{"id":"https://openalex.org/W2404069843","doi":null,"title":"Cytokines and heart rate variability in patients with chronic heart failure.","display_name":"Cytokines and heart rate variability in patients with chronic heart failure.","publication_year":2005,"publication_date":"2005-11-01","ids":{"openalex":"https://openalex.org/W2404069843","mag":"2404069843","pmid":"https://pubmed.ncbi.nlm.nih.gov/16362851"},"language":"en","primary_location":{"id":"pmid:16362851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16362851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kardiologia polska","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025724170","display_name":"Ewa Straburzy\u0144ska\u2010Migaj","orcid":"https://orcid.org/0000-0002-0545-3370","observed_orcids":["https://orcid.org/0000-0002-0545-3370"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Ewa Straburzy\u0144ska-Migaj","raw_affiliation_strings":["I Klinika Kardiologii, Katedra Kardiologii Akademii Medycznej, ul. D\u0142uga 1/2, 61-848 Pozna\u0144. ewa.migaj-straburzynska@sk1.am.poznan.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I Klinika Kardiologii, Katedra Kardiologii Akademii Medycznej, ul. D\u0142uga 1/2, 61-848 Pozna\u0144. ewa.migaj-straburzynska@sk1.am.poznan.pl","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091246076","display_name":"Romuald Ochotny","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Romuald Ochotny","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031286967","display_name":"Hanna Wachowiak\u00ad\u2010Baszy\u0144ska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Wachowiak-Baszy\u0144ska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024666536","display_name":"Anna Straburzy\u0144ska\u2010Lupa","orcid":"https://orcid.org/0000-0001-8779-623X","observed_orcids":["https://orcid.org/0000-0001-8779-623X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Straburzy\u0144ska-Lupa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068513948","display_name":"Kinga Le\u015bniewska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kinga Le\u015bniewska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023446547","display_name":"Krzysztof Wiktorowicz","orcid":"https://orcid.org/0000-0001-8711-1659","observed_orcids":["https://orcid.org/0000-0001-8711-1659"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krzysztof Wiktorowicz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084507199","display_name":"Andrzej Cie\u015bli\u0144ski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrzej Cie\u015bli\u0144ski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4325,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.7261445,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"63","issue":"5","first_page":"478","last_page":"85; discussion 486"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-heart-failure","display_name":"chronic heart failure","score":0.9150000214576721},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":1.0},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7829999923706055},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.953000009059906},{"id":"https://openalex.org/keywords/autonomic-nervous-system","display_name":"autonomic nervous system","score":0.847000002861023},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/time-domain-hrv","display_name":"time-domain HRV","score":0.6179999709129333},{"id":"https://openalex.org/keywords/sdnn","display_name":"SDNN","score":0.7049999833106995},{"id":"https://openalex.org/keywords/sdann","display_name":"SDANN","score":0.7300000190734863},{"id":"https://openalex.org/keywords/plasma-cytokine-levels","display_name":"plasma cytokines","score":0.7020000219345093},{"id":"https://openalex.org/keywords/disease-progression-biomarkers","display_name":"disease progression biomarkers","score":0.7639999985694885},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.6240000128746033},{"id":"https://openalex.org/keywords/neuroendocrine-dysfunction","display_name":"neuroendocrine dysfunction","score":0.36899998784065247}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8852474093437195},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6649086475372314},{"id":"https://openalex.org/C71635504","wikidata":"https://www.wikidata.org/wiki/Q933954","display_name":"Heart rate variability","level":4,"score":0.6319898366928101},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6267446279525757},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5661185383796692},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.21940132975578308},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047888","descriptor_name":"Receptors, Tumor Necrosis Factor, Type I","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D047889","descriptor_name":"Receptors, Tumor Necrosis Factor, Type II","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:16362851","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16362851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kardiologia polska","raw_type":"Clinical