{"id":"https://openalex.org/W2404081591","doi":null,"title":"Activation of the contact system of plasma proteolysis in the adult respiratory distress syndrome.","display_name":"Activation of the contact system of plasma proteolysis in the adult respiratory distress syndrome.","publication_year":1988,"publication_date":"1988-08-01","ids":{"openalex":"https://openalex.org/W2404081591","mag":"2404081591","pmid":"https://pubmed.ncbi.nlm.nih.gov/3397629"},"language":"en","primary_location":{"id":"pmid:3397629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3397629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110397470","display_name":"Angelina C. A. Carvalho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I2802759389","display_name":"Providence VA Medical Center","ror":"https://ror.org/041m0cc93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2802759389","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A C Carvalho","raw_affiliation_strings":["Section of Hematology, Veterans Administration Medical Center, Providence, Rhode Island"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Hematology, Veterans Administration Medical Center, Providence, Rhode Island","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I2802759389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002499586","display_name":"Sandra M. DeMarinis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S DeMarinis","raw_affiliation_strings":["Temple University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple University","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109438465","display_name":"Cheryl F. Scott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C F Scott","raw_affiliation_strings":["Temple University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple University","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003868834","display_name":"Lee D. Silver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L D Silver","raw_affiliation_strings":["Temple University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple University","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066630966","display_name":"Alvin H. Schmaier","orcid":"https://orcid.org/0000-0002-3884-6234","observed_orcids":["https://orcid.org/0000-0002-3884-6234"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A H Schmaier","raw_affiliation_strings":["Temple University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple University","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104652394","display_name":"Robert W. Colman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R W Colman","raw_affiliation_strings":["Temple University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Temple University","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.267,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.96242014,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"112","issue":"2","first_page":"270","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.9700000286102295},{"id":"https://openalex.org/keywords/contact-system","display_name":"contact system","score":0.796999990940094},{"id":"https://openalex.org/keywords/plasma-proteolysis","display_name":"plasma proteolysis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/factor-xii","display_name":"factor XII","score":0.9240000247955322},{"id":"https://openalex.org/keywords/prekallikrein","display_name":"prekallikrein","score":0.9829999804496765},{"id":"https://openalex.org/keywords/high-molecular-weight-kininogen","display_name":"high molecular weight kininogen","score":0.9990000128746033},{"id":"https://openalex.org/keywords/c1-inhibitor","display_name":"C1 inhibitor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.7419999837875366},{"id":"https://openalex.org/keywords/trauma-physical-injury","display_name":"trauma (physical injury)","score":0.7360000014305115},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.8320000171661377},{"id":"https://openalex.org/keywords/intravascular-coagulation","display_name":"intravascular coagulation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/endothelial-injury","display_name":"endothelial injury","score":0.7789999842643738},{"id":"https://openalex.org/keywords/antithrombin-iii","display_name":"antithrombin III","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.9399776458740234},{"id":"https://openalex.org/C2781317560","wikidata":"https://www.wikidata.org/wiki/Q24721273","display_name":"High-molecular-weight kininogen","level":5,"score":0.863339900970459},{"id":"https://openalex.org/C152328610","wikidata":"https://www.wikidata.org/wiki/Q7240014","display_name":"Prekallikrein","level":4,"score":0.8187397718429565},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.7698112726211548},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6217607259750366},{"id":"https://openalex.org/C2777167447","wikidata":"https://www.wikidata.org/wiki/Q339499","display_name":"Factor XII","level":3,"score":0.5597020983695984},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.551153838634491},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.5507784485816956},{"id":"https://openalex.org/C2778734968","wikidata":"https://www.wikidata.org/wiki/Q823027","display_name":"Disseminated intravascular