{"id":"https://openalex.org/W2403732318","doi":null,"title":"Gene Regulation in Neuronal Degeneration - Role of mSin3 and YY1 factors","display_name":"Gene Regulation in Neuronal Degeneration - Role of mSin3 and YY1 factors","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2403732318","mag":"2403732318"},"language":"en","primary_location":{"id":"mag:2403732318","doi":null,"is_oa":false,"landing_page_url":"https://www.uef.fi/documents/1085457/1371730/61the.pdf/e942c639-9d4f-4817-8520-67c1dff012d9","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070002020","display_name":"Pauliina Korhonen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pauliina Korhonen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5070002020"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6692,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.64266164,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.08649999648332596,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.026100000366568565,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9589999914169312},{"id":"https://openalex.org/keywords/msin3a","display_name":"mSin3A","score":0.8339999914169312},{"id":"https://openalex.org/keywords/yy1","display_name":"YY1","score":0.8379999995231628},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.8790000081062317},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.9860000014305115},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.9940000176429749},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.6880000233650208},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9300000071525574},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5289999842643738},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.7350000143051147},{"id":"https://openalex.org/keywords/dna-binding-activity","display_name":"DNA-binding activity","score":0.6669999957084656},{"id":"https://openalex.org/keywords/neuro-2a-cells","display_name":"N2a cells","score":0.8029999732971191},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cerebellar-granule-cells","display_name":"cerebellar granule cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/trichostatin-a","display_name":"trichostatin A","score":0.9100000262260437}],"concepts":[{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.7791454792022705},{"id":"https://openalex.org/C62944979","wikidata":"https://www.wikidata.org/wiki/Q18032405","display_name":"YY1","level":5,"score":0.7636889219284058},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6095327734947205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5468976497650146},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5216101408004761},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.49181440472602844},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.47803840041160583},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4342890977859497},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.43284308910369873},{"id":"https://openalex.org/C2777865847","wikidata":"https://www.wikidata.org/wiki/Q425894","display_name":"Trichostatin A","level":5,"score":0.4278908967971802},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.37735939025878906},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.37390798330307007},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.37140822410583496},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.359256386756897},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34674370288848877},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.31672680377960205},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2287483513355255},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15446153283119202},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06717750430107117},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2403732318","doi":null,"is_oa":false,"landing_page_url":"https://www.uef.fi/documents/1085457/1371730/61the.pdf/e942c639-9d4f-4817-8520-67c1dff012d9","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