{"id":"https://openalex.org/W2404255666","doi":null,"title":"The rs5743708 gene polymorphism in the TLR2 gene contributes to the risk of tuberculosis disease.","display_name":"The rs5743708 gene polymorphism in the TLR2 gene contributes to the risk of tuberculosis disease.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2404255666","mag":"2404255666","pmid":"https://pubmed.ncbi.nlm.nih.gov/26617949","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4637765"},"language":"en","primary_location":{"id":"pmid:26617949","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26617949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4637765/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067158080","display_name":"Xu\u2010Guang Guo","orcid":"https://orcid.org/0000-0003-1302-5234","observed_orcids":["https://orcid.org/0000-0003-1302-5234"]},"institutions":[{"id":"https://openalex.org/I4210092091","display_name":"Third Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00fb35g87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092091"]},{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu-Guang Guo","raw_affiliation_strings":["Department of Clinical Laboratory Medicine, The Third affiliated Hospital of Guangzhou Medical University Guangzhou 510150, Guangdong, People's Republic of China ; Department of Internal Medicine, The Third Clinical College of Guangzhou Medical University Guangzhou 510150, Guangdong, People's Republic of China ; Department of Clinical Laboratory Medicine, Nanfang Hospital of Southern Medical University Guangzhou 510515, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Medicine, The Third affiliated Hospital of Guangzhou Medical University Guangzhou 510150, Guangdong, People's Republic of China ; Department of Internal Medicine, The Third Clinical College of Guangzhou Medical University Guangzhou 510150, Guangdong, People's Republic of China ; Department of Clinical Laboratory Medicine, Nanfang Hospital of Southern Medical University Guangzhou 510515, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210092091","https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051065216","display_name":"Yong Xia","orcid":"https://orcid.org/0000-0002-8611-6455","observed_orcids":["https://orcid.org/0000-0002-8611-6455"]},"institutions":[{"id":"https://openalex.org/I4210092091","display_name":"Third Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00fb35g87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092091"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Xia","raw_affiliation_strings":["Department of Clinical Laboratory Medicine, The Third affiliated Hospital of Guangzhou Medical University Guangzhou 510150, Guangdong, People's Republic of China ; Department of Internal Medicine, The Third Clinical College of Guangzhou Medical University Guangzhou 510150, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Medicine, The Third affiliated Hospital of Guangzhou Medical University Guangzhou 510150, Guangdong, People's Republic of China ; Department of Internal Medicine, The Third Clinical College of Guangzhou Medical University Guangzhou 510150, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210092091"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4788,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.80365577,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"9","first_page":"11921","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr2-gene","display_name":"TLR2 gene","score":0.9150000214576721},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9330000281333923},{"id":"https://openalex.org/keywords/tuberculosis-susceptibility","display_name":"tuberculosis susceptibility","score":0.9480000138282776},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.796999990940094},{"id":"https://openalex.org/keywords/rs2910164","display_name":"rs2910164","score":0.8700000047683716},{"id":"https://openalex.org/keywords/ethnic-differences-in-genetic-risk","display_name":"ethnic differences in genetic risk","score":0.6050000190734863},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.6389999985694885},{"id":"https://openalex.org/keywords/tuberculosis-prevention","display_name":"tuberculosis prevention","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6676546335220337},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6270800828933716},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6136149168014526},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.5974303483963013},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49141132831573486},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47937825322151184},{"id":"https://openalex.org/C76252995","wikidata":"https://www.wikidata.org/wiki/Q3395645","display_name":"Gene