{"id":"https://openalex.org/W2403371343","doi":"https://doi.org/10.1097/jcp.0000000000000319","title":"The Influence of the CYP3A4*22 Polymorphism and CYP2D6 Polymorphisms on Serum Concentrations of Aripiprazole, Haloperidol, Pimozide, and Risperidone in Psychiatric Patients","display_name":"The Influence of the CYP3A4*22 Polymorphism and CYP2D6 Polymorphisms on Serum Concentrations of Aripiprazole, Haloperidol, Pimozide, and Risperidone in Psychiatric Patients","publication_year":2015,"publication_date":"2015-04-11","ids":{"openalex":"https://openalex.org/W2403371343","doi":"https://doi.org/10.1097/jcp.0000000000000319","mag":"2403371343","pmid":"https://pubmed.ncbi.nlm.nih.gov/25868121"},"language":"en","primary_location":{"id":"doi:10.1097/jcp.0000000000000319","doi":"https://doi.org/10.1097/jcp.0000000000000319","is_oa":false,"landing_page_url":"https://doi.org/10.1097/jcp.0000000000000319","pdf_url":null,"source":{"id":"https://openalex.org/S76849566","display_name":"Journal of Clinical Psychopharmacology","issn_l":"0271-0749","issn":["0271-0749","1533-712X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059620488","display_name":"Karen van der Weide","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102758","display_name":"GGz centraal","ror":"https://ror.org/01m0gv380","country_code":"NL","type":"other","lineage":["https://openalex.org/I4210102758"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Karen van der Weide","raw_affiliation_strings":["From the *Department of Clinical Chemistry, St Jansdal Hospital, Harderwijk; and \u2020GGz Centraal, Veldwijk, Ermelo, The Netherlands","Department of Clinical Chemistry, St Jansdal Hospital, Harderwijk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the *Department of Clinical Chemistry, St Jansdal Hospital, Harderwijk; and \u2020GGz Centraal, Veldwijk, Ermelo, The Netherlands","institution_ids":["https://openalex.org/I4210102758"]},{"raw_affiliation_string":"Department of Clinical Chemistry, St Jansdal Hospital, Harderwijk","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017319285","display_name":"Jan van der Weide","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102758","display_name":"GGz centraal","ror":"https://ror.org/01m0gv380","country_code":"NL","type":"other","lineage":["https://openalex.org/I4210102758"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Jan van der Weide","raw_affiliation_strings":["Department of Clinical Chemistry, St Jansdal Hospital, Harderwijk","GGz Centraal, Veldwijk, Ermelo, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, St Jansdal Hospital, Harderwijk","institution_ids":[]},{"raw_affiliation_string":"GGz Centraal, Veldwijk, Ermelo, The Netherlands","institution_ids":["https://openalex.org/I4210102758"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017319285","https://openalex.org/A5059620488"],"corresponding_institution_ids":["https://openalex.org/I4210102758"],"apc_list":null,"apc_paid":null,"fwci":5.8473,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.97655464,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"35","issue":"3","first_page":"228","last_page":"236"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp2d6-polymorphism","display_name":"CYP2D6 polymorphism","score":0.9480000138282776},{"id":"https://openalex.org/keywords/aripiprazole","display_name":"aripiprazole","score":0.9369999766349792},{"id":"https://openalex.org/keywords/haloperidol","display_name":"haloperidol","score":1.0},{"id":"https://openalex.org/keywords/pimozide","display_name":"pimozide","score":1.0},{"id":"https://openalex.org/keywords/risperidone","display_name":"risperidone","score":1.0},{"id":"https://openalex.org/keywords/antipsychotic-drugs","display_name":"antipsychotic drugs","score":0.9129999876022339},{"id":"https://openalex.org/keywords/serum-drug-levels","display_name":"serum drug concentration","score":0.7820000052452087},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.6949999928474426},{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.8550000190734863},{"id":"https://openalex.org/keywords/poor-metabolizers","display_name":"poor metabolizers","score":0.7960000038146973},{"id":"https://openalex.org/keywords/psychiatric-patients","display_name":"psychiatric