":288,"referenced_works":["https://openalex.org/W6719581","https://openalex.org/W30031754","https://openalex.org/W36925602","https://openalex.org/W78763444","https://openalex.org/W85263004","https://openalex.org/W104539405","https://openalex.org/W111663151","https://openalex.org/W114154610","https://openalex.org/W151363419","https://openalex.org/W410076493","https://openalex.org/W609348642","https://openalex.org/W1486257535","https://openalex.org/W1488115555","https://openalex.org/W1500106790","https://openalex.org/W1511815964","https://openalex.org/W1512414376","https://openalex.org/W1525573602","https://openalex.org/W1540264737","https://openalex.org/W1544589833","https://openalex.org/W1558122435","https://openalex.org/W1559742681","https://openalex.org/W1560485148","https://openalex.org/W1562792231","https://openalex.org/W1583104418","https://openalex.org/W1587031596","https://openalex.org/W1587947784","https://openalex.org/W1592716123","https://openalex.org/W1605104953","https://openalex.org/W1605878810","https://openalex.org/W1635667563","https://openalex.org/W1643390591","https://openalex.org/W1644144652","https://openalex.org/W1665024321","https://openalex.org/W1689569903","https://openalex.org/W1771253106","https://openalex.org/W1784857457","https://openalex.org/W1797937888","https://openalex.org/W1813154396","https://openalex.org/W1821654469","https://openalex.org/W1867673778","https://openalex.org/W1882033673","https://openalex.org/W1900402474","https://openalex.org/W1920602060","https://openalex.org/W1942214720","https://openalex.org/W1943233864","https://openalex.org/W1961082018","https://openalex.org/W1963879245","https://openalex.org/W1966156883","https://openalex.org/W1966322170","https://openalex.org/W1966472337","https://openalex.org/W1966819401","https://openalex.org/W1967544492","https://openalex.org/W1967769642","https://openalex.org/W1968151995","https://openalex.org/W1969373767","https://openalex.org/W1969420903","https://openalex.org/W1970316586","https://openalex.org/W1970546664","https://openalex.org/W1972340735","https://openalex.org/W1973031832","https://openalex.org/W1973130935","https://openalex.org/W1973672022","https://openalex.org/W1973962332","https://openalex.org/W1974112332","https://openalex.org/W1976967609","https://openalex.org/W1977130958","https://openalex.org/W1977690815","https://openalex.org/W1980483123","https://openalex.org/W1981591956","https://openalex.org/W1981883990","https://openalex.org/W1982647833","https://openalex.org/W1982685209","https://openalex.org/W1984164498","https://openalex.org/W1984903030","https://openalex.org/W1987808828","https://openalex.org/W1987851611","https://openalex.org/W1988043250","https://openalex.org/W1988825889","https://openalex.org/W1988925814","https://openalex.org/W1989429888","https://openalex.org/W1991865867","https://openalex.org/W1993204509","https://openalex.org/W1994820200","https://openalex.org/W1995188451","https://openalex.org/W1995514235","https://openalex.org/W1995650022","https://openalex.org/W1995865634","https://openalex.org/W1995902306","https://openalex.org/W1997555550","https://openalex.org/W1997986614","https://openalex.org/W1999330214","https://openalex.org/W1999510229","https://openalex.org/W1999874171","https://openalex.org/W1999952815","https://openalex.org/W2000490360","https://openalex.org/W2001316126","https://openalex.org/W2001356550","https://openalex.org/W2001711719","https://openalex.org/W2002179539","https://openalex.org/W2003536297","https://openalex.org/W2003801881","https://openalex.org/W2003891141","https://openalex.org/W2004002095","https://openalex.org/W2004314923","https://openalex.org/W2005133915","https://openalex.org/W2006295023","https://openalex.org/W2006376420","https://openalex.org/W2006445962","https://openalex.org/W2007884336","https://openalex.org/W2008431386","https://openalex.org/W2010048885","https://openalex.org/W2010745413","https://openalex.org/W2011263116","https://openalex.org/W2011625842","https://openalex.org/W2012054900","