[65],"penetrate":[66],"OM.":[68],"screen":[70],"yielded":[71],"several":[72],"whose":[74],"protein":[75],"products":[76],"predicted":[78],"participate":[80],"in":[81,130,186,198],"processes":[82],"important":[83],"functions":[87],"biofilm":[90],"formation.":[91],"In":[92,153],"addition,":[93],"identified":[95],"novel":[97],"factor,":[98],"designated":[99],"vigA":[100,118,160],"(for":[101],"inhibits":[103],"growth),":[104],"has":[106],"not":[107,146,217],"previously":[108],"been":[109],"characterized":[110],"or":[111,151],"linked":[112],"function.":[116],"open":[119],"reading":[120],"frame":[121],"(ORF)":[122],"codes":[123],"an":[125],"inner":[126],"protein,":[128],"absence,":[132],"cells":[133],"became":[134],"highly":[135],"sensitive":[136],"glycopeptide":[138],"(vancomycin":[140],"ramoplanin)":[142],"bacitracin":[144],"but":[145,219],"other":[148],"detergents.":[152],"contrast":[154],"wild-type":[156],"(WT)":[157],"cells,":[158],"mutant":[161],"was":[162],"stained":[163],"with":[164],"fluorescent":[165],"vancomycin.":[166],"These":[167],"observations":[168],"suggest":[169,211],"VigA":[171],"specifically":[172],"prevents":[173],"periplasmic":[175],"accumulation":[176],"certain":[178],"without":[181],"exerting":[182],"general":[184],"role":[185],"integrity.":[191],"We":[192],"also":[193],"observed":[194],"marked":[195],"interspecies":[196],"variability":[197],"susceptibilities":[200],"pathogens":[203],"glycopeptides":[205],"bacitracin.":[207],"Collectively,":[208],"our":[209],"findings":[210],"is":[216],"absolute":[218],"rather":[220],"depends":[221],"on":[222],"specific":[223],"OM-antibiotic":[224],"interactions.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}