patients","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C2780211496","wikidata":"https://www.wikidata.org/wiki/Q411188","display_name":"Aripiprazole","level":3,"score":0.8644921779632568},{"id":"https://openalex.org/C2780057945","wikidata":"https://www.wikidata.org/wiki/Q412443","display_name":"Risperidone","level":3,"score":0.7773512005805969},{"id":"https://openalex.org/C33664856","wikidata":"https://www.wikidata.org/wiki/Q3271142","display_name":"CYP2D6","level":4,"score":0.7664754390716553},{"id":"https://openalex.org/C2777845345","wikidata":"https://www.wikidata.org/wiki/Q144085","display_name":"Pimozide","level":4,"score":0.7367662191390991},{"id":"https://openalex.org/C2780948584","wikidata":"https://www.wikidata.org/wiki/Q251347","display_name":"Haloperidol","level":3,"score":0.6556571125984192},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5978209376335144},{"id":"https://openalex.org/C109650736","wikidata":"https://www.wikidata.org/wiki/Q424440","display_name":"CYP3A4","level":4,"score":0.5317655205726624},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5017774105072021},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.4810341000556946},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4582350552082062},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45316919684410095},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.43787044286727905},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39889296889305115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22569715976715088},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.17428135871887207},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1696453094482422},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11606791615486145},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.10471317172050476},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.10289552807807922},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.09417906403541565},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068180","descriptor_name":"Aripiprazole","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000068180","descriptor_name":"Aripiprazole","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006220","descriptor_name":"Haloperidol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006220","descriptor_name":"Haloperidol","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010868","descriptor_name":"Pimozide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010868","descriptor_name":"Pimozide","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D018967","descriptor_name":"Risperidone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018967","descriptor_name":"Risperidone","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019389","descriptor_name":"Cytochrome P-450 CYP2D6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/jcp.0000000000000319","doi":"https://doi.org/10.1097/jcp.0000000000000319","is_oa":false,"landing_page_url":"https://doi.org/10.1097/jcp.0000000000000319","pdf_url":null,"source":{"id":"https://openalex.org/S76849566","display_name":"Journal of Clinical Psychopharmacology","issn_l":"0271-0749","issn":["0271-0749","1533-712X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Psychopharmacology","raw_type":"journal-article"},{"id":"pmid:25868121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25868121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical psychopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W74495713","https://openalex.org/W1526592756","https://openalex.org/W1534280303","https://openalex.org/W1591367548","https://openalex.org/W1607765060","https://openalex.org/W1849830234","https://openalex.org/W1876387579","https://openalex.org/W1912531397","https://openalex.org/W1964142218","https://openalex.org/W1970985273","https://openalex.org/W1974342102","https://openalex.org/W1976424662","https://openalex.org/W1977560862","https://openalex.org/W1983283139","https://openalex.org/W1989348141","https://openalex.org/W2002923710","https://openalex.org/W2004367469","https://openalex.org/W2015351193","https://openalex.org/W2021775978","https://openalex.org/W2024912502","https://openalex.org/W2031155689","https://openalex.org/W2032584539","https://openalex.org/W2037359408","https://openalex.org/W2045058338","https://openalex.org/W2046193077","https://openalex.org/W2054323958","https://openalex.org/W2055068580","https://openalex.org/W2056184913","https://openalex.org/W2061871664","https://openalex.org/W2062106705","https://openalex.org/W2070663758","https://openalex.org/W2070771447","https://openalex.org/W2071504629","https://openalex.org/W2072467180","https://openalex.org/W2073213000","https://