{"id":"https://openalex.org/W2403636480","doi":null,"title":"Pediatric phase I trial of carboplatin: a Childrens Cancer Study Group report.","display_name":"Pediatric phase I trial of carboplatin: a Childrens Cancer Study Group report.","publication_year":1987,"publication_date":"1987-11-01","ids":{"openalex":"https://openalex.org/W2403636480","mag":"2403636480","pmid":"https://pubmed.ncbi.nlm.nih.gov/3315195"},"language":"en","primary_location":{"id":"pmid:3315195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3315195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer treatment reports","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083151898","display_name":"Gaynon Ps","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136340","display_name":"Comer Children's Hospital","ror":"https://ror.org/02y96rp12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210136340"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P S Gaynon","raw_affiliation_strings":["Wyler Children's Hospital, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wyler Children's Hospital, IL","institution_ids":["https://openalex.org/I4210136340"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060182152","display_name":"Ettinger Lj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L J Ettinger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090658378","display_name":"Donald I. Moel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Moel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052898750","display_name":"S E Siegel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S E Siegel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029567709","display_name":"Edward S. Baum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E S Baum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047077103","display_name":"William A. Krivit","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Krivit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035309850","display_name":"Hammond Gd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G D Hammond","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4647,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.60077014,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"71","issue":"11","first_page":"1039","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.3244999945163727,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.3244999945163727,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.24060000479221344,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.21789999306201935,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":1.0},{"id":"https://openalex.org/keywords/cisplatin-analogues","display_name":"cisplatin analogues","score":0.9419999718666077},{"id":"https://openalex.org/keywords/pediatric-chemotherapy","display_name":"pediatric chemotherapy","score":0.7160000205039978},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.7979999780654907},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.8080000281333923},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hypomagnesemia","display_name":"hypomagnesemia","score":0.8040000200271606},{"id":"https://openalex.org/keywords/hypocalcemia","display_name":"hypocalcemia","score":0.9769999980926514},{"id":"https://openalex.org/keywords/ototoxicity","display_name":"ototoxicity","score":0.9940000176429749},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.6639999747276306},{"id":"https://openalex.org/keywords/ependymoma","display_name":"ependymoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/brainstem-glioma","display_name":"brainstem glioma","score":0.9269999861717224},{"id":"https://openalex.org/keywords/spinal-cord-astrocytoma","display_name":"spinal cord astrocytoma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/recommended-phase-ii-dose","display_name":"recommended phase 2 dose","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9623976945877075},{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.7775391340255737},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.6397305727005005},{"id":"https://openalex.org/C2776183862","wikidata":"https://www.wikidata.org/wiki/Q3771629","display_name":"Hypomagnesemia","level":3,"score":0.5805001854896545},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.5740998387336731},{"id":"https://openalex.org/C2781432949","wikidata":"https://www.wikidata.org/wiki/Q1346753","display_name":"Ependymoma","level":2,"score":0.5335413217544556},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.5114656686782837},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4774497151374817},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.47655656933784485},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.46220943331718445},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.45845383405685425},{"id":"https://openalex.org/C2778534666","wikidata":"https://www.wikidata.org/wiki/Q1351381","display_name":"Ototoxicity","level":4,"score":0.42569804191589355},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4186432957649231},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.40018129348754883},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3353493809700012},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.24603024125099182},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0},{"id":"https://openalex.org/C543218039","wikidata":"https://www.wikidata.org/wiki/Q660","display_name":"Magnesium","level":2,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004341","descriptor_name":"Drug Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3315195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3315195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer treatment reports","raw_type":"Journal Article"},{"id":"mag:2403636480","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3315195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2227545313","https://openalex.org/W2418854645","https://openalex.org/W1986914074","https://openalex.org/W1997199448","https://openalex.org/W2074535370","https://openalex.org/W1980560578","https://openalex.org/W1906991996","https://openalex.org/W1906057952","https://openalex.org/W2241042427","https://openalex.org/W2015198087"],"abstract_inverted_index":{"Carboplatin":[0],"is":[1,207],"one":[2,190],"of":[3,6,25,84,105,110,122,163],"a":[4,23,61,103,160,168,212],"series":[5],"cisplatin":[7],"analogs":[8],"now":[9],"undergoing":[10],"clinical":[11],"investigation.":[12],"Phase":[13],"I":[14,41],"and":[15,28,51,87,97,146,151,153,197],"II":[16,55,114,205],"trials":[17],"in":[18,22,57,77,91,120,187],"adults":[19],"demonstrate":[20],"activity":[21],"number":[24],"human":[26],"cancers":[27],"less":[29],"toxicity":[30],"than":[31,179],"might":[32],"be":[33],"expected":[34],"with":[35,70,102,159,192],"the":[36,47,52,81,111,118,164],"parent":[37],"compound.":[38],"This":[39],"phase":[40,54,113,204],"trial":[42],"was":[43,129,185],"undertaken":[44],"to":[45,124,182],"establish":[46],"maximum":[48],"tolerated":[49],"dose":[50,56,104,119,206],"recommended":[53,202],"children":[58],"treated":[59],"by":[60],"1-hour":[62,213],"iv":[63,214],"infusion":[64,215],"every":[65,216],"4":[66,217],"weeks.":[67,218],"Twenty-nine":[68],"patients":[69,123],"recurrent":[71],"or":[72,180],"progressive":[73],"tumor":[74],"were":[75,148,155],"entered":[76],"this":[78,132],"study":[79],"at":[80,131,137],"Children's":[82,88],"Hospital":[83,90],"Los":[85],"Angeles":[86],"Memorial":[89],"Chicago":[92],"between":[93],"April":[94],"12,":[95],"1983,":[96],"November":[98],"27,":[99],"1984.":[100],"Beginning":[101],"350":[106],"mg/m2":[107,209],"(about":[108],"80%":[109],"adult":[112],"dose),":[115],"we":[116],"escalated":[117],"groups":[121],"670":[125],"mg/m2;":[126],"dose-limiting":[127],"myelosuppression":[128],"encountered":[130],"dose.":[133],"Fifty-seven":[134],"infusions":[135],"are":[136],"least":[138],"partially":[139],"evaluable":[140],"for":[141,177],"toxicity.":[142],"Asymptomatic":[143],"hypomagnesemia,":[144],"hypocalcemia,":[145],"ototoxicity":[147],"observed":[149,186],"infrequently,":[150],"nausea":[152],"vomiting":[154],"mild.":[156],"One":[157],"patient":[158],"mixed":[161],"glioma":[162],"posterior":[165],"fossa":[166],"achieved":[167],"good":[169],"partial":[170],"response":[171],"lasting":[172],"9":[173],"months.":[174],"Stable":[175],"disease":[176],"greater":[178],"equal":[181],"6":[183],"months":[184],"three":[188],"patients:":[189],"each":[191],"ependymoma,":[193],"brain":[194],"stem":[195],"glioma,":[196],"spinal":[198],"cord":[199],"astrocytoma.":[200],"The":[201],"pediatric":[203],"560":[208],"given":[210],"as":[211]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}