polymorphism","level":4,"score":0.47815975546836853},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.46664145588874817},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44828546047210693},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.43372732400894165},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3919815421104431},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33466655015945435},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.282054603099823},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12390810251235962}],"mesh":[{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044469","descriptor_name":"Racial Groups","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:26617949","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26617949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4637765","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4637765/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"mag:2404255666","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26617949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4637765","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4637765/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W78649709","https://openalex.org/W1965398283","https://openalex.org/W1967685939","https://openalex.org/W2023775676","https://openalex.org/W2038884188","https://openalex.org/W2060989275","https://openalex.org/W2075064513","https://openalex.org/W2076038783","https://openalex.org/W2076886077","https://openalex.org/W2091714910","https://openalex.org/W2109152623","https://openalex.org/W2125099402","https://openalex.org/W2132427034","https://openalex.org/W2135230337","https://openalex.org/W2138822121","https://openalex.org/W2146469910","https://openalex.org/W2157823046","https://openalex.org/W4297791620"],"related_works":["https://openalex.org/W4387925029","https://openalex.org/W2333583617","https://openalex.org/W2510813708","https://openalex.org/W2962694050","https://openalex.org/W4211228105","https://openalex.org/W2211143398","https://openalex.org/W2072890032","https://openalex.org/W7141629561","https://openalex.org/W7096391455","https://openalex.org/W4404542733"],"abstract_inverted_index":{"BACKGROUND:":[0],"It":[1],"has":[2],"been":[3],"reported":[4],"that":[5],"one":[6],"single":[7],"nucleotide":[8],"polymorphisms":[9],"(SNPs)":[10],"rs5743708":[11,43,67,116,136,217,234],"in":[12,46,70,81,119,139,148,220,237],"TLR2":[13,48,72,121,141,222,239],"gene":[14,44,49,68,73,117,122,137,142,218,223,235,240],"might":[15],"be":[16],"associated":[17],"with":[18,74,232],"the":[19,39,42,47,51,63,66,71,96,115,120,124,135,140,208,212,221,226,233,238],"susceptibility":[20,75],"to":[21,25,34,76,94,225],"tuberculosis":[22,54,77,127,144,229,247],"disease.":[23,55,230,248],"Owing":[24],"mixed":[26],"and":[27,37,50,86,111,123,143,187,211],"inconclusive":[28],"results,":[29],"we":[30],"conducted":[31,80],"a":[32,159,168,177,188,243],"meta-analysis":[33],"systematically":[35],"summarize":[36],"clarify":[38],"association":[40,64],"between":[41,134,207],"polymorphism":[45,69,118,138,219,236],"risk":[52,125,227,245],"of":[53,60,65,102,126,228],"METHODS:":[56],"A":[57,100,131],"systematic":[58],"search":[59],"studies":[61,105,113],"on":[62,109,114,202],"disease":[78,128,145],"was":[79,146,205],"PubMed.":[82],"Odds":[83],"ratios":[84],"(ORs)":[85],"95%":[87,155,164,173,183,194],"confidence":[88],"intervals":[89],"(95%":[90],"CIs)":[91],"were":[92,129],"used":[93],"pool":[95],"effect":[97],"size.":[98],"RESULTS:":[99],"total":[101],"nineteen":[103],"case-control":[104],"from":[106],"13":[107],"articles":[108],"rs2910164":[110],"3":[112],"included.":[130],"significant":[132],"relationship":[133],"discovered":[147],"an":[149],"allelic":[150],"genetic":[151,179,190],"model":[152,161,170,180,191],"(OR:":[153,162,171,181],"2.801,":[154],"CI:":[156,165,174,184,195],"2.130-3.683,":[157],"P=0.000),":[158,176],"homozygote":[160],"5.795,":[163],"1.982-16.941,":[166],"P=0.001),":[167],"heterozygote":[169],"2.628,":[172],"1.888-3.569,":[175],"dominant":[178],"2.786,":[182],"2.003-3.877,":[185],"P=0.000)":[186],"recessive":[189],"OR:":[192],"(5.568,":[193],"1.907-16.255,":[196],"P=0.002).":[197],"In":[198],"sub-group":[199],"analysis":[200],"base":[201],"ethnicity,":[203],"significance":[204],"observed":[206],"Caucasian":[209],"group":[210],"Asian":[213],"group.":[214],"CONCLUSIONS:":[215],"The":[216],"contributes":[224],"Individuals":[231],"are":[241],"under":[242],"higher":[244],"for":[246]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}