{"id":"https://openalex.org/W2404375994","doi":null,"title":"Mediation of multi-drug resistance in a Chinese hamster ovary cell line by a mutant type II topoisomerase.","display_name":"Mediation of multi-drug resistance in a Chinese hamster ovary cell line by a mutant type II topoisomerase.","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W2404375994","mag":"2404375994","pmid":"https://pubmed.ncbi.nlm.nih.gov/2819738"},"language":"en","primary_location":{"id":"pmid:2819738","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2819738","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NCI monographs : a publication of the National Cancer Institute","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110967559","display_name":"Bonnie S. Glisson","orcid":"https://orcid.org/0009-0006-7320-2940","observed_orcids":["https://orcid.org/0009-0006-7320-2940"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B S Glisson","raw_affiliation_strings":["Thoracic Head & Neck Medical Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Head & Neck Medical Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102841436","display_name":"Daniel M. Sullivan","orcid":"https://orcid.org/0009-0003-0951-9781","observed_orcids":["https://orcid.org/0009-0003-0951-9781","https://orcid.org/0000-0002-2183-1773"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D M Sullivan","raw_affiliation_strings":["University of Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R Gupta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Gupta","raw_affiliation_strings":["University of Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111473394","display_name":"Warren E. Ross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W E Ross","raw_affiliation_strings":["University of Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8264,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.73024946,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":"4","first_page":"89","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topoisomerase-ii","display_name":"topoisomerase II","score":0.8679999709129333},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.7889999747276306},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.7519999742507935},{"id":"https://openalex.org/keywords/epipodophyllotoxins","display_name":"epipodophyllotoxins","score":0.9620000123977661},{"id":"https://openalex.org/keywords/dna-intercalators","display_name":"DNA intercalators","score":0.9049999713897705},{"id":"https://openalex.org/keywords/dna-cleavage-activity","display_name":"DNA cleavage activity","score":0.6959999799728394},{"id":"https://openalex.org/keywords/cho-cells","display_name":"CHO cells","score":0.8149999976158142},{"id":"https://openalex.org/keywords/drug-resistance-mechanisms","display_name":"drug resistance mechanisms","score":0.4749999940395355},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.7833704948425293},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.7788338661193848},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.7285674810409546},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5750681757926941},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5595272183418274},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.5505587458610535},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.535396158695221},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5051398873329163},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4640248417854309},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4619022309780121},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4487145245075226},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.41853466629981995},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3777807354927063},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3743239939212799},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3695005774497986},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3567901849746704},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34607452154159546},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.270853191614151},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2198619842529297},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13833710551261902},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000677","descriptor_name":"Amsacrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000677","descriptor_name":"Amsacrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003630","descriptor_name":"Daunorubicin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003630","descriptor_name":"Daunorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004250","descriptor_name":"DNA Topoisomerases, Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004250","descriptor_name":"DNA Topoisomerases, Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2819738","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2819738","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NCI monographs : a publication of the National Cancer Institute","raw_type":"Journal Article"},{"id":"mag:2404375994","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2819738","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1854896859","https://openalex.org/W1625390868","https://openalex.org/W2012754297","https://openalex.org/W1586201322","https://openalex.org/W2418723040","https://openalex.org/W2135376066","https://openalex.org/W2042367294","https://openalex.org/W2473273130","https://openalex.org/W1979773981","https://openalex.org/W7096501668"],"abstract_inverted_index":{"Identification":[0],"of":[1,14,28,72,101,112],"DNA":[2,11,98],"topoisomerase":[3],"II":[4],"as":[5,68,103,105,123],"the":[6,10,15,56,82,95,181,190],"intracellular":[7],"target":[8],"for":[9,197],"cleavage":[12,66,99,150],"activity":[13,67,100,131,139,151],"epipodophyllotoxins":[16],"and":[17,97,127],"several":[18],"intercalating":[19,107],"agents":[20],"is":[21,58,119,136,140,158],"well":[22,104],"established.":[23],"In":[24,148],"contrast,":[25,149],"definite":[26],"correlation":[27],"cleavable":[29,198],"complex":[30,199],"formation":[31,200],"with":[32,44,187],"eventual":[33],"cell":[34,48,87,117,202],"death":[35],"has":[36],"been":[37],"more":[38],"difficult":[39],"to":[40,77,93,144,161],"document.":[41],"Our":[42],"studies":[43],"an":[45],"epipodophyllotoxin":[46],"resistant":[47,160,171],"line":[49],"not":[50],"only":[51],"provide":[52],"additional":[53],"evidence":[54],"that":[55,168,183],"enzyme":[57,154,182],"a":[59,69,169,177,194],"multi-drug":[60,170],"target,":[61],"but":[62],"also":[63,141],"implicate":[64],"drug-stimulated":[65],"critical":[70],"component":[71],"cytotoxic":[73,96],"effect.":[74],"When":[75],"compared":[76],"WT":[78],"(wild":[79],"type)":[80],"cells,":[81],"mutant":[83],"Chinese":[84],"hamster":[85],"ovary":[86],"line,":[88],"VpmR-5,":[89],"exhibits":[90],"marked":[91],"resistance":[92],"both":[94,116],"etoposide":[102],"various":[106],"agents.":[108],"Steady":[109],"state":[110],"concentrations":[111],"these":[113],"drugs":[114],"in":[115,132,152,180,201],"lines":[118],"identical.":[120],"Enzyme":[121],"content":[122],"measured":[124],"by":[125,128,146,163,176],"immunoblot":[126],"total":[129],"decatenation":[130],"crude":[133],"nuclear":[134],"extracts":[135],"equal.":[137],"Catalytic":[138],"equally":[142],"sensitive":[143],"inhibition":[145],"etoposide.":[147],"purified":[153],"from":[155],"VpmR-5":[156],"cells":[157],"profoundly":[159],"stimulation":[162],"drug.":[164,188],"These":[165],"data":[166,191],"indicate":[167],"phenotype":[172],"may":[173],"be":[174],"acquired":[175],"qualitative":[178],"change":[179],"alters":[184],"its":[185],"interaction":[186],"Further,":[189],"strongly":[192],"support":[193],"direct":[195],"role":[196],"death.":[203]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}