{"id":"https://openalex.org/W2404076246","doi":null,"title":"Cardiovascular deconditioning through head-down tilt bed rest increases blood pressure variability and plasma renin activity.","display_name":"Cardiovascular deconditioning through head-down tilt bed rest increases blood pressure variability and plasma renin activity.","publication_year":1996,"publication_date":"1996-06-01","ids":{"openalex":"https://openalex.org/W2404076246","mag":"2404076246","pmid":"https://pubmed.ncbi.nlm.nih.gov/8827135"},"language":"en","primary_location":{"id":"pmid:8827135","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8827135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aviation, space, and environmental medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J F Schmedtje","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J F Schmedtje","raw_affiliation_strings":["Department of Internal Medicine, Medical College of Virginia, Richmond, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Medical College of Virginia, Richmond, USA","institution_ids":["https://openalex.org/I72019824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070456546","display_name":"Liu Wl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W L Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5016061416","display_name":"Addison A. Taylor","orcid":"https://orcid.org/0000-0003-3788-3137","observed_orcids":["https://orcid.org/0000-0003-3788-3137"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A A Taylor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6697,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.64257504,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":94},"biblio":{"volume":"67","issue":"6","first_page":"539","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.03579999879002571,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11950","display_name":"Cardiovascular Syncope and Autonomic Disorders","score":0.021800000220537186,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiovascular-deconditioning","display_name":"cardiovascular deconditioning","score":0.9649999737739563},{"id":"https://openalex.org/keywords/head-down-bed-rest","display_name":"head-down bed rest","score":0.9079999923706055},{"id":"https://openalex.org/keywords/blood-pressure-variability","display_name":"blood pressure variability","score":0.9279999732971191},{"id":"https://openalex.org/keywords/plasma-renin-activity","display_name":"plasma renin activity","score":0.9940000176429749},{"id":"https://openalex.org/keywords/renin-angiotensin-aldosterone-system","display_name":"renin-angiotensin-aldosterone system","score":0.9819999933242798},{"id":"https://openalex.org/keywords/lower-body-negative-pressure","display_name":"lower body negative pressure","score":0.8289999961853027},{"id":"https://openalex.org/keywords/orthostatic-stress","display_name":"orthostatic stress","score":0.984000027179718},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9129999876022339},{"id":"https://openalex.org/keywords/adrenergic-tone","display_name":"adrenergic tone","score":0.9549999833106995},{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":0.4410000145435333},{"id":"https://openalex.org/keywords/sodium-excretion","display_name":"sodium excretion","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C2777152909","wikidata":"https://www.wikidata.org/wiki/Q5249582","display_name":"Deconditioning","level":2,"score":0.7932491302490234},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.786253809928894},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7797802686691284},{"id":"https://openalex.org/C2910053146","wikidata":"https://www.wikidata.org/wiki/Q1742390","display_name":"Head-Down Tilt","level":3,"score":0.6727526187896729},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.5924409627914429},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.5652185678482056},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5514390468597412},{"id":"https://openalex.org/C2777854218","wikidata":"https://www.wikidata.org/wiki/Q850197","display_name":"Bed rest","level":2,"score":0.5456683039665222},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5435885787010193},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.4728047251701355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43454450368881226},{"id":"https://openalex.org/C37557685","wikidata":"https://www.wikidata.org/wiki/Q1896673","display_name":"Blood volume","level":2,"score":0.43251535296440125},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.33415430784225464}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001510","descriptor_name":"Bed Rest","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004837","descriptor_name":"Epinephrine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010953","descriptor_name":"Plasma Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012084","descriptor_name":"Renin-Angiotensin System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017704","descriptor_name":"Baroreflex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018475","descriptor_name":"Head-Down Tilt","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018493","descriptor_name":"Cardiovascular Deconditioning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8827135","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8827135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aviation, space, and environmental medicine","raw_type":"Journal Article"},{"id":"mag:2404076246","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8827135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5966678231","display_name":"General Clinical Research Center","funder_award_id":"M01RR000065","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2412341596","https://openalex.org/W2255753700","https://openalex.org/W2436041663","https://openalex.org/W60824380","https://openalex.org/W4398210599","https://openalex.org/W2092604096","https://openalex.org/W4398252526","https://openalex.org/W4327510588","https://openalex.org/W2043108352","https://openalex.org/W2415964166"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"renin-angiotensin-aldosterone":[2,64],"system":[3,65,230],"may":[4],"be":[5],"of":[6,12,50,54,100,116,128,155],"primary":[7],"importance":[8],"in":[9,62,67,200,231],"the":[10,24,51,63,70,153,176,228],"mechanism":[11],"bed":[13,27,83],"rest":[14,28],"cardiovascular":[15,29,71,117,232],"deconditioning.":[16,233],"HYPOTHESIS:":[17],"This":[18],"study":[19],"was":[20,136,182,195],"designed":[21],"to":[22,46,147,180],"test":[23],"hypothesis":[25],"that":[26],"deconditioning":[30,72,118,194],"does":[31],"not":[32,170,188],"result":[33],"simply":[34],"from":[35],"plasma":[36,55,133,164,177],"volume":[37,56],"loss,":[38],"but":[39,161],"is":[40],"also":[41],"at":[42,143,152],"least":[43],"partially":[44],"attributable":[45],"a":[47,104,114,126,220],"persistent":[48],"disequilibrium":[49],"neuroendocrine":[52],"mediators":[53],"homeostasis.":[57],"We":[58],"examined":[59],"whether":[60],"changes":[61],"occur":[66],"association":[68],"with":[69,103,172,197],"and":[73,96,119,145,166,213,227],"hemodynamic":[74],"instability":[75],"induced":[76],"by":[77,208],"antiorthostatic":[78],"6":[79],"degrees":[80],"head-down":[81,101,111,156,173,191],"tilt":[82,102,112,157],"rest.":[84],"METHODS:":[85],"Normal":[86],"male":[87],"volunteers":[88],"(n":[89],"=":[90],"10)":[91],"were":[92],"tested":[93],"before,":[94],"during,":[95],"after":[97],"14":[98],"d":[99],"high":[105],"(150":[106],"mEq.d-1)":[107],"salt":[108],"intake,":[109],"using":[110],"as":[113,125,206],"model":[115,127],"lower":[120],"body":[121],"negative":[122],"pressure":[123,202,225],"(LBNP)":[124],"orthostatic":[129],"stress.":[130],"RESULTS:":[131],"Resting":[132],"renin":[134],"activity":[135],"2.22":[137],"+/-":[138,149],"0.85":[139],"ng.ml-1.h-1":[140,151],"(+/-":[141],"SD)":[142],"baseline":[144],"increased":[146],"4.14":[148],"1.21":[150],"end":[154],"(p":[158],"<":[159],"0.05),":[160],"urine":[162,167],"aldosterone,":[163,165],"sodium":[168],"did":[169,187],"change":[171,189],"tilt.":[174,192],"Although":[175],"norepinephrine":[178],"response":[179],"LBNP":[181,205],"accentuated,":[183],"resting":[184],"adrenergic":[185],"tone":[186],"during":[190,204],"Cardiovascular":[193],"associated":[196],"an":[198],"increase":[199],"blood":[201,224],"variability":[203,226],"assessed":[207],"both":[209],"beat-to-beat":[210],"standard":[211],"deviation":[212],"spectral":[214],"analysis.":[215],"CONCLUSIONS:":[216],"These":[217],"data":[218],"support":[219],"proposed":[221],"link":[222],"between":[223],"renin-angiotensin":[229]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}