https://openalex.org/W2013224893","https://openalex.org/W2013289541","https://openalex.org/W2014817033","https://openalex.org/W2016293448","https://openalex.org/W2016567695","https://openalex.org/W2017356757","https://openalex.org/W2020624387","https://openalex.org/W2020824064","https://openalex.org/W2021943181","https://openalex.org/W2022561772","https://openalex.org/W2022891913","https://openalex.org/W2023831571","https://openalex.org/W2023887736","https://openalex.org/W2024592308","https://openalex.org/W2024909125","https://openalex.org/W2025128734","https://openalex.org/W2025438239","https://openalex.org/W2025824385","https://openalex.org/W2026290399","https://openalex.org/W2026393778","https://openalex.org/W2026441085","https://openalex.org/W2027236454","https://openalex.org/W2028725230","https://openalex.org/W2028735905","https://openalex.org/W2030509081","https://openalex.org/W2031825480","https://openalex.org/W2032474463","https://openalex.org/W2032754080","https://openalex.org/W2032770280","https://openalex.org/W2033097911","https://openalex.org/W2034207297","https://openalex.org/W2034792033","https://openalex.org/W2035657750","https://openalex.org/W2036303275","https://openalex.org/W2036475318","https://openalex.org/W2036639816","https://openalex.org/W2037738220","https://openalex.org/W2039479984","https://openalex.org/W2040547747","https://openalex.org/W2041301785","https://openalex.org/W2042222447","https://openalex.org/W2042315437","https://openalex.org/W2044559869","https://openalex.org/W2044735117","https://openalex.org/W2049594669","https://openalex.org/W2052853635","https://openalex.org/W2054160125","https://openalex.org/W2054696920","https://openalex.org/W2056108005","https://openalex.org/W2056572328","https://openalex.org/W2056695281","https://openalex.org/W2057564306","https://openalex.org/W2057753203","https://openalex.org/W2060595700","https://openalex.org/W2060696024","https://openalex.org/W2061497413","https://openalex.org/W2062414406","https://openalex.org/W2063460322","https://openalex.org/W2063897425","https://openalex.org/W2063910839","https://openalex.org/W2064667001","https://openalex.org/W2067856703","https://openalex.org/W2067878123","https://openalex.org/W2068366145","https://openalex.org/W2069125659","https://openalex.org/W2069450754","https://openalex.org/W2069681995","https://openalex.org/W2070437897","https://openalex.org/W2070964315","https://openalex.org/W2071940267","https://openalex.org/W2071981322","https://openalex.org/W2072375912","https://openalex.org/W2073293518","https://openalex.org/W2074096799","https://openalex.org/W2075038429","https://openalex.org/W2077150554","https://openalex.org/W2078297328","https://openalex.org/W2082582109","https://openalex.org/W2082876519","https://openalex.org/W2082878743","https://openalex.org/W2084214593","https://openalex.org/W2087203311","https://openalex.org/W2087427344","https://openalex.org/W2087481253","https://openalex.org/W2087496042","https://openalex.org/W2087560360","https://openalex.org/W2087650843","https://openalex.org/W2089760888","https://openalex.org/W2090051505","https://openalex.org/W2090898691","https://openalex.org/W2092492901","https://openalex.org/W2093056529","https://openalex.org/W2093147895","https://openalex.org/W2094991297","https://openalex.org/W2095025678","https://openalex.org/W2095115211","https://openalex.org/W2095953267","https://openalex.org/W2096008106","https://openalex.org/W2096497154","https://openalex.org/W2098324936","https://openalex.org/W2098919421","https://openalex.org/W2100743187","https://openalex.org/W2101108802","https://openalex.org/W2104744253","https://openalex.org/W2104788426","https://openalex.org/W2106582601","https://openalex.org/W2106900373","https://openalex.org/W2107660103","https://openalex.org/W2107813123","https://openalex.org/W2107855944","https://openalex.org/W2108508097","https://openalex.org/W2109881276","https://openalex.org/W2111417422","https://openalex.org/W2112367847","https://openalex.org/W2112425896","https://openalex