{"id":"https://openalex.org/W2403236372","doi":null,"title":"Consequences of not treating children with laron syndrome (primary growth hormone insensitivity).","display_name":"Consequences of not treating children with laron syndrome (primary growth hormone insensitivity).","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2403236372","mag":"2403236372","pmid":"https://pubmed.ncbi.nlm.nih.gov/11964019"},"language":"en","primary_location":{"id":"pmid:11964019","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11964019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric endocrinology & metabolism : JPEM","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090768607","display_name":"Zvi Laron","orcid":"https://orcid.org/0000-0002-4058-5758","observed_orcids":["https://orcid.org/0000-0002-4058-5758"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I4210109312","display_name":"Schneider Children's Medical Center","ror":"https://ror.org/01z3j3n30","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210109312"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Z Laron","raw_affiliation_strings":["Endocrinology and Diabetes Research Unit, Schneider Children's Medical Center, Tel Aviv University, Israel. laronz@clalit.org.il"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology and Diabetes Research Unit, Schneider Children's Medical Center, Tel Aviv University, Israel. laronz@clalit.org.il","institution_ids":["https://openalex.org/I16391192","https://openalex.org/I4210109312"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090768607"],"corresponding_institution_ids":["https://openalex.org/I16391192","https://openalex.org/I4210109312"],"apc_list":null,"apc_paid":null,"fwci":0.9292,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.77234908,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"14 Suppl 5","issue":null,"first_page":"1243","last_page":"8; discussion 1261"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laron-syndrome","display_name":"Laron syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/growth-hormone-therapy","display_name":"growth hormone therapy","score":0.4519999921321869},{"id":"https://openalex.org/keywords/short-stature","display_name":"short stature","score":0.7689999938011169},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7369999885559082},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9950000047683716},{"id":"https://openalex.org/keywords/skeletal-maturation","display_name":"skeletal maturation","score":0.781000018119812},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9620000123977661},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8539999723434448},{"id":"https://openalex.org/keywords/long-term-follow-up","display_name":"long-term follow-up","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9264836311340332},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6784967184066772},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6288471221923828},{"id":"https://openalex.org/C2778111144","wikidata":"https://www.wikidata.org/wiki/Q194101","display_name":"Dwarfism","level":3,"score":0.5929460525512695},{"id":"https://openalex.org/C1008401","wikidata":"https://www.wikidata.org/wiki/Q184681","display_name":"Anabolism","level":2,"score":0.5742702484130859},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006130","descriptor_name":"Growth Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006130","descriptor_name":"Growth Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006130","descriptor_name":"Growth Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006130","descriptor