{"id":"https://openalex.org/W2403400575","doi":null,"title":"Caract\u00e9risation du domaine de liaison des r\u00e9cepteurs de l'endoth\u00e9line \u00e0 l'aide de sondes photor\u00e9actives","display_name":"Caract\u00e9risation du domaine de liaison des r\u00e9cepteurs de l'endoth\u00e9line \u00e0 l'aide de sondes photor\u00e9actives","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2403400575","mag":"2403400575"},"language":"fr","primary_location":{"id":"pmh:oai:espace.inrs.ca:126","doi":null,"is_oa":false,"landing_page_url":"https://espace.inrs.ca/id/eprint/126/1/Aubin%2C_Jacinthe.pdf","pdf_url":"https://espace.inrs.ca/id/eprint/126/1/Aubin%2C_Jacinthe.pdf","source":{"id":"https://openalex.org/S4306400579","display_name":"EspaceINRS (National Institute for Scientific Research (Canada))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I39481719","host_organization_name":"Institut National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I39481719"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Th\u00e8se"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111581469","display_name":"Jacinthe Aubin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jacinthe Aubin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111581469"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.060499999672174454,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelin","display_name":"endothelin","score":0.8069999814033508},{"id":"https://openalex.org/keywords/endothelin-receptors","display_name":"endothelin receptors","score":0.8880000114440918},{"id":"https://openalex.org/keywords/endothelin-a-receptor","display_name":"ETA receptor","score":0.722000002861023},{"id":"https://openalex.org/keywords/endothelin-b-receptor","display_name":"endothelin B receptor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/receptor-binding-sites","display_name":"receptor binding sites","score":0.546999990940094},{"id":"https://openalex.org/keywords/photoreactive-probes","display_name":"photoreactive probes","score":0.8220000267028809},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.6579999923706055},{"id":"https://openalex.org/keywords/receptor-antagonists","display_name":"receptor antagonists","score":0.4740000069141388},{"id":"https://openalex.org/keywords/receptor-agonists","display_name":"receptor agonists","score":0.8980000019073486},{"id":"https://openalex.org/keywords/vasoconstriction","display_name":"vasoconstriction","score":0.7559999823570251},{"id":"https://openalex.org/keywords/vascular-tone","display_name":"vascular tone","score":0.6010000109672546},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7269999980926514},{"id":"https://openalex.org/keywords/ischemia","display_name":"ischemia","score":0.7289999723434448},{"id":"https://openalex.org/keywords/rat-aorta","display_name":"rat aorta","score":0.722000002861023},{"id":"https://openalex.org/keywords/guinea-pig-lung","display_name":"guinea pig lung","score":0.8429999947547913},{"id":"https://openalex.org/keywords/receptor-ligand-complex","display_name":"receptor-ligand complex","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33123254776000977}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:espace.inrs.ca:126","doi":null,"is_oa":false,"landing_page_url":"https://espace.inrs.ca/id/eprint/126/1/Aubin%2C_Jacinthe.pdf","pdf_url":"https://espace.inrs.ca/id/eprint/126/1/Aubin%2C_Jacinthe.pdf","source":{"id":"https://openalex.org/S4306400579","display_name":"EspaceINRS (National Institute for Scientific Research (Canada))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I39481719","host_organization_name":"Institut National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I39481719"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Th\u00e8se"},{"id":"mag:2403400575","doi":null,"is_oa":false,"landing_page_url":"http://espace.inrs.ca/126/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2338109193","https://openalex.org/W2337482320","https://openalex.org/W7037046755","https://openalex.org/W2610534106","https://openalex.org/W2346248939","https://openalex.org/W425013058","https://openalex.org/W2610046498","https://openalex.org/W7009243550","https://openalex.org/W2609561767","https://openalex.org/W4253542160"],"abstract_inverted_index":{"La":[0,25,350],"transcription":[1],"des":[2,5,39,126,130,147,177,228,261,265,271,291,298,303,352],"symboles":[3],"et":[4,77,87,93,100,116,144,162,172,196,214,235,274,322,326,337],"caract\u00e8res":[6],"sp\u00e9ciaux":[7],"utilis\u00e9s":[8],"dans":[9,57,64,138],"la":[10,65,164,209,220,362,373,377,382,398,402,424],"version":[11,26],"originale":[12],"de":[13,22,28,54,73,97,106,111,120,124