.org/W2113556902","https://openalex.org/W2113611418","https://openalex.org/W2113999599","https://openalex.org/W2114108390","https://openalex.org/W2115351711","https://openalex.org/W2118862408","https://openalex.org/W2119093680","https://openalex.org/W2120057014","https://openalex.org/W2121802881","https://openalex.org/W2122609109","https://openalex.org/W2122631256","https://openalex.org/W2125475384","https://openalex.org/W2127201083","https://openalex.org/W2127311839","https://openalex.org/W2127321901","https://openalex.org/W2128154787","https://openalex.org/W2132794393","https://openalex.org/W2135085078","https://openalex.org/W2137546188","https://openalex.org/W2137915568","https://openalex.org/W2139168442","https://openalex.org/W2139996002","https://openalex.org/W2141373343","https://openalex.org/W2143206501","https://openalex.org/W2143579765","https://openalex.org/W2146859442","https://openalex.org/W2148674361","https://openalex.org/W2149031125","https://openalex.org/W2149357952","https://openalex.org/W2149706478","https://openalex.org/W2150082378","https://openalex.org/W2151501496","https://openalex.org/W2151514212","https://openalex.org/W2154107855","https://openalex.org/W2154185970","https://openalex.org/W2156152760","https://openalex.org/W2156179144","https://openalex.org/W2158301564","https://openalex.org/W2159299465","https://openalex.org/W2159836860","https://openalex.org/W2159909619","https://openalex.org/W2163046373","https://openalex.org/W2164380111","https://openalex.org/W2166082601","https://openalex.org/W2166156797","https://openalex.org/W2166984732","https://openalex.org/W2168983364","https://openalex.org/W2170249039","https://openalex.org/W2171852242","https://openalex.org/W2172256092","https://openalex.org/W2312913993","https://openalex.org/W2406868494","https://openalex.org/W2434712291","https://openalex.org/W2576734941","https://openalex.org/W2790725995","https://openalex.org/W3023167551","https://openalex.org/W3094555158","https://openalex.org/W4241801755"],"related_works":["https://openalex.org/W2037832007","https://openalex.org/W2007776914","https://openalex.org/W2032160675","https://openalex.org/W7206782768","https://openalex.org/W2113037810","https://openalex.org/W2997146877","https://openalex.org/W1999874171","https://openalex.org/W7097308415","https://openalex.org/W3123664404","https://openalex.org/W2793061482"],"abstract_inverted_index":{"In":[0],"neurodegenerative":[1],"disorders,":[2],"neural":[3],"cells":[4,169,190,280,363],"can":[5,364],"die":[6],"through":[7,119],"two":[8,60],"distinctive":[9],"cell":[10,19],"death":[11,20],"processes,":[12],"apoptosis":[13,195,338,357,497],"and":[14,26,30,38,48,55,69,103,113,123,144,151,170,175,187,196,205,358,371,383,456,485,498,509,563],"excitotoxicity.":[15,352],"Both":[16],"of":[17,36,73,101,140,165,228,272,277,290,294,303,347,369,377,391,405,434,450,454,463,483,515,524],"these":[18],"processes":[21],"involve":[22],"changes":[23,44,136,159,341,392,398,429],"in":[24,33,65,110,137,160,167,193,234,247,258,287,309,330,342,361,381,393,400,422,430,439,465,471,480],"mRNA":[25,150,451],"protein":[27,49,152,214,237,367,453,488,517],"synthesis":[28,50,489],"rates":[29],"thus":[31],"alterations":[32],"the":[34,46,93,97,111,121,135,138,149,161,194,212,231,235,244,288,291,304,324,343,366,374,389,401,411,423,431,435,448,460,481,504,513],"level":[35,326],"transcription":[37,549],"translation.":[39],"Age-related":[40],"neuronal":[41,168,279,362,520],"degeneration":[42],"involves":[43],"at":[45,148],"transcriptional":[47,66,116,395,505],"level.":[51],"Transcription":[52],"factor":[53,142],"YY1":[54,68,122,143,166,295,306,348,378,394,406,457,464,510],"adaptor":[56,145],"molecule":[57],"mSin3":[58,70,124,484],"are":[59,63,71],"proteins":[61,100],"which":[62,416],"involved":[64],"repression.":[67,117],"units":[72],"separate":[74],"complexes":[75,125,321,346,376,404],"where":[76],"their":[77],"repressive":[78],"function":[79],"is":[80,265],"attributable":[81],"to":[82,87,106,115,133,157,267,281,296,323,410,476],"several