coagulation","level":2,"score":0.4958253800868988},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4696311950683594},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.44490790367126465},{"id":"https://openalex.org/C2779026020","wikidata":"https://www.wikidata.org/wiki/Q416336","display_name":"Antithrombin","level":3,"score":0.43504321575164795},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.433102011680603},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.328088641166687},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3171321153640747},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.258412629365921},{"id":"https://openalex.org/C2777902427","wikidata":"https://www.wikidata.org/wiki/Q6413860","display_name":"Kininogen","level":4,"score":0.19187304377555847},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18168649077415466},{"id":"https://openalex.org/C52853521","wikidata":"https://www.wikidata.org/wiki/Q423285","display_name":"Kallikrein","level":3,"score":0.18116316199302673},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.11234068870544434},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10877025127410889},{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001779","descriptor_name":"Blood Coagulation Factors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003174","descriptor_name":"Complement C1 Inactivator Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005172","descriptor_name":"Factor XI","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005174","descriptor_name":"Factor XII","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005342","descriptor_name":"Fibrinolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007610","descriptor_name":"Kallikreins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007704","descriptor_name":"Kininogens","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010314","descriptor_name":"Partial Thromboplastin Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010976","descriptor_name":"Platelet Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011288","descriptor_name":"Prekallikrein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011517","descriptor_name":"Prothrombin Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:3397629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3397629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Comparative Study"},{"id":"mag:2404081591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3397629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2776469374","https://openalex.org/W2589973122","https://openalex.org/W2414271850","https://openalex.org/W102892713","https://openalex.org/W2133310011","https://openalex.org/W2434633141","https://openalex.org/W2411927811","https://openalex.org/W2002520091","https://openalex.org/W2021773314","https://openalex.org/W2398192087"],"abstract_inverted_index":{"Adult":[0],"respiratory":[1],"distress":[2],"syndrome":[3],"(ARDS)":[4],"is":[5],"a":[6],"complex":[7],"pulmonary":[8,13],"clinicopathologic":[9],"condition":[10],"associated":[11],"with":[12,22,34,50,111,145,225],"endothelial":[14,212],"injury":[15,213],"and":[16,45,70,74,100,140,151,199,221],"blood":[17],"coagulation":[18,44,198,220],"activation.":[19,235],"In":[20,147],"patients":[21,49,224],"ARDS":[23,35,52,112,153,186,226],"from":[24,169,229,232],"all":[25],"causes,":[26],"factor":[27,129],"VII":[28],"levels":[29,143,165],"were":[30,103,166,181,188],"significantly":[31,55,120,159,167],"reduced.":[32],"Patients":[33,110],"caused":[36,113],"by":[37,53,114],"sepsis":[38,118],"had":[39,119],"more":[40,182],"evidence":[41],"of":[42,86,90,177,202,211,217],"intravascular":[43,197],"fibrinolysis":[46,222],"than":[47,58,123,187],"did":[48],"trauma-related":[51,152],"having":[54],"(p":[56,121],"less":[57,122],"or":[59,117,124],"equal":[60,125],"to":[61,81,126,193],"0.05)":[62],"increased":[63],"prothrombin":[64],"times,":[65,69],"activated":[66,105,184],"partial":[67],"thromboplastin":[68],"fibrin":[71],"degradation":[72],"products,":[73],"decreased":[75],"antithrombin":[76],"III":[77],"concentration.":[78],"We":[79],"sought":[80],"determine":[82],"whether":[83],"the":[84,87,149,175,178,189,203,209],"proteins":[85,176,190,206],"contact":[88,179,204,233],"system":[89,180,205,234],"plasma":[91],"proteolysis":[92],"(factor":[93],"XII,":[94],"prekallikrein,":[95],"high":[96,132],"molecular":[97,133],"weight":[98,134],"kininogen,":[99],"C1":[101,155,162],"inhibitor)":[102],"also":[104,227],"after":[106],"acute":[107],"lung":[108],"injury.":[109],"either":[115],"trauma":[116],"0.01)":[127],"reduced":[128,160],"XII":[130],"levels,":[131],"kininogen":[135],"functional":[136],"activity,":[137,139],"prekallikrein":[138,141],"antigen":[142,164],"compared":[144],"controls.":[146],"both":[148],"sepsis-related":[150],"groups,":[154],"inhibitor":[156,163],"activity":[157],"was":[158],"but":[161],"elevated":[168],"control.":[170],"These":[171],"findings":[172],"showed":[173],"that":[174,191],"extensively":[183],"in":[185,196,223],"contribute":[192],"later":[194],"reactions":[195],"fibrinolysis.":[200],"Activation":[201],"could":[207],"be":[208],"result":[210],"occurring":[214],"as":[215],"part":[216],"ARDS.":[218],"Intravascular":[219],"arise":[228],"components":[230],"independent":[231]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}