Trial"},{"id":"mag:2404069843","doi":null,"is_oa":false,"landing_page_url":"https://journals.viamedica.pl/kardiologia_polska/article/view/81751","pdf_url":null,"source":{"id":"https://openalex.org/S164277434","display_name":"Kardiologia Polska","issn_l":"0022-9032","issn":["0022-9032","1897-4279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320293","host_organization_name":"Via Medica","host_organization_lineage":["https://openalex.org/P4310320293"],"host_organization_lineage_names":["Via Medica"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Kardiologia Polska","raw_type":null},{"id":"mag:2993670485","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16362851","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1966294459","https://openalex.org/W1976986448","https://openalex.org/W1980468558","https://openalex.org/W1984235771","https://openalex.org/W1984701352","https://openalex.org/W1988160820","https://openalex.org/W2010363665","https://openalex.org/W2037674743","https://openalex.org/W2054051454","https://openalex.org/W2056463863","https://openalex.org/W2093912976","https://openalex.org/W2106990917","https://openalex.org/W2107530490","https://openalex.org/W2121199588","https://openalex.org/W2132477982","https://openalex.org/W2133589238","https://openalex.org/W2185360329","https://openalex.org/W2404273444"],"related_works":["https://openalex.org/W2993670485","https://openalex.org/W1988160820","https://openalex.org/W2385053912","https://openalex.org/W2000890631","https://openalex.org/W139763003","https://openalex.org/W2394141469","https://openalex.org/W1643779001","https://openalex.org/W2374315802","https://openalex.org/W3029049537","https://openalex.org/W3030051363"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Heart":[1],"rate":[2],"variability":[3],"(HRV)":[4],"analysis":[5,140,183],"is":[6,36],"a":[7],"non-invasive":[8],"method":[9],"of":[10,12,32,44,75,99,107,115,145,152,190,300,319,327],"assessment":[11],"the":[13,30,33,56,61,73,100,105,113,136,182,188,196,200,206,210,295,298,308,317,325],"autonomic":[14],"nervous":[15,57],"system's":[16],"effects":[17],"on":[18,144],"heart":[19,23],"function.":[20],"In":[21,174,199],"chronic":[22],"failure":[24],"(CHF),":[25],"decreased":[26],"HRV":[27,70,92,139,178,223,290,320],"correlates":[28],"with":[29,121,176,195],"progression":[31],"disease.":[34],"It":[35],"also":[37],"known":[38],"that":[39],"in":[40,69,72,94,109,135,181,193,205,294,322,329],"CHF":[41,76,95,122,207,323],"increased":[42,192],"levels":[43,189,287],"proinflammatory":[45],"cytokines":[46,90,191,328],"are":[47,52,313],"present.":[48],"Because":[49,297],"these":[50],"molecules":[51],"believed":[53],"to":[54,85,315],"influence":[55],"system":[58],"at":[59],"both":[60,204],"central":[62],"and":[63,91,112,123,129,157,159,187,209,221,233,247,254,264,271,285,288,324],"peripheral":[64],"levels,":[65],"their":[66],"potential":[67,87],"role":[68,326],"reduction":[71],"course":[74],"has":[77],"been":[78],"proposed.":[79],"AIM:":[80],"The":[81,97],"study":[82,101,202],"was":[83,102,141],"designed":[84],"verify":[86],"relations":[88],"between":[89,218,244,261,279],"parameters":[93,291],"patients.":[96],"concept":[98],"driven":[103],"by":[104],"recognition":[106],"controversies":[108],"this":[110,330],"field":[111],"paucity":[114],"published":[116],"reports.":[117],"METHODS:":[118],"Forty-four":[119],"patients":[120,175,208],"stable":[124],"NYHA":[125],"class":[126],"I-IV":[127],"symptoms":[128],"15":[130],"healthy":[131],"controls":[132],"were":[133,163,184,216,242,292],"enrolled":[134],"study.":[137,296],"Time-domain":[138],"performed":[142],"based":[143],"24-hour":[146],"Holter":[147],"ECG":[148],"monitoring.":[149],"Plasma":[150],"concentrations":[151],"soluble":[153,281],"TNFalpha":[154],"receptors":[155,282],"sTNF-RI":[156,219],"sTNF-RII":[158,245,284],"interleukin":[160],"6":[161],"(IL-6)":[162],"measured":[164],"using":[165],"commercially":[166],"available":[167],"ELISA":[168],"kits":[169],"(Quantikine,":[170],"RD":[171],"Systems).":[172],"RESULTS:":[173],"CHF,":[177],"indices":[179,224],"included":[180],"significantly":[185],"decreased,":[186],"comparison":[194],"control":[197,211],"group.":[198],"whole":[201],"population,":[203],"group,":[212],"significant":[213],"negative":[214,240,277],"correlations":[215,241,278],"observed":[217,293],"level":[220,246,263],"long-term":[222],"such":[225],"as":[226,258,260],"SDNN":[227,248,265],"(r=-0.44;":[228,231,269],"p=0.0006),":[229],"SDANN":[230,251,268],"p=0.0005)":[232,270],"short-time":[234],"index":[235],"SDNNI":[236,255,272],"(r=-0.37;":[237],"p=0.004).":[238],"Similar":[239],"found":[243],"(r=-0.35;":[249],"p=0.007),":[250],"(r=-0.34;":[252,273],"p=0.01),":[253],"(r=-0.31;":[256],"p=0.02),":[257],"well":[259],"IL-6":[262,286],"(r=-0.41;":[266],"p=0.001),":[267],"p=0.009).":[274],"CONCLUSIONS:":[275],"Significant":[276],"TNF-alpha":[280],"sTNF-RI,":[283],"time-domain":[289],"results":[299],"investigations":[301],"conducted":[302],"so":[303],"far":[304],"do":[305],"not":[306],"elucidate":[307],"cause-effect":[309],"relationship,":[310],"further":[311],"studies":[312],"needed":[314],"clarify":[316],"mechanisms":[318],"depression":[321],"severe":[331],"clinical":[332],"condition.":[333]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}