{"id":"https://openalex.org/W2403766503","doi":null,"title":"Gut peptides in gastrointestinal motility and mucosal permeability","display_name":"Gut peptides in gastrointestinal motility and mucosal permeability","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2403766503","mag":"2403766503"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-294390","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-294390","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-294390","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056679669","display_name":"Md Abdul Halim","orcid":"https://orcid.org/0000-0001-6220-3936","observed_orcids":["https://orcid.org/0000-0001-6220-3936"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Md Abdul Halim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6220-3936","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5056679669"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.8051999807357788,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.8051999807357788,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.19210000336170197,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-peptides","display_name":"gut peptides","score":0.7289999723434448},{"id":"https://openalex.org/keywords/gastrointestinal-motility","display_name":"gastrointestinal motility","score":0.871999979019165},{"id":"https://openalex.org/keywords/mucosal-permeability","display_name":"mucosal permeability","score":0.8650000095367432},{"id":"https://openalex.org/keywords/neuropeptide-s","display_name":"neuropeptide S","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nitric-oxide-signaling","display_name":"nitric oxide signaling","score":0.746999979019165},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9660000205039978},{"id":"https://openalex.org/keywords/migrating-motor-complex","display_name":"migrating motor complex","score":0.7039999961853027},{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.7360000014305115},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.4779999852180481},{"id":"https://openalex.org/keywords/exendin-9-39","display_name":"exendin-9-39","score":0.828000009059906},{"id":"https://openalex.org/keywords/intestinal-smooth-muscle-relaxation","display_name":"intestinal smooth muscle relaxation","score":0.4339999854564667},{"id":"https://openalex.org/keywords/autonomic-nervous-system","display_name":"autonomic nervous system","score":0.5139999985694885},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.4009999930858612},{"id":"https://openalex.org/keywords/satiety","display_name":"satiety","score":0.36800000071525574}],"concepts":[{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.6037716865539551},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.4205205738544464},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33500659465789795},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2514224052429199},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24282389879226685},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.22600063681602478},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1865517795085907}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-294390","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-294390","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2403766503","doi":null,"is_oa":false,"landing_page_url":"https://uu.diva-portal.org/smash/record.jsf?pid=diva2:929780","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-294390","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-294390","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":165,"referenced_works":["https://openalex.org/W75924356","https://openalex.org/W160591056","https://openalex.org/W184898749","https://openalex.org/W253024971","https://openalex.org/W1031133529","https://openalex.org/W1523737655","https://openalex.org/W1552685796","https://openalex.org/W1554042779","https://openalex.org/W1559708388","https://openalex.org/W1561454056","https://openalex.org/W1573166409","https://openalex.org/W1573746155","https://openalex.org/W1590886519","https://openalex.org/W1599990276","https://openalex.org/W1618627661","https://openalex.org/W1764580333","https://openalex.org/W1786092055","https://openalex.org/W1787864273","https://openalex.org/W1821549997","https://openalex.org/W1896814935","https://openalex.org/W1964212912","https://openalex.org/W1964616397","https://openalex.org/W1969062424","https://openalex.org/W1973914239","https://openalex.org/W1974156538","https://openalex.org/W1974584320","https://openalex.org/W1976623507","https://openalex.org/W1976707575