{"id":"https://openalex.org/W2404589543","doi":"https://doi.org/10.1128/jb.181.16.4755-4760.1999","title":"Regulation of Gene Expression by Glucose inSaccharomyces cerevisiae: a Role for ADA2and ADA3/NGG1","display_name":"Regulation of Gene Expression by Glucose inSaccharomyces cerevisiae: a Role for ADA2and ADA3/NGG1","publication_year":1999,"publication_date":"1999-08-15","ids":{"openalex":"https://openalex.org/W2404589543","doi":"https://doi.org/10.1128/jb.181.16.4755-4760.1999","mag":"2404589543","pmid":"https://pubmed.ncbi.nlm.nih.gov/10438741","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/93958"},"language":"en","primary_location":{"id":"doi:10.1128/jb.181.16.4755-4760.1999","doi":"https://doi.org/10.1128/jb.181.16.4755-4760.1999","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.181.16.4755-4760.1999","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/93958","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Mei Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mei Wu","raw_affiliation_strings":["Program in Cell and Molecular Biology,1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Cell and Molecular Biology,1","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064848608","display_name":"Laura L. Newcomb","orcid":"https://orcid.org/0000-0002-4380-8232","observed_orcids":["https://orcid.org/0000-0002-4380-8232"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Newcomb","raw_affiliation_strings":["Department of Biomolecular Chemistry,2 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Chemistry,2 and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011634304","display_name":"Warren Heideman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Warren Heideman","raw_affiliation_strings":["Department of Biomolecular Chemistry,2 and","School of Pharmacy,3 University of Wisconsin, Madison, Wisconsin 53706"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Chemistry,2 and","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy,3 University of Wisconsin, Madison, Wisconsin 53706","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3446,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.55760419,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"181","issue":"16","first_page":"4755","last_page":"4760"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose-regulation","display_name":"glucose regulation","score":0.5870000123977661},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7210000157356262},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9120000004768372},{"id":"https://openalex.org/keywords/adenosine-deaminase-2","display_name":"ADA2","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cln3","display_name":"CLN3","score":0.9100000262260437},{"id":"https://openalex.org/keywords/g1-cyclins","display_name":"G1 cyclins","score":0.9440000057220459},{"id":"https://openalex.org/keywords/transcriptional-induction","display_name":"transcriptional induction","score":0.6650000214576721},{"id":"https://openalex.org/keywords/cell-cycle-progression","display_name":"cell cycle progression","score":0.515999972820282},{"id":"https://openalex.org/keywords/rpd3","display_name":"Rpd3","score":0.7570000290870667},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":1.0},{"id":"https://openalex.org/keywords/mrna-down-regulation","display_name":"mRNA down-regulation","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9315147399902344},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6227940917015076},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6020876169204712},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.45805442333221436},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4527055621147156},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3900204002857208},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38939324021339417}],"mesh":[{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1128/jb.181.16.4755-4760.1999","doi":"https://doi.org/10.1128/jb.181.16.4755-4760.1999","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.181.16.4755-4760.1999","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:93958","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/93958","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},{"id":"pmid:10438741","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10438741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:93958","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/93958","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3490101761","display_name":null,"funder_award_id":"GM42406","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W144129310","https://openalex.org/W169216998","https://openalex.org/W1754004588","https://openalex.org/W1872853499","https://openalex.org/W1884388113","https://openalex.org/W1885706271","https://openalex.org/W1889276318","https://openalex.org/W1912625738","https://openalex.org/W1954246782","https://openalex.org/W1968112541","https://openalex.org/W1971842995","https://openalex.org/W1976075923","https://openalex.org/W1987527282","https://openalex.org/W1999952815","https://openalex.org/W2001994073","https://openalex.org/W2033749460","https://openalex.org/W2039832560","https://openalex.org/W2064607058","https://openalex.org/W2078906089","https://openalex.org/W2081036868","https://openalex.org/W2090509456","https://openalex.org/W2095669369","https://openalex.org/W2106257666","https://openalex.org/W2106900373","https://openalex.org/W2109054128","https://openalex.org/W2114491118","https://openalex.org/W2122297074","https://openalex.org/W2149732532","https://openalex.org/W2150503113","https://openalex.org/W2150681831","https://openalex.org/W2153942251","https://openalex.org/W2154264984","https://openalex.org/W2154348578","https://openalex.org/W2165011536","https://openalex.org/W2170778160","https://openalex.org/W2199878503","https://openalex.org/W4230772769","https://openalex.org/W4238836571","https://openalex.org/W4239029175","https://openalex.org/W4249097675","https://openalex.org/W4255667390","https://openalex.org/W4255697006"],"related_works":["https://openalex.org/W7096263338","https://openalex.org/W2153942251","https://openalex.org/W2121911008","https://openalex.org/W2008892277","https://openalex.org/W2150503113","https://openalex.org/W1976075923","https://openalex.org/W2159169567","https://openalex.org/W4244806051","https://openalex.org/W1763621819","https://openalex.org/W7098277878"],"abstract_inverted_index":{"When":[0],"Saccharomyces":[1],"cerevisiae":[2],"cells":[3],"are":[4,79,123,141],"transferred":[5],"from":[6],"poor":[7],"medium":[8,11],"to":[9,52,73,91,118,160],"fresh":[10],"containing":[12],"glucose,":[13],"they":[14,26],"rapidly":[15],"increase":[16,66,111],"the":[17,34,65,82,108,165,168,184,191],"transcription":[18,113],"of":[19,23,62,85,94,104,127,167,174,177,187,193],"a":[20,46,54,101,149,180],"large":[21,102],"group":[22],"genes":[24,39,105],"as":[25],"resume":[27],"rapid":[28,83,109,157],"growth":[29],"and":[30,77,106,125,129,153],"accelerate":[31],"progress":[32],"through":[33,59],"cell":[35],"cycle.":[36],"Among":[37],"those":[38],"induced":[40],"by":[41],"glucose":[42,74],"is":[43,50],"CLN3,":[44,175],"encoding":[45,179],"G(1)":[47],"cyclin":[48],"that":[49,114],"thought":[51],"play":[53],"pivotal":[55],"role":[56,150,166],"in":[57,67,71,89,112,116,143,155,171,190],"progression":[58],"Start.":[60],"Deletion":[61],"CLN3":[63,86,128,188],"delays":[64],"proliferation":[68],"normally":[69],"observed":[70],"response":[72,90,117],"medium.":[75],"ADA2":[76,96,136,152],"ADA3/NGG1":[78,98,138,154],"necessary":[80],"for":[81,151],"induction":[84],"message":[87],"levels":[88],"glucose.":[92,119,194],"Loss":[93],"either":[95],"or":[97,137],"also":[99],"affects":[100],"number":[103],"inhibits":[107],"global":[110],"occurs":[115],"Surprisingly,":[120],"these":[121],"effects":[122],"transitory,":[124],"expression":[126],"total":[130],"poly(A)(+)":[131],"RNA":[132],"appear":[133],"normal":[134],"when":[135],"deletion":[139,176],"mutants":[140],"examined":[142],"log-phase":[144],"growth.":[145],"These":[146],"results":[147],"indicate":[148],"allowing":[156],"transcriptional":[158],"responses":[159],"environmental":[161],"signals.":[162],"Consistent":[163],"with":[164],"Ada":[169],"proteins":[170],"positive":[172],"regulation":[173,186],"RPD3,":[178],"histone":[181],"deacetylase,":[182],"prevented":[183],"down":[185],"mRNA":[189],"absence":[192]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}