{"id":"https://openalex.org/W2404149307","doi":null,"title":"Oncogenes, tumour suppressor genes and growth factors in breast cancer: novel targets for diagnosis, prognosis and therapy.","display_name":"Oncogenes, tumour suppressor genes and growth factors in breast cancer: novel targets for diagnosis, prognosis and therapy.","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W2404149307","mag":"2404149307","pmid":"https://pubmed.ncbi.nlm.nih.gov/8012999"},"language":"en","primary_location":{"id":"pmid:8012999","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8012999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer surveys","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111490657","display_name":"Robert Callahan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Callahan","raw_affiliation_strings":["Oncogenetics Section, National Cancer Institute, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncogenetics Section, National Cancer Institute, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083948150","display_name":"Salomon Ds","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D S Salomon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0009,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.76191295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":null,"first_page":"35","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.6547999978065491,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.6547999978065491,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.20149999856948853,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.07450000196695328,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9900000095367432},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.9580000042915344},{"id":"https://openalex.org/keywords/growth-factor-receptors","display_name":"growth factor receptors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.921999990940094},{"id":"https://openalex.org/keywords/abnormal-gene-expression","display_name":"aberrant gene expression","score":0.7419999837875366},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.6620000004768372},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.902999997138977},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8880000114440918},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6572595834732056},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.6070518493652344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.510826826095581},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4932398200035095},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.470167338848114},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4569040834903717},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44723206758499146},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42437100410461426},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.42282813787460327},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3765246272087097},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32026880979537964},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2440083622932434},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8012999","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8012999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer surveys","raw_type":"Journal Article"},{"id":"mag:2404149307","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8012999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2115321397","https://openalex.org/W2413603736","https://openalex.org/W261966619","https://openalex.org/W2010892549","https://openalex.org/W2944343400","https://openalex.org/W2138324119","https://openalex.org/W1990748433","https://openalex.org/W2113720176","https://openalex.org/W588261757","https://openalex.org/W2910525070"],"abstract_inverted_index":{"The":[0],"complexity":[1],"of":[2,27,73,87,97,140,172,191,201,226],"growth":[3,6],"factors":[4],"and":[5,29,71,95,113,117,164,177,222],"factor":[7],"receptors":[8],"that":[9,19,53,76,100,166,182,198,232],"are":[10,77,101,136,205,212],"aberrantly":[11,58,102],"expressed,":[12],"as":[13,15,108,110,215],"well":[14,109],"the":[16,25,36,55,69,83,127,138,170,189,192,195,218],"mutational":[17],"events":[18],"either":[20],"directly":[21],"cause":[22],"or":[23,43],"influence":[24],"expression":[26],"these":[28,202],"other":[30],"gene":[31,60,149,203],"products,":[32],"should":[33,125],"provide":[34],"in":[35,62,104,175,178,194,207,235],"near":[37],"future":[38],"multiple":[39],"diagnostic,":[40],"prognostic":[41],"indicators":[42],"targets":[44,131],"for":[45,57,132],"therapeutic":[46,133],"intervention.":[47,134],"It":[48],"seems":[49],"reasonable":[50],"to":[51,115,129,159],"expect":[52],"soon":[54],"search":[56,70],"expressed":[59,103],"products":[61,150,204],"breast":[63,105,229],"cancer":[64,230],"cells":[65],"will":[66,157,183],"merge":[67],"with":[68],"characterization":[72],"somatic":[74],"mutations":[75],"selected":[78],"during":[79],"tumour":[80,106],"progression.":[81],"Clearly,":[82],"current":[84],"rapid":[85],"development":[86],"new":[88],"molecular":[89,111],"biological":[90],"methodologies":[91],"aimed":[92],"at":[93,137],"detecting":[94],"cloning":[96],"RNA":[98],"sequences":[99],"cells,":[107],"probes":[112],"reagents":[114,165],"detect":[116],"physically":[118],"map":[119],"mutated":[120,219],"genes":[121],"on":[122,169,188],"affected":[123],"chromosomes,":[124],"accelerate":[126],"effort":[128],"identify":[130],"We":[135],"beginning":[139],"this":[141,236],"learning":[142],"curve,":[143],"but":[144],"already":[145],"several":[146],"potential":[147],"target":[148,199],"have":[151,185],"been":[152],"identified.":[153],"A":[154],"major":[155],"challenge":[156],"be":[158],"sort":[160],"out":[161],"those":[162],"approaches":[163],"appear":[167],"efficacious":[168],"basis":[171],"results":[173],"from":[174],"vitro":[176],"vivo":[179],"model":[180],"systems":[181],"actually":[184],"an":[186],"impact":[187],"treatment":[190,225],"disease":[193],"clinic.":[196],"Reagents":[197],"some":[200],"currently":[206],"clinical":[208],"trials;":[209],"however,":[210],"there":[211],"others":[213],"such":[214],"immunotherapy":[216],"against":[217],"TP53":[220],"protein":[221],"human":[223],"CG":[224],"high":[227],"risk":[228],"patients":[231],"warrant":[233],"testing":[234],"context.":[237]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}