openalex.org/W2076336531","https://openalex.org/W2080228333","https://openalex.org/W2083650072","https://openalex.org/W2098738258","https://openalex.org/W2106859330","https://openalex.org/W2107353400","https://openalex.org/W2108167035","https://openalex.org/W2111420487","https://openalex.org/W2126772533","https://openalex.org/W2127736404","https://openalex.org/W2127752492","https://openalex.org/W2129088448","https://openalex.org/W2132649715","https://openalex.org/W2133152330","https://openalex.org/W2148012276","https://openalex.org/W2150274550","https://openalex.org/W2152290963","https://openalex.org/W2155268095","https://openalex.org/W2159061031","https://openalex.org/W2166615754","https://openalex.org/W2169193886","https://openalex.org/W2169314170","https://openalex.org/W2259938310","https://openalex.org/W2292125616","https://openalex.org/W2401979083","https://openalex.org/W2415695405","https://openalex.org/W2419037582","https://openalex.org/W4229645144","https://openalex.org/W4244900749","https://openalex.org/W6640960890"],"related_works":["https://openalex.org/W1954706707","https://openalex.org/W2908205139","https://openalex.org/W1876387579","https://openalex.org/W2936887275","https://openalex.org/W2073419931","https://openalex.org/W1964142218","https://openalex.org/W2068415373","https://openalex.org/W2011503104","https://openalex.org/W2739088795","https://openalex.org/W4402201797"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Cytochrome":[1],"P450":[2],"3A4":[3],"(CYP3A4)":[4],"is":[5],"involved":[6],"in":[7,44,95,158,193,229],"the":[8,15,19,66,82,116,163,180,227],"metabolism":[9],"of":[10,14,73,84,98,115,162,179,226,241,248],"greater":[11],"than":[12],"50%":[13],"prescribed":[16],"drugs.":[17],"Recently,":[18],"CYP3A4*22":[20,45,67,136,166,242],"allele":[21],"was":[22,146],"reported":[23],"to":[24,63,224,263],"be":[25,233],"associated":[26],"with":[27,81,148],"lower":[28],"CYP3A4":[29,58,253],"expression":[30],"and":[31,50,59,78,109,168,190,209,254],"activity.":[32],"Quetiapine,":[33],"an":[34],"antipsychotic":[35],"metabolized":[36,56,250],"by":[37,57,235,251],"only":[38,222],"CYP3A4,":[39],"displayed":[40],"higher":[41,192],"serum":[42,71,159,246,261],"levels":[43,114,247,262],"carriers.":[46],"Aripiprazole,":[47],"haloperidol,":[48,105],"pimozide,":[49,108],"risperidone":[51,210],"are":[52,55],"antipsychotics":[53,164,249],"that":[54,221],"CYP2D6.":[60],"We":[61],"investigated":[62],"which":[64],"degree":[65],"single-nucleotide":[68],"polymorphism":[69,141],"affects":[70],"concentrations":[72,161,178,186,231],"patients":[74,92],"receiving":[75],"these":[76,230],"drugs":[77],"compared":[79],"this":[80,96],"influence":[83],"CYP2D6":[85,145,173,236,257],"polymorphisms.":[86],"METHODS:":[87],"Eight":[88],"hundred":[89],"thirty-four":[90],"adult":[91],"were":[93,124,133,156,187],"included":[94],"study,":[97],"whom":[99],"130":[100],"used":[101,104,107,111],"aripiprazole,":[102],"312":[103],"86":[106],"396":[110],"risperidone.":[112],"Serum":[113],"drug":[117],"and,":[118],"if":[119],"available,":[120],"their":[121],"active":[122],"metabolites":[123],"collected":[125],"as":[126,128],"well":[127],"information":[129],"on":[130],"dose.":[131],"Patients":[132],"genotyped":[134],"for":[135,144,182,200],"using":[137],"restriction":[138],"fragment":[139],"length":[140],"analysis.":[142],"Genotyping":[143],"done":[147],"allele-specific":[149],"polymerase":[150],"chain":[151],"reaction.":[152],"RESULTS:":[153],"No":[154],"differences":[155],"found":[157],"(dose-corrected)":[160],"between":[165],"wild-type":[167],"carrier":[169],"groups.":[170],"In":[171],"contrast,":[172],"genotype":[174],"did":[175],"affect":[176,260],"dose-corrected":[177,185],"antipsychotics:":[181],"example,":[183],"median":[184],"56%,":[188],"86%,":[189],"400%":[191],"predicted":[194],"poor":[195],"metabolizers":[196,199],"versus":[197],"extensive":[198],"aripiprazole":[201],"(P":[202,206,211],"=":[203],"0.004),":[204],"haloperidol":[205],">":[207],"0.001),":[208,213],"<":[212],"respectively,":[214],"although":[215],"a":[216,264],"multiple":[217],"regression":[218],"analysis":[219],"showed":[220],"4%":[223],"17%":[225],"variation":[228],"could":[232],"explained":[234],"status.":[237],"CONCLUSIONS:":[238],"Heterozygous":[239],"presence":[240],"does":[243],"not":[244],"increase":[245],"both":[252],"CYP2D6,":[255],"whereas":[256],"polymorphisms":[258],"do":[259],"limited":[265],"extent.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
