{"id":"https://openalex.org/W2403897681","doi":"https://doi.org/10.1016/s0021-9258(17)34780-4","title":"Human placental amidophosphoribosyltransferase. Comparison of the kinetics of glutamine and ammonia utilization.","display_name":"Human placental amidophosphoribosyltransferase. Comparison of the kinetics of glutamine and ammonia utilization.","publication_year":1978,"publication_date":"1978-06-01","ids":{"openalex":"https://openalex.org/W2403897681","doi":"https://doi.org/10.1016/s0021-9258(17)34780-4","mag":"2403897681","pmid":"https://pubmed.ncbi.nlm.nih.gov/649615"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(17)34780-4","doi":"https://doi.org/10.1016/s0021-9258(17)34780-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)34780-4","pdf_url":"https://doi.org/10.1016/s0021-9258(17)34780-4","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(17)34780-4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009528569","display_name":"George Liang King","orcid":"https://orcid.org/0000-0002-0335-5881","observed_orcids":["https://orcid.org/0000-0002-0335-5881"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.L. King","raw_affiliation_strings":["Division of Rheumatic and Genetic Diseases , Duke University Medical Center , Durham , North Carolina 27710","From the Departments of Medicine and Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatic and Genetic Diseases , Duke University Medical Center , Durham , North Carolina 27710","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"From the Departments of Medicine and Biochemistry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079668688","display_name":"Christine G. Bounous","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.G. Bounous","raw_affiliation_strings":["Division of Rheumatic and Genetic Diseases, Duke University Medical Center, Durham, North Carolina 27710","From the Departments of Medicine and Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatic and Genetic Diseases, Duke University Medical Center, Durham, North Carolina 27710","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"From the Departments of Medicine and Biochemistry,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104043485","display_name":"Edward W. Holmes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E.W. Holmes","raw_affiliation_strings":["From the Departments of Medicine and Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Medicine and Biochemistry,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.9386,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.71200252,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"253","issue":"11","first_page":"3933","last_page":"3938"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.03830000013113022,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amidophosphoribosyltransferase","display_name":"amidophosphoribosyltransferase","score":0.9670000076293945},{"id":"https://openalex.org/keywords/human-placenta","display_name":"human placenta","score":0.9779999852180481},{"id":"https://openalex.org/keywords/glutamine-utilization","display_name":"glutamine utilization","score":0.8600000143051147},{"id":"https://openalex.org/keywords/ammonia-utilization","display_name":"ammonia utilization","score":0.9909999966621399},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.9580000042915344},{"id":"https://openalex.org/keywords/purine-salvage-pathway","display_name":"purine salvage pathway","score":0.6850000023841858},{"id":"https://openalex.org/keywords/nucleotide-metabolism","display_name":"nucleotide metabolism","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.755565881729126},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.6848391890525818},{"id":"https://openalex.org/C2776382133","wikidata":"https://www.wikidata.org/wiki/Q4087","display_name":"Ammonia","level":2,"score":0.5979369282722473},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5113748908042908},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49383553862571716},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2355358600616455},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07095757126808167},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000582","descriptor_name":"Amidophosphoribosyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000641","descriptor_name":"Ammonia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010430","descriptor_name":"Pentosyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010754","descriptor_name":"Phosphoribosyl Pyrophosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(17)34780-4","doi":"https://doi.org/10.1016/s0021-9258(17)34780-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)34780-4","pdf_url":"https://doi.org/10.1016/s0021-9258(17)34780-4","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:649615","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/649615","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(17)34780-4","doi":"https://doi.org/10.1016/s0021-9258(17)34780-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)34780-4","pdf_url":"https://doi.org/10.1016/s0021-9258(17)34780-4","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2403897681.pdf","grobid_xml":"https://content.openalex.org/works/W2403897681.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W154245843","https://openalex.org/W1480307008","https://openalex.org/W1515469702","https://openalex.org/W1543794486","https://openalex.org/W1599144093","https://openalex.org/W1775749144","https://openalex.org/W1894695910","https://openalex.org/W1919986184","https://openalex.org/W1973007489","https://openalex.org/W2008988410","https://openalex.org/W2013259456","https://openalex.org/W2017338565","https://openalex.org/W2023311323","https://openalex.org/W2033271263","https://openalex.org/W2039096297","https://openalex.org/W2109911718","https://openalex.org/W2412552789"],"related_works":["https://openalex.org/W77025200","https://openalex.org/W2434122688","https://openalex.org/W2995504564","https://openalex.org/W1971904636","https://openalex.org/W59071654","https://openalex.org/W2409797008","https://openalex.org/W3090087894","https://openalex.org/W1965146672","https://openalex.org/W1978154028","https://openalex.org/W943953275"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}