{"id":"https://openalex.org/W2403662346","doi":null,"title":"Administration of elastase blocks the formation of fragmented elastic fibers in aorta of rabbit.","display_name":"Administration of elastase blocks the formation of fragmented elastic fibers in aorta of rabbit.","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2403662346","mag":"2403662346","pmid":"https://pubmed.ncbi.nlm.nih.gov/2803012"},"language":"en","primary_location":{"id":"pmid:2803012","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2803012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artery","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030756127","display_name":"Toshiro Ooyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152580","display_name":"Tokyo Metropolitan Geriatric Hospital","ror":"https://ror.org/04emv5a43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210152580"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Ooyama","raw_affiliation_strings":["Division of Immunology, Tokyo Metropolitan Geriatric Medical Center, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Tokyo Metropolitan Geriatric Medical Center, Japan","institution_ids":["https://openalex.org/I4210152580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026407045","display_name":"Koji Fukuda","orcid":"https://orcid.org/0000-0002-1271-1796","observed_orcids":["https://orcid.org/0000-0002-1271-1796"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Fukuda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"S Masuda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Masuda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101440870","display_name":"Hiroki Nakamura","orcid":"https://orcid.org/0000-0002-1039-7246","observed_orcids":["https://orcid.org/0000-0002-1039-7246"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Nakamura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2995,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.50871566,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"16","issue":"6","first_page":"293","last_page":"311"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.5365999937057495,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.5365999937057495,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12924","display_name":"Dermatological and Skeletal Disorders","score":0.19580000638961792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.07150000333786011,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/elastase","display_name":"elastase","score":0.8960000276565552},{"id":"https://openalex.org/keywords/elastic-fiber-degradation","display_name":"elastic fiber degradation","score":0.6119999885559082},{"id":"https://openalex.org/keywords/aortic-media","display_name":"aortic media","score":0.6690000295639038},{"id":"https://openalex.org/keywords/elastin-derived-peptides","display_name":"elastin peptides","score":0.902999997138977},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7519999742507935},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.35899999737739563}],"concepts":[{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.9465996026992798},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.7866636514663696},{"id":"https://openalex.org/C2780028357","wikidata":"https://www.wikidata.org/wiki/Q259817","display_name":"Elastic fiber","level":2,"score":0.7760465145111084},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.6629592776298523},{"id":"https://openalex.org/C2776326425","wikidata":"https://www.wikidata.org/wiki/Q976747","display_name":"Pancreatic elastase","level":4,"score":0.5328778624534607},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5227630138397217},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.492033451795578},{"id":"https://openalex.org/C2776864027","wikidata":"https://www.wikidata.org/wiki/Q615993","display_name":"Thoracic aorta","level":3,"score":0.4608151316642761},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4293716549873352},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4266052544116974},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38159847259521484},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3723108470439911},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34853318333625793},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3086129426956177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17472553253173828},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1712045669555664},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07520946860313416},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001013","descriptor_name":"Aorta, Thoracic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001013","descriptor_name":"Aorta, Thoracic","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001018","descriptor_name":"Aortic Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001018","descriptor_name":"Aortic Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004549","descriptor_name":"Elastin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010196","descriptor_name":"Pancreatic Elastase","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2803012","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2803012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artery","raw_type":"Journal Article"},{"id":"mag:2403662346","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2803012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2047194708","https://openalex.org/W2606338221","https://openalex.org/W7100819837","https://openalex.org/W1979878255","https://openalex.org/W2605804277","https://openalex.org/W2035389299","https://openalex.org/W2607298850","https://openalex.org/W2061069208","https://openalex.org/W2051283670","https://openalex.org/W2605948015"],"abstract_inverted_index":{"Fragmented":[0,34],"elastic":[1,22,35,52,96,106,126],"fibers":[2,23,36,53,97,107,127],"are":[3],"known":[4],"to":[5],"be":[6],"associated":[7,41],"with":[8,31,42,89],"atherosclerotic":[9],"lesions,":[10],"angitis":[11],"and":[12,47,101],"age-related":[13,64],"changes":[14,65],"of":[15,50,66,75,81,93,104,110,124],"the":[16,25,38,48,55,67,73,79,102,105,116,122,129],"vessel":[17,68],"wall.":[18,69,131],"We":[19,70],"produced":[20],"fragmented":[21,95,125],"in":[24,37,128],"thoracic":[26],"aorta":[27],"by":[28],"immunizing":[29],"rabbits":[30,85],"elastin":[32,87],"peptides.":[33],"media":[39],"were":[40,98],"degenerative":[43],"smooth":[44],"muscle":[45],"cells,":[46],"number":[49],"fine":[51],"beneath":[54],"endothelium":[56],"was":[57],"decreased.":[58],"The":[59],"lesion":[60],"presented":[61],"here":[62],"resembled":[63,108],"also":[71],"evaluated":[72],"influence":[74],"elastase":[76,120],"administration":[77,92],"on":[78],"formation":[80,123],"this":[82],"lesion.":[83],"In":[84],"receiving":[86],"immunization":[88],"simultaneous":[90],"intraperitoneal":[91],"elastase,":[94],"apparently":[99],"decreased":[100],"appearance":[103],"that":[109,118],"normal":[111],"rabbits.":[112],"These":[113],"data":[114],"suggest":[115],"possibility":[117],"administered":[119],"blocks":[121],"aortic":[130]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}