,128,132,149,190,192,204,237,254,267,279,287,300,348,359,370,376,401,415,440],"ce":[14,29,45,114,327],"r\u00e9sum\u00e9":[15,30],"n\u2019a":[16],"pas":[17],"\u00e9t\u00e9":[18,48,136,240,258,294,343],"possible":[19],"en":[20,34],"raison":[21],"limitations":[23],"techniques.":[24],"correcte":[27],"peut":[31],"\u00eatre":[32],"lue":[33],"PDF.":[35],"\\n":[36],"\\nL'endoth\u00e9line,":[37],"un":[38,83,142,145,250,368,408],"plus":[40,53],"puissants":[41],"vasoconstricteur":[42],"connus":[43],"\u00e0":[44,432],"jour":[46],"a":[47,52,186,257,293,356],"d\u00e9couvert":[49],"il":[50,102],"y":[51],"20":[55],"ans":[56],"les":[58,109,202,307,320,346,419],"cellules":[59,304],"endoth\u00e9liales.":[60],"Il":[61],"est":[62,103],"impliqu\u00e9":[63],"r\u00e9gulation":[66],"du":[67,182,330,385,395,428,434],"tonus":[68],"vasculaire":[69],"via":[70],"deux":[71],"types":[72],"r\u00e9cepteurs,":[74],"soit":[75,223,333],"ETA":[76,309],"ETB.":[78,311],"Diff\u00e9rentes":[79],"\u00e9tudes":[80,131,347],"ont":[81,239,342,421],"montr\u00e9":[82,422],"lien":[84,167],"entre":[85,113,169,194],"l'ET":[86,195,238],"certaines":[88],"maladies":[89],"vasculaires,":[90],"telles":[91],"l'hypertension":[92],"l'isch\u00e9mie.":[94],"Du":[95],"point":[96,369,409],"vue":[98],"pharmacologique":[99],"th\u00e9rapeutique,":[101],"donc":[104],"important":[105],"mieux":[107,200],"comprendre":[108],"m\u00e9canismes":[110],"liaison":[112,125],"peptide":[115],"ses":[117,197],"r\u00e9cepteurs.":[118,198],"Afin":[119],"caract\u00e9riser":[121],"le":[122,173,244,247,276,392],"domaine":[123,386],"r\u00e9cepteur":[127,185,429],"ET,":[129],"photomarquage":[133],"avaient":[134],"d\u00e9j\u00e0":[135],"effectu\u00e9es":[137],"notre":[139],"laboratoire,":[140],"avec":[141,219],"antagoniste":[143],"agoniste":[146],"r\u00e9cepteurs":[148,161,272,288,308,321,355],"l'ET.":[150,224],"Cette":[151],"technique":[152,211],"se":[153],"base":[154],"sur":[155,163,264,275,302,372],"l'affinit\u00e9":[156],"d'une":[157],"sonde":[158,171,363],"photor\u00e9active":[159],"aux":[160],"formation":[165],"d'un":[166],"covalent":[168],"cette":[170,217],"r\u00e9cepteur.":[174],"L'analyse":[175],"\u00e9lectrophor\u00e9tique":[176],"fragments":[178],"obtenus":[179],"apr\u00e8s":[180],"clivage":[181],"complexe":[183],"ligand\u00ad":[184,354],"ainsi":[187,357],"permis":[188,358],"l'identification":[189],"points":[191],"contact":[193,371],"Pour":[199],"cibler":[201],"sites":[203],"liaison,":[205],"nous":[206],"avons":[207],"utilis\u00e9":[208],"m\u00eame":[210],"qu'avec":[212],"l'antagoniste":[213],"l'agoniste,":[215],"mais":[216],"fois":[218],"mol\u00e9cule":[221],"endog\u00e8ne,":[222],"Les":[225,312],"acides":[226],"amin\u00e9s":[227],"positions":[229],"4,":[230],"7,":[231],"9,":[232],"12,":[233],"14":[234],"21":[236],"successivement":[241],"remplac\u00e9s":[242],"par":[243,260,297],"L-":[245],"ou":[246,310,381,397],"D-p-benzoylphenylalanine":[248],"(p-Bpa),":[249],"agent":[251],"photosensible.":[252],"L'activit\u00e9":[253],"ces":[255],"analogues":[256,292],"v\u00e9rifi\u00e9e":[259,296],"essais":[262],"pharmacologiques":[263],"aortes":[266],"rat":[268],"(contenant":[269,281],"essentiellement":[270],"ETA)":[273],"parenchyme":[277],"pulmonaire":[278],"cobaye":[280],"une":[282,316,323],"population":[283],"majoritaire":[284],"(environ":[285],"80%)":[286],"ETB).":[289],"L'affinit\u00e9":[290],"ensuite":[295],"tests":[299],"comp\u00e9tition":[301],"CHO":[305],"surexprimant":[306],"sondes":[313],"ayant":[314],"conserv\u00e9":[315],"bonne":[317,324],"\\naffinit\u00e9":[318],"pour":[319,345],"activit\u00e9":[325],"malgr\u00e9":[328],"l'insertion":[329],"groupement":[331],"photoactivable,":[332],"[L-Bpa7,":[334],"Tyrct":[335],"251)13]hET-l)":[336],"[Nle7":[338],"L-Bpa":[339,365],"12,Tyrct":[340],"251)13]hET-1,":[341],"choisies":[344],"photomarquage.":[349],"digestion":[351],"complexes":[353],"d\u00e9terminer":[360],"que":[361,391,423],"[Nle7,":[364,436],"12]hET-l":[366],"aurait":[367],"deuxi\u00e8me":[374],"moiti\u00e9":[375,400],"1\u00e8re":[378],"boucle":[379,403,426],"extracellulaire":[380,427],"partie":[383],"sup\u00e9rieur":[384],"transmembranaire":[387],"III":[388,405],"(TMIII),":[389],"alors":[390],"segment":[393],"inf\u00e9rieur":[394],"TMVI":[396],"seconde":[399],"intracellulaire":[404],"(ECIII)":[406],"contiendrait":[407],"d'ancrage":[410],"\\npour":[411],"[L-Bpa7]hET-1":[412],"au":[413],"niveau":[414],"ETA.":[416],"De":[417],"plus,":[418],"travaux":[420],"2e":[425],"ET8":[430],"viendrait":[431],"proximit\u00e9":[433],"ligand":[435],"L\u00ad":[437],"Bpa12,Tyre25I)]hET-1":[438],"lors":[439],"sa":[441],"liaison.":[442]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