":[83,419],"other":[84],"participants,":[85],"mostly":[86],"histone":[88,99],"deacetylases":[89],"(HDACs).":[90],"HDACs":[91],"remove":[92],"acetyl":[94],"groups":[95],"from":[96,203],"core":[98],"nucleosomes,":[102],"this":[104],"leads":[105],"a":[107,224,269,284,314,478,495],"conformational":[108],"change":[109,286,365,518],"nucleosome":[112],"further":[114,417],"Thus,":[118,469],"HDACs,":[120,229],"regulate":[126],"gene":[127,540,554],"expression":[128,139,449,555],"activity.":[129],"Our":[130],"aim":[131],"was":[132],"investigate":[134],"transcripton":[141],"molecules":[146],"mSin3A/B":[147,455],"levels":[153,218,368],"as":[154,156,181,183,349],"well":[155,182],"measure":[158],"DNA":[162,298,344,402],"binding":[163,292,299,302,345,375,403],"activity":[164,257,264],"tissues":[171],"during":[172,492,519],"apoptosis,":[173,387],"excitotoxicity":[174,197,382],"aging.":[176,493],"Mouse":[177],"Neuro-2a":[178,248],"neuroblastoma":[179],"cells,":[180,249],"rat":[184,466],"primary":[185,259,278],"hippocampal":[186],"cerebellar":[188,260],"granule":[189,261],"were":[191,201,379],"used":[192],"studies.":[198],"Tissue":[199],"samples":[200,311],"taken":[202],"young":[204],"old":[206],"rats.":[207],"Several":[208],"apoptotic":[209,240],"inducers":[210,241],"increased":[211,243],"mSin3A":[213,236,370,508],"levels,":[215],"but":[216,500],"mSin3B":[217],"remained":[219],"unchanged.":[220],"Trichostatin":[221],"A":[222,274],"(TSA),":[223],"specific":[225],"inhib":[226],"itor":[227],"induced":[230,283,386,413,428],"strongest":[232],"increase":[233],"expression.":[238],"All":[239],"significantly":[242],"caspase-3":[245,256],"activities":[246],"whereas":[250],"etoposide":[251],"did":[252,350,441],"not":[253,442,474,501],"induce":[254],"any":[255,444],"cells.":[262],"Caspase-3":[263],"considered":[266],"be":[268,408],"reliable":[270],"marker":[271],"apoptosis.":[273],"brief":[275],"exposure":[276],"glutamate":[282,412],"dramatic":[285],"size":[289],"complex":[293,307,317,461],"its":[297],"site.":[300],"The":[301,397],"normal":[305],"present":[308],"control":[310],"disappeared":[312],"while":[313],"new,":[315],"smaller":[316],"appeared.":[318],"However,":[319],"both":[320],"shifted":[322],"same":[325],"with":[327],"anti-YY1":[328],"antibody":[329],"EMSA-supershift":[331],"assays.":[332],"Interestingly,":[333],"also":[334],"okadaic":[335,384,426],"acid":[336,385,427],"-induced":[337],"caused":[339],"similar":[340],"glutamate-induced":[351],"These":[353],"results":[354],"indicate":[355],"that":[356,512],"excitotoxic":[359],"shock":[360],"YY1.":[372],"Also":[373],"disrupted":[380],"highlighting":[388],"role":[390,479],"regulation.":[396],"seen":[399],"may":[407],"due":[409],"Ca":[414],"influx,":[415],"activates":[418],"signalling":[420],"cascades":[421],"cell,":[424],"or":[425,452,458],"phosphorylation":[432],"status":[433],"cellular":[436],"proteins.":[437],"Aging":[438],"vivo":[440,472],"have":[443,477],"effect":[445],"on":[446,459],"either":[447],"formation":[462],"brain":[467],"samples.":[468],"aging":[470],"does":[473],"seem":[475],"regulation":[482],"YY1,":[486],"although":[487],"slows":[490],"down":[491],"As":[494],"conclusion,":[496],"excitotoxicity,":[499],"aging,":[502],"affected":[503],"repressor":[506],"factors":[507],"indicating":[511],"roles":[514],"those":[516],"degeneration.":[521],"National":[522],"Library":[523],"Medicine":[525],"Classification:":[526],"WL":[527,529],"359,":[528],"102.5":[530],"Medical":[531],"Subject":[532],"Headings:":[533],"transcription,":[534],"genetic;":[535],"apoptosis;":[536],"aging;":[537],"neurons;":[538],"neuroblastoma/cytology;":[539],"expression;":[541],"blotting,":[542,544],"Northern;":[543],"Western;":[545],"electrophoretic":[546],"mobility":[547],"assay;":[548],"factors;":[550],"excitatory":[551],"amino":[552],"acids;":[553],"regulation;":[556],"down-regulation/genetics;":[557],"DNA-binding":[558],"proteins/genetics":[559],"To":[560],"Jarmo,":[561],"Akuliina":[562],"Aukusti":[564]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}