{"id":"https://openalex.org/W2403480345","doi":null,"title":"The combination of Steel factor and GM-CSF blocks apoptosis induced by retinoic acid and upregulates AP-1 in a human growth factor-dependent cell line.","display_name":"The combination of Steel factor and GM-CSF blocks apoptosis induced by retinoic acid and upregulates AP-1 in a human growth factor-dependent cell line.","publication_year":1995,"publication_date":"1995-02-01","ids":{"openalex":"https://openalex.org/W2403480345","mag":"2403480345","pmid":"https://pubmed.ncbi.nlm.nih.gov/7530213"},"language":"en","primary_location":{"id":"pmid:7530213","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7530213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental hematology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M Horie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Horie","raw_affiliation_strings":["Department of Medicine (Hematology/Oncology), Indiana University School of Medicine, Indianapolis 46202-5121"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Hematology/Oncology), Indiana University School of Medicine, Indianapolis 46202-5121","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038161052","display_name":"Hal E. Broxmeyer","orcid":"https://orcid.org/0000-0001-6575-0476","observed_orcids":["https://orcid.org/0000-0001-6575-0476"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H E Broxmeyer","raw_affiliation_strings":["Microbiology & Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology & Immunology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6225,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.64612132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"23","issue":"2","first_page":"168","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stem-cell-factor","display_name":"stem cell factor","score":0.8339999914169312},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.8889999985694885},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.9919999837875366},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/ap-1","display_name":"AP-1","score":0.7490000128746033},{"id":"https://openalex.org/keywords/mo7e-cells","display_name":"MO7e cells","score":0.7379999756813049},{"id":"https://openalex.org/keywords/hematopoietic-growth-factors","display_name":"hematopoietic growth factors","score":0.9399999976158142},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/raralpha","display_name":"RAR\u03b1","score":0.8159999847412109},{"id":"https://openalex.org/keywords/receptor-signaling-pathways","display_name":"receptor signaling pathways","score":0.46000000834465027},{"id":"https://openalex.org/keywords/cytokine-synergy","display_name":"cytokine synergy","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6905215978622437},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.6556646227836609},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.6062300801277161},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5955646634101868},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.563141942024231},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5619537234306335},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5418620109558105},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5303894877433777},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49694517254829407},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.46184414625167847},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.4287243187427521},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.42520639300346375},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3612978458404541},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3468422293663025},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3242976665496826},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16697406768798828},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11998742818832397},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.109182208776474},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06966787576675415}],"mesh":[{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016298","descriptor_name":"Hematopoietic Cell Growth Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019089","descriptor_name":"Stem Cell Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7530213","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7530213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental hematology","raw_type":"Journal Article"},{"id":"mag:2403480345","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7530213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5097623640","display_name":"CSF MGF FUSION PROTEINS AND MYELOPOIESIS","funder_award_id":"R37CA036464","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5532857528","display_name":"MYELOID REGULATION BY GROWTH SUPPRESSING CYTOKINES","funder_award_id":"R01HL049202","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8337518668","display_name":"UMBILICAL CORD BLOOD STEM CELLS AND IMMUNOLOGY","funder_award_id":"R01HL046549","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2049497785","https://openalex.org/W1976356817","https://openalex.org/W2408760195","https://openalex.org/W39054529","https://openalex.org/W2087045958","https://openalex.org/W33796258","https://openalex.org/W2588441644","https://openalex.org/W2429730385","https://openalex.org/W2059372258","https://openalex.org/W2129968713"],"abstract_inverted_index":{"The":[0],"effects":[1,106],"of":[2,12,24,54,61,78,104,118,120,129,162,184],"hematopoietic":[3],"growth":[4],"factors":[5],"were":[6,88],"examined":[7],"on":[8,107],"the":[9,17,52,76,102,160,191],"cellular":[10],"action":[11],"retinoic":[13],"acid":[14],"(RA)":[15],"using":[16],"human":[18],"factor-dependent":[19],"cell":[20,37,68],"line,":[21],"MO7e.":[22],"Treatment":[23,60],"cells":[25,62,93,109,145,167],"with":[26,42,63,71,94,147,155,169,190],"Steel":[27],"factor":[28,33,44,157],"(SLF)":[29],"plus":[30,96,112,149],"granulocyte-macrophage":[31],"colony-stimulating":[32],"(GM-CSF)":[34],"synergistically":[35],"stimulated":[36],"proliferation":[38],"compared":[39,151],"to":[40,152],"that":[41,101,186],"each":[43,156],"alone.":[45],"This":[46],"synergism":[47],"was":[48,132],"even":[49],"greater":[50],"in":[51,57,66,75,139,166,178],"presence":[53,77],"RA":[55,64,105,121],"than":[56],"its":[58],"absence.":[59],"resulted":[65],"apoptotic":[67],"death":[69],"associated":[70,189],"internucleosomal":[72],"DNA":[73,86],"fragmentation":[74,87],"either":[79],"SLF":[80,95,111,148,170],"or":[81],"GM-CSF.":[82,97,172],"RA-induced":[83],"apoptosis":[84],"and":[85],"completely":[89],"blocked":[90],"by":[91,110,134],"treating":[92],"Northern":[98],"analysis":[99],"showed":[100],"inhibition":[103],"MO7e":[108],"GM-CSF":[113,150],"treatment":[114],"occurred":[115],"without":[116],"modulation":[117],"expression":[119],"receptor-alpha":[122],"(RAR-alpha)":[123],"gene.":[124],"Furthermore,":[125],"a":[126,140],"higher":[127],"amount":[128],"AP-1":[130,192],"complex":[131],"detected":[133],"electrophoretic":[135],"mobility":[136],"shift":[137],"assays":[138],"nuclear":[141],"extract":[142],"prepared":[143],"from":[144],"treated":[146,154,168],"those":[153],"alone,":[158],"while":[159],"level":[161],"RAR-complex":[163],"remained":[164],"similar":[165],"and/or":[171],"These":[173],"data":[174],"suggest":[175],"an":[176],"interaction":[177],"signaling":[179],"pathways":[180],"among":[181],"different":[182],"types":[183],"receptors":[185],"might":[187],"be":[188],"complex.":[193]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}