{"id":"https://openalex.org/W2403832399","doi":null,"title":"Estimation of the early insulin response to intravenous glucose injection.","display_name":"Estimation of the early insulin response to intravenous glucose injection.","publication_year":1973,"publication_date":"1973-07-01","ids":{"openalex":"https://openalex.org/W2403832399","mag":"2403832399","pmid":"https://pubmed.ncbi.nlm.nih.gov/4717996"},"language":"en","primary_location":{"id":"pmid:4717996","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4717996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063578892","display_name":"Jan I. Thorell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"J I Thorell","raw_affiliation_strings":["From the Department of Pediatrics of the Karolinska Institute, at the st. G\u00f6ran's Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pediatrics of the Karolinska Institute, at the st. G\u00f6ran's Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090245305","display_name":"BERTIL NOSSLIN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"B Nosslin","raw_affiliation_strings":["From the Department of Pediatrics of the Karolinska Institute, at the st. G\u00f6ran's Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pediatrics of the Karolinska Institute, at the st. G\u00f6ran's Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059732480","display_name":"G Sterky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"G Sterky","raw_affiliation_strings":["From the Department of Pediatrics of the Karolinska Institute, at the st. G\u00f6ran's Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pediatrics of the Karolinska Institute, at the st. G\u00f6ran's Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":null,"apc_paid":null,"fwci":3.0966,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.89850586,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"1","first_page":"101","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-insulin-response","display_name":"early insulin response","score":0.9459999799728394},{"id":"https://openalex.org/keywords/intravenous-glucose-tolerance-test","display_name":"intravenous glucose tolerance test","score":0.8849999904632568},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.5759999752044678},{"id":"https://openalex.org/keywords/healthy-volunteers","display_name":"healthy volunteers","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.8691827654838562},{"id":"https://openalex.org/C3017594758","wikidata":"https://www.wikidata.org/wiki/Q776862","display_name":"Insulin response","level":4,"score":0.805046558380127},{"id":"https://openalex.org/C176674119","wikidata":"https://www.wikidata.org/wiki/Q11582","display_name":"Liter","level":2,"score":0.6922888159751892},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5080459117889404},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4981710910797119},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48431602120399475},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.43930286169052124},{"id":"https://openalex.org/C3020574416","wikidata":"https://www.wikidata.org/wiki/Q275157","display_name":"Plasma glucose","level":3,"score":0.4172891080379486},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3346368074417114}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008722","descriptor_name":"Methods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:4717996","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4717996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},{"id":"mag:2403832399","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4717996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W154167904","https://openalex.org/W391400929","https://openalex.org/W1974162921","https://openalex.org/W1979768668","https://openalex.org/W1984667159","https://openalex.org/W1992455574","https://openalex.org/W1994294515","https://openalex.org/W1997417181","https://openalex.org/W2000103012","https://openalex.org/W2001869217","https://openalex.org/W2010270645","https://openalex.org/W2026210921","https://openalex.org/W2027288287","https://openalex.org/W2031988539","https://openalex.org/W2039813542","https://openalex.org/W2041468656","https://openalex.org/W2047975138","https://openalex.org/W2052474142","https://openalex.org/W2060173445","https://openalex.org/W2079254102","https://openalex.org/W2079577855","https://openalex.org/W2083606604","https://openalex.org/W2084245874","https://openalex.org/W2087707464","https://openalex.org/W2088116036","https://openalex.org/W2106634359","https://openalex.org/W2110124224","https://openalex.org/W2117647378","https://openalex.org/W2118104740","https://openalex.org/W2134215219","https://openalex.org/W2135231724","https://openalex.org/W2151479167","https://openalex.org/W2154423252","https://openalex.org/W2166797923","https://openalex.org/W2168774681","https://openalex.org/W2316301388","https://openalex.org/W2316478943","https://openalex.org/W2319776445","https://openalex.org/W2322663730","https://openalex.org/W2410479362","https://openalex.org/W2798643531","https://openalex.org/W2986716542"],"related_works":["https://openalex.org/W2052861702","https://openalex.org/W2418971506","https://openalex.org/W1968342195","https://openalex.org/W1983608229","https://openalex.org/W7099344899","https://openalex.org/W2102847968","https://openalex.org/W2070581697","https://openalex.org/W2010270645","https://openalex.org/W2912257176","https://openalex.org/W2316301388"],"abstract_inverted_index":{"Abstract":[0],"The":[2,19,47,115,165],"early":[3,116,141,195],"insulin":[4,23,48,95,153],"response":[5,88,117,196],"to":[6,51,54,69],"25":[7],"Gm.":[8],"glucose":[9],"intravenously":[10],"was":[11,24,172],"studied":[12,171],"in":[13,42,168],"29":[14],"nonobese,":[15],"apparently":[16],"healthy":[17],"volunteers.":[18],"pattern":[20],"of":[21,60,86,94,105,129,139,149,162,185,193,211],"plasma":[22,158],"followed":[25],"by":[26],"frequent":[27],"sampling":[28,201],"during":[29,202],"15":[30],"minutes.":[31,76,114],"It":[32],"showed":[33,90],"a":[34,65,120,183,188,208],"wide":[35],"variation":[36],"between":[37],"individuals,":[38],"but":[39,108],"certain":[40],"features":[41],"common":[43],"could":[44],"be":[45],"recognized.":[46],"concentration":[49,79],"began":[50],"rise":[52],"1.5":[53],"3":[55,68],"minutes":[56,206],"after":[57,102,207],"the":[58,61,78,87,92,97,103,106,126,136,140,147,150,160,163,169,194,203],"beginning":[59,104],"injection":[62,107,210],"and":[63],"reached":[64],"maximum":[66],"at":[67,74,81,159],"8":[70],"minutes,":[71],"most":[72],"often":[73],"4":[75],"Then,":[77],"declined":[80],"varying":[82],"rates.":[83],"Kinetic":[84],"analysis":[85],"curves":[89],"that":[91,154],"release":[93,128],"from":[96,125,157],"pancreas":[98],"started":[99],"almost":[100],"immediately":[101],"lasted":[109],"for":[110,135,191],"only":[111],"about":[112],"5":[113],"thus":[118],"reflects":[119],"distinct":[121],"phase,":[122],"well":[123],"separated":[124],"later":[127],"insulin.":[130],"A":[131],"method":[132],"is":[133,197],"devised":[134],"quantitative":[137],"estimation":[138],"response,":[142],"taking":[143],"into":[144],"account":[145],"also":[146],"fraction":[148],"newly":[151],"released":[152],"has":[155],"disappeared":[156],"end":[161],"test.":[164],"mean":[166],"value":[167],"group":[170],"51":[173],"\u00b1":[174,180],"31":[175],"\u03bcU":[176],"per":[177],"milliliter":[178],"(mean":[179],"S.D.).":[181],"As":[182],"result":[184],"these":[186],"studies,":[187],"simple":[189],"test":[190],"determination":[192],"proposed,":[198],"based":[199],"on":[200],"first":[204],"10":[205],"single":[209],"glucose.":[212]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}