{"id":"https://openalex.org/W2403781601","doi":"https://doi.org/10.1039/9781849732758-00251","title":"Chapter 12. Mouse Models of Ischemia","display_name":"Chapter 12. Mouse Models of Ischemia","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2403781601","doi":"https://doi.org/10.1039/9781849732758-00251","mag":"2403781601"},"language":"en","primary_location":{"id":"doi:10.1039/9781849732758-00251","doi":"https://doi.org/10.1039/9781849732758-00251","is_oa":false,"landing_page_url":"https://doi.org/10.1039/9781849732758-00251","pdf_url":null,"source":{"id":"https://openalex.org/S4210169072","display_name":"RSC drug discovery/RSC drug discovery series","issn_l":"2041-3203","issn":["2041-3203","2041-3211"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2497074811","display_name":"Animal Models for Neurodegenerative Disease"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002978004","display_name":"David Clifford Henshall","orcid":"https://orcid.org/0000-0001-6237-9632","observed_orcids":["https://orcid.org/0000-0001-6237-9632"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David C. Henshall","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5069808116","display_name":"Roger Pancoast Simon","orcid":"https://orcid.org/0000-0001-7287-6915","observed_orcids":["https://orcid.org/0000-0001-7287-6915"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roger P. Simon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22799296,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"251","last_page":"273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.029100000858306885,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.6259999871253967},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.906000018119812},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.7440000176429749},{"id":"https://openalex.org/keywords/animal-models-of-stroke","display_name":"animal models of stroke","score":0.7149999737739563},{"id":"https://openalex.org/keywords/thromboembolic-stroke","display_name":"thromboembolic stroke","score":0.9750000238418579},{"id":"https://openalex.org/keywords/photothrombotic-stroke","display_name":"photothrombotic stroke","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ischemic-tolerance","display_name":"ischemic tolerance","score":0.8989999890327454},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9660000205039978},{"id":"https://openalex.org/keywords/genetic-models","display_name":"genetic models","score":0.43700000643730164},{"id":"https://openalex.org/keywords/neurological-deficit","display_name":"neurological deficit","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7006422281265259},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6972776651382446},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6740376949310303},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5757799744606018},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.5298355221748352},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.4659610390663147},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.454344242811203},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.45159363746643066},{"id":"https://openalex.org/C2909286980","wikidata":"https://www.wikidata.org/wiki/Q4862390","display_name":"Cerebral ischaemia","level":3,"score":0.44095468521118164},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.34200751781463623},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.33955639600753784},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3004809021949768},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1832931935787201},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1465868055820465},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1039/9781849732758-00251","doi":"https://doi.org/10.1039/9781849732758-00251","is_oa":false,"landing_page_url":"https://doi.org/10.1039/9781849732758-00251","pdf_url":null,"source":{"id":"https://openalex.org/S4210169072","display_name":"RSC drug discovery/RSC drug discovery series","issn_l":"2041-3203","issn":["2041-3203","2041-3211"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4320477085","https://openalex.org/W2241641660","https://openalex.org/W4381433497","https://openalex.org/W2142128874","https://openalex.org/W1859011443","https://openalex.org/W2039501602","https://openalex.org/W2001295404","https://openalex.org/W4255635741","https://openalex.org/W2145240914","https://openalex.org/W2042576684"],"abstract_inverted_index":{"Stroke":[0],"is":[1],"a":[2,17,41,120,135],"leading":[3],"cause":[4],"of":[5,11,23,56,67,87,92,104,126],"death":[6],"and":[7,25,33,52,76,94,97,110,141,147],"disability.":[8],"Animal":[9],"models":[10,58,106,125],"stroke":[12,77],"have":[13,119],"been":[14],"developed":[15],"as":[16],"means":[18],"to":[19,29,43,61,113],"characterize":[20],"the":[21,34,62,85,102,115,144],"pathophysiology":[22],"ischemia":[24],"evaluate":[26],"therapeutic":[27],"treatments":[28],"alleviate":[30],"brain":[31],"damage":[32],"attendant":[35],"neurologic":[36],"deficits.":[37],"Mice":[38],"offer":[39],"investigators":[40],"way":[42],"address":[44],"specific":[45],"gene":[46],"effects":[47],"including":[48,64],"mutations,":[49],"complete":[50],"deletions":[51],"overexpression.":[53],"A":[54],"plethora":[55],"mouse":[57,124],"are":[59],"available":[60],"investigator":[63],"surgical":[65],"occlusion":[66],"major":[68],"cerebral":[69],"arteries,":[70],"intraluminal":[71],"filament":[72],"occlusion,":[73],"thromboembolic,":[74],"photothrombotic":[75],"induced":[78],"by":[79],"pharmacologic":[80,111],"vasoconstrictors.":[81],"This":[82],"chapter":[83],"describes":[84],"origins":[86],"these":[88,105],"models,":[89],"technical":[90],"aspects":[91],"procedures,":[93],"their":[95],"strengths":[96],"weaknesses.":[98],"We":[99],"also":[100],"highlight":[101,143],"utility":[103],"for":[107],"investigating":[108],"genetic":[109],"strategies":[112],"protect":[114],"brain.":[116],"Last,":[117],"we":[118,142],"special":[121],"focus":[122],"on":[123],"ischemic":[127,132,137],"tolerance,":[128],"whereby":[129],"brief,":[130],"non-harmful":[131],"episodes":[133],"preceding":[134],"prolonged":[136],"event":[138],"reduce":[139],"damage,":[140],"emerging":[145],"cell":[146],"molecular":[148],"mediators":[149],"thereof.":[150]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}