{"id":"https://openalex.org/W2403465077","doi":null,"title":"Preferential DNA repair in active genes.","display_name":"Preferential DNA repair in active genes.","publication_year":1987,"publication_date":"1987-12-01","ids":{"openalex":"https://openalex.org/W2403465077","mag":"2403465077","pmid":"https://pubmed.ncbi.nlm.nih.gov/3325235"},"language":"en","primary_location":{"id":"pmid:3325235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3325235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Danish medical bulletin","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089917586","display_name":"Vilhelm A. Bohr","orcid":"https://orcid.org/0000-0003-4823-6429","observed_orcids":["https://orcid.org/0000-0003-4823-6429"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"V A Bohr","raw_affiliation_strings":["National Cancer Institute, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Bethesda, MD 20892","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089917586"],"corresponding_institution_ids":["https://openalex.org/I4210140884"],"apc_list":null,"apc_paid":null,"fwci":0.5801,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.60462365,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"34","issue":"6","first_page":"309","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uv-induced-dna-damage","display_name":"UV-induced DNA damage","score":0.843999981880188},{"id":"https://openalex.org/keywords/essential-genes","display_name":"essential genes","score":0.7009999752044678},{"id":"https://openalex.org/keywords/xpc-gene","display_name":"XPC gene","score":0.5609999895095825},{"id":"https://openalex.org/keywords/dihydrofolate-reductase-gene","display_name":"dihydrofolate reductase gene","score":0.8220000267028809},{"id":"https://openalex.org/keywords/uv-resistance","display_name":"UV resistance","score":0.7680000066757202},{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.9369999766349792},{"id":"https://openalex.org/keywords/chromatin-looping","display_name":"chromatin looping","score":0.6399999856948853},{"id":"https://openalex.org/keywords/dna-repair-regulation","display_name":"DNA repair regulation","score":0.6489999890327454},{"id":"https://openalex.org/keywords/cho-cells","display_name":"CHO cells","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.8159770369529724},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7192226648330688},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.7015108466148376},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.6368276476860046},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.621086061000824},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6205095648765564},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.598372220993042},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.513645589351654},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.490092396736145},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.47704261541366577},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36893022060394287}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011740","descriptor_name":"Pyrimidine Dimers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:3325235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3325235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Danish medical bulletin","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2091997664","https://openalex.org/W198299714","https://openalex.org/W1981380587","https://openalex.org/W1984353960","https://openalex.org/W1981900473","https://openalex.org/W2007531486","https://openalex.org/W2177581130","https://openalex.org/W2003069665","https://openalex.org/W2045868105","https://openalex.org/W2067984194"],"abstract_inverted_index":{"We":[0,155,274,294,376],"have":[1,80,130,156,224,275,377],"demonstrated":[2,220],"that":[3,43,82,183,226,255,261,348],"essential":[4,238],"genes":[5,24,83,387],"in":[6,10,112,125,162,188,221,231,250,266,285,291,306,321,344,352,381],"rodent":[7,21],"cells":[8,13,64,233],"and":[9,120,166,176,258,286,320,333,346,362],"normal":[11,76,177],"human":[12,61,77,268],"are":[14,25,84,101],"preferentially":[15,228],"repaired":[16,26,85,229],"after":[17],"UV":[18,52,167,212],"damage.":[19,213],"In":[20,75],"cells,":[22,78],"some":[23],"much":[27],"more":[28,194],"efficiently":[29,68],"than":[30,87,150,196],"the":[31,34,39,88,91,144,153,163,227,237,248,267,278,288,314,318,370,382,389],"bulk":[32,89],"of":[33,72,90,106,152,185,282,298,302,317,340,358,372,385],"genome.":[35,154],"This":[36,326],"may":[37,192,243],"explain":[38],"long":[40],"standing":[41],"paradox":[42],"their":[44,51],"overall":[45,116,139,158,197],"genome":[46,140,159,249],"repair":[47,67,109,118,128,141,161,187,199,216,242,270,284,301,311,350,383],"is":[48,54,264],"low,":[49],"but":[50,93],"survival":[53],"as":[55,57,209],"high":[56],"for":[58,169,201,256,336,369],"proficiently":[59,102],"repairing":[60],"cells.":[62,293],"Rodent":[63],"appear":[65],"to":[66,203,211,254],"only":[69,147],"genomic":[70,99,190,279,353],"regions":[71,100,146,230,354],"vital":[73,145],"importance.":[74],"we":[79,223,259],"found":[81,225,378],"faster":[86],"genome,":[92],"eventually":[94],"(after":[95],"24":[96],"hrs)":[97],"all":[98],"repaired.":[103],"The":[104,179],"demonstration":[105],"preferential":[107,126,299],"DNA":[108,117,127,186,198,215,241,269,283,300,310,349],"mandates":[110],"caution":[111],"interpreting":[113],"correlations":[114,202],"between":[115],"capacity":[119],"other":[121,204],"biological":[122,205],"parameters.":[123],"Changes":[124],"could":[129],"profound":[131],"effects":[132],"on":[133],"such":[134,208],"parameters":[135],"without":[136],"noticeably":[137],"altering":[138],"levels":[142],"since":[143],"constitute":[148],"less":[149],"1%":[151],"correlated":[157],"repair,":[160],"DHFR":[164,239,289],"gene,":[165],"resistance":[168,210],"three":[170],"different":[171,386],"cell":[172],"lines:":[173],"CHO,":[174],"XPC":[175],"human.":[178],"results":[180],"further":[181],"suggest":[182],"determinations":[184],"specific":[189],"sequences":[191],"be":[193,245],"important":[195],"measurements":[200],"end":[206,316],"points":[207],"Although":[214],"heterogeneity":[217],"has":[218],"been":[219],"XPC,":[222],"these":[232],"do":[234],"not":[235],"include":[236],"gene.":[240],"normally":[244],"regulated":[246],"over":[247],"a":[251,296,367],"similar":[252],"manner":[253],"transcription,":[257],"propose":[260],"this":[262],"regulation":[263],"deficient":[265,271],"syndrome":[272],"XPC.":[273],"also":[276],"analyzed":[277],"fine":[280],"structure":[281,343],"around":[287],"gene":[290,319],"CHO":[292],"find":[295],"region":[297],"approximately":[303],"60-80":[304],"kb":[305],"length":[307],"with":[308,331,366],"maximal":[309],"efficiency":[312,351,384],"at":[313],"5'":[315,323],"its":[322],"flanking":[324],"sequences.":[325],"size":[327],"corresponds":[328],"very":[329],"well":[330],"proposed":[332],"measured":[334],"lengths":[335],"loops":[337],"or":[338],"domains":[339],"higher":[341],"order":[342],"chromatin,":[345],"suggests":[347],"might":[355],"reflect":[356],"aspects":[357],"local":[359],"chromatin":[360,373],"structure,":[361],"thus":[363],"provide":[364],"us":[365],"probe":[368],"detection":[371],"structural":[374],"changes.":[375],"considerable":[379],"differences":[380],"within":[388],"same":[390],"cell.(ABSTRACT":[391],"TRUNCATED":[392],"AT":[393],"400":[394],"WORDS)":[395]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}