","https://openalex.org/W1976781959","https://openalex.org/W1977226383","https://openalex.org/W1977789326","https://openalex.org/W1979410480","https://openalex.org/W1979948289","https://openalex.org/W1980986949","https://openalex.org/W1981500222","https://openalex.org/W1983251816","https://openalex.org/W1983967545","https://openalex.org/W1989339210","https://openalex.org/W1991104375","https://openalex.org/W1992780204","https://openalex.org/W1993285386","https://openalex.org/W1994105452","https://openalex.org/W1995932778","https://openalex.org/W1996308506","https://openalex.org/W1996311047","https://openalex.org/W1997187593","https://openalex.org/W2000256930","https://openalex.org/W2003107596","https://openalex.org/W2006403332","https://openalex.org/W2007180427","https://openalex.org/W2008411184","https://openalex.org/W2010591751","https://openalex.org/W2013745847","https://openalex.org/W2014791743","https://openalex.org/W2016732441","https://openalex.org/W2016850782","https://openalex.org/W2018111225","https://openalex.org/W2018815492","https://openalex.org/W2019116731","https://openalex.org/W2019680440","https://openalex.org/W2019847021","https://openalex.org/W2022101780","https://openalex.org/W2024390522","https://openalex.org/W2024878334","https://openalex.org/W2025027007","https://openalex.org/W2025175237","https://openalex.org/W2025261063","https://openalex.org/W2025451832","https://openalex.org/W2025610141","https://openalex.org/W2027593203","https://openalex.org/W2028020939","https://openalex.org/W2028224423","https://openalex.org/W2030364983","https://openalex.org/W2034136462","https://openalex.org/W2034530919","https://openalex.org/W2038100952","https://openalex.org/W2039707270","https://openalex.org/W2041037597","https://openalex.org/W2041150765","https://openalex.org/W2043220334","https://openalex.org/W2049715418","https://openalex.org/W2049848329","https://openalex.org/W2050775539","https://openalex.org/W2051881849","https://openalex.org/W2052690953","https://openalex.org/W2052695494","https://openalex.org/W2053559093","https://openalex.org/W2057283335","https://openalex.org/W2061202826","https://openalex.org/W2061274996","https://openalex.org/W2061371873","https://openalex.org/W2064203348","https://openalex.org/W2068183831","https://openalex.org/W2070051672","https://openalex.org/W2071732712","https://openalex.org/W2075124455","https://openalex.org/W2076872340","https://openalex.org/W2078621117","https://openalex.org/W2079226021","https://openalex.org/W2079625010","https://openalex.org/W2084142744","https://openalex.org/W2085560320","https://openalex.org/W2087849042","https://openalex.org/W2091428206","https://openalex.org/W2093028618","https://openalex.org/W2093243462","https://openalex.org/W2094464340","https://openalex.org/W2094537367","https://openalex.org/W2097325055","https://openalex.org/W2097369897","https://openalex.org/W2098267014","https://openalex.org/W2100440460","https://openalex.org/W2100723130","https://openalex.org/W2104723919","https://openalex.org/W2105279117","https://openalex.org/W2106607972","https://openalex.org/W2106939044","https://openalex.org/W2108700009","https://openalex.org/W2111063087","https://openalex.org/W2115285670","https://openalex.org/W2116260634","https://openalex.org/W2116289754","https://openalex.org/W2116429899","https://openalex.org/W2119427815","https://openalex.org/W2119670027","https://openalex.org/W2120846734","https://openalex.org/W2121354128","https://openalex.org/W2121361277","https://openalex.org/W2122341732","https://openalex.org/W2123686656","https://openalex.org/W2126842710","https://openalex.org/W2128681736","https://openalex.org/W2130876080","https://openalex.org/W2131112248","https://openalex.org/W2131691531","https://openalex.org/W2131766686","https://openalex.org/W2131917464","https://openalex.org/W2140929617","https://openalex.org/W2143587740","https://openalex.org/W2143625465","https://openalex.org/W2144603992","https://openalex.org/W2145243587","https://openalex.org/W2148614122","https://openalex.org/W2149893688","https://openalex.org/W2151417532","https://openalex.org/W2151811075","https://openalex.org/W2152165298","https://openalex.org/W2155187577","https://openalex.org/W2155337537","https://openalex.org/W2156484886","https://openalex.org/W2161238054","https://openalex.org/W2162647412","https://openalex.org/W2166073051","https://openalex.org/W2169050068","https://openalex.org/W2169768464","https://openalex.org/W2170048668","https://openalex.org/W2170504015","https://openalex.org/W2171950662","https://openalex.org/W2173353533","https://openalex.org/W2176