{"id":"https://openalex.org/W2403662924","doi":null,"title":"Intrathecal cannabinoid administration suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in rat spinal cord: comparison with morphine.","display_name":"Intrathecal cannabinoid administration suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in rat spinal cord: comparison with morphine.","publication_year":1999,"publication_date":"1999-12-01","ids":{"openalex":"https://openalex.org/W2403662924","mag":"2403662924","pmid":"https://pubmed.ncbi.nlm.nih.gov/11216448"},"language":"en","primary_location":{"id":"pmid:11216448","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11216448","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo yao li xue bao = Acta pharmacologica Sinica","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012489562","display_name":"Andrea G. Hohmann","orcid":"https://orcid.org/0000-0003-0941-6435","observed_orcids":["https://orcid.org/0000-0003-0941-6435"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A G Hohmann","raw_affiliation_strings":["Schrier Research Laboratory, Department of Psychology, Brown University, Providence, RI 02912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schrier Research Laboratory, Department of Psychology, Brown University, Providence, RI 02912, USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110018334","display_name":"K Tsou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Tsou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"J M Walker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Walker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1139,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.77460794,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"20","issue":"12","first_page":"1132","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.6455000042915344,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.6455000042915344,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.3508000075817108,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cannabinoids","display_name":"cannabinoids","score":0.8600000143051147},{"id":"https://openalex.org/keywords/intrathecal-administration","display_name":"intrathecal administration","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cp-55-940","display_name":"CP55,940","score":0.9350000023841858},{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.9380000233650208},{"id":"https://openalex.org/keywords/fos-protein","display_name":"Fos protein","score":0.75},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.652999997138977},{"id":"https://openalex.org/keywords/spinal-cord-dorsal-horn","display_name":"dorsal horn","score":0.8299999833106995},{"id":"https://openalex.org/keywords/anterior-horn","display_name":"ventral horn","score":0.8180000185966492},{"id":"https://openalex.org/keywords/formalin-test","display_name":"formalin test","score":0.8519999980926514},{"id":"https://openalex.org/keywords/nociceptive-processing","display_name":"nociceptive processing","score":0.8320000171661377},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.8560000061988831},{"id":"https://openalex.org/keywords/opioid-analgesics","display_name":"opioid analgesics","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C104211972","wikidata":"https://www.wikidata.org/wiki/Q7067309","display_name":"Noxious stimulus","level":4,"score":0.6984045505523682},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.6905839443206787},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.6874223947525024},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.6766515970230103},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.6286899447441101},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6003901958465576},{"id":"https://openalex.org/C52396799","wikidata":"https://www.wikidata.org/wiki/Q7676069","display_name":"Tail flick test","level":4,"score":0.5798846483230591},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5428597331047058},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5349980592727661},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5119982361793518},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3938329815864563},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.256952702999115},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.15880176424980164},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08205708861351013},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002186","descriptor_name":"Cannabinoids","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D003511","descriptor_name":"Cyclohexanols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007278","descriptor_name":"Injections, Spinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016760","descriptor_name":"Proto-Oncogene Proteins c-fos","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11216448","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11216448","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo yao li xue bao = Acta pharmacologica Sinica","raw_type":"Comparative Study"},{"id":"mag:2403662924","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11216448","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1557060919","display_name":"NEUROLOGICAL BASIS OF PAIN: ROLE OF CANNABINOIDS","funder_award_id":"R01NS033247","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4391565154","display_name":"PRECIPITATED CANNABINOID WITHDRAWAL","funder_award_id":"R01DA010536","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G7627812292","display_name":"MARIJUANA WITHDRAWAL","funder_award_id":"K02DA000375","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2088607177","https://openalex.org/W1537638589","https://openalex.org/W2112862991","https://openalex.org/W2074851677","https://openalex.org/W2011727049","https://openalex.org/W2062301233","https://openalex.org/W1968642035","https://openalex.org/W1964670355","https://openalex.org/W2374649833","https://openalex.org/W2014072624"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"determine":[2],"whether":[3],"cannabinoids":[4],"suppress":[5,141],"noxious":[6],"stimulus-evoked":[7],"Fos":[8,82],"protein-like":[9],"immunoreactivity":[10],"(FLI)":[11],"through":[12,146],"direct":[13],"actions":[14,147],"at":[15,27,148],"the":[16,35,40,61,84,88,93,99,105,122,131,149],"spinal":[17,54,150,166],"level.":[18,151],"METHODS:":[19],"Rats":[20],"were":[21,56],"implanted":[22],"with":[23,58],"intrathecal":[24],"(ith)":[25],"catheters":[26],"least":[28],"one":[29],"week":[30],"prior":[31],"to":[32,118,136],"evaluation":[33],"in":[34,52,83,92,98,107,110,130,144,161],"formalin":[36,48],"test.":[37],"Effects":[38],"of":[39,60,87,104],"cannabinoid":[41,80,106],"agonist,":[42],"CP55,940":[43,69,160],"(80":[44],"micrograms":[45,67],"ith)":[46],"on":[47],"pain":[49,71,114],"and":[50,73,91,113,157],"FLI":[51,74,109,129,164],"rat":[53],"cord":[55],"compared":[57],"that":[59],"prototypic":[62],"narcotic":[63],"analgesic,":[64],"morphine":[65,119,127,153],"(20":[66],"ith).":[68],"suppressed":[70,81,128],"behavior":[72,115],"induced":[75],"by":[76],"intraplantar":[77],"formalin.":[78],"The":[79,102],"neck":[85],"region":[86],"dorsal":[89,133],"horn":[90,134],"ventral":[94],"horn,":[95],"but":[96],"not":[97],"nucleus":[100],"proprius.":[101],"efficacy":[103,158],"suppressing":[108,162],"these":[111],"laminae":[112],"was":[116],"comparable":[117],"administered":[120],"via":[121],"same":[123],"route.":[124],"However,":[125,152],"only":[126],"superficial":[132],"relative":[135],"vehicle":[137],"treatment.":[138],"CONCLUSION:":[139],"Cannabinoids":[140],"nociceptive":[142],"processing,":[143],"part,":[145],"showed":[154],"greater":[155],"potency":[156],"than":[159],"formalin-induced":[163],"following":[165],"administration.":[167]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