544002","https://openalex.org/W2313658489","https://openalex.org/W2335063073","https://openalex.org/W2343564993","https://openalex.org/W2505156394","https://openalex.org/W4249236850"],"related_works":["https://openalex.org/W1764580333","https://openalex.org/W1413577516","https://openalex.org/W1984382423","https://openalex.org/W2071956075","https://openalex.org/W2025261063","https://openalex.org/W2769448074","https://openalex.org/W1992713989","https://openalex.org/W2063536623","https://openalex.org/W7047429496","https://openalex.org/W2017034820"],"abstract_inverted_index":{"Gut":[0],"regulatory":[1],"peptides,":[2],"such":[3],"as":[4,119,134],"neuropeptides":[5],"and":[6,14,17,41,56,60,69,85,92,101,124,153,180,232,277,280,305,329,331,346],"incretins,":[7],"play":[8],"important":[9],"roles":[10],"in":[11,34,39,45,58,83,107,217,222,262,285,309],"hunger,":[12],"satiety":[13],"gastrointestinal":[15],"motility,":[16],"possibly":[18],"mucosal":[19,35,42],"permeability.":[20,61],"Many":[21],"peptides":[22],"secreted":[23],"by":[24,205,253,291],"myenteric":[25,186,264,310],"nerves":[26],"that":[27,163,169],"regulate":[28],"motor":[29],"control":[30],"are":[31],"also":[32],"produced":[33],"epithelial":[36],"cells.":[37],"Derangements":[38],"motility":[40,59,84,108,219,234,272,345],"permeability":[43,73,113,141,155,320,347],"occur":[44],"many":[46],"diseases.":[47],"Current":[48],"knowledge":[49],"is":[50],"fragmentary":[51],"regarding":[52],"gut":[53,72],"peptide":[54,98],"actions":[55],"mechanisms":[57,95,325],"This":[62,143],"thesis":[63],"aimed":[64],"to":[65,130,176,193],"1)":[66],"develop":[67],"probes":[68],"methods":[70],"for":[71,137,319],"testing,":[74],"2)":[75],"elucidate":[76],"the":[77,102,125,131,177,263,337],"role":[78],"of":[79,96,273,326,339],"neuropeptide":[80],"S":[81],"(NPS)":[82],"permeability,":[86],"3)":[87],"characterize":[88,94],"nitrergic":[89,328],"muscle":[90,151,167,286],"relaxation":[91,152,168],"4)":[93],"glucagon-like":[97],"1":[99],"(GLP-1)":[100],"drug":[103],"ROSE-010":[104,281,332],"(GLP-1":[105],"analog)":[106],"inhibition.":[109],"A":[110],"rapid":[111,317],"fluorescent":[112],"test":[114],"was":[115,170,190,260,289,348],"developed":[116,322],"using":[117],"riboflavin":[118],"a":[120,135,139,145,341],"transcellular":[121],"transport":[122],"probe":[123],"bisboronic":[126],"acid":[127],"4,4'oBBV":[128],"coupled":[129],"fluorophore":[132],"HPTS":[133],"sensor":[136],"lactulose,":[138],"paracellular":[140],"probe.":[142],"yielded":[144],"lactulose:riboflavin":[146],"ratio":[147],"test.":[148],"NPS":[149,164,179,189,197],"induced":[150,165],"increased":[154,271],"through":[156],"NO-dependent":[157,166],"mechanisms.":[158,201],"Organ":[159],"bath":[160],"studies":[161],"revealed":[162],"tetrodotoxin":[171],"(TTX)":[172],"sensitive.":[173],"In":[174,315,336],"addition":[175],"epithelium,":[178],"its":[181],"receptor":[182,293],"NPSR1":[183],"localized":[184],"at":[185],"nerves.":[187],"Circulating":[188],"too":[191],"low":[192],"activate":[194],"NPSR1,":[195],"indicating":[196],"uses":[198],"local":[199],"autocrine/paracrine":[200],"Nitrergic":[202],"signaling":[203,333],"inhibition":[204],"nitric":[206],"oxide":[207],"synthase":[208],"inhibitor":[209,300],"L-NMMA":[210,224],"elicited":[211],"premature":[212],"duodenojejunal":[213],"phase":[214,230,236,242],"III":[215],"contractions":[216,250,284],"migrating":[218],"complex":[220],"(MMC)":[221],"humans.":[223],"shortened":[225],"MMC":[226],"cycle":[227],"length,":[228],"suppressed":[229],"I":[231],"shifted":[233],"towards":[235],"II.":[237],"Pre-treatment":[238],"with":[239],"atropine":[240],"extended":[241],"II,":[243],"while":[244,323],"ondansetron":[245],"had":[246],"no":[247],"effect.":[248],"Intestinal":[249],"were":[251,307,321,334],"stimulated":[252],"L-NMMA,":[254,297],"but":[255,266,312],"not":[256,267,313],"TTX.":[257,303],"NOS":[258],"immunoreactivity":[259],"detected":[261],"plexus":[265],"smooth":[268],"muscle.":[269,314],"Food-intake":[270],"human":[274],"antrum,":[275],"duodenum":[276],"jejunum.":[278],"GLP-1":[279,292,330],"relaxed":[282],"bethanechol-induced":[283],"strips.":[287],"Relaxation":[288],"blocked":[290],"antagonist":[294],"exendin(9-39)":[295],"amide,":[296],"adenylate":[298],"cyclase":[299],"2\u00b45\u00b4-dideoxyadenosine":[301],"or":[302],"GLP-1R":[304],"GLP-2R":[306],"expressed":[308],"neurons,":[311],"conclusion,":[316],"chemistries":[318],"physiological":[324],"NPS,":[327,340],"revealed.":[335],"case":[338],"tight":[342],"synchrony":[343],"between":[344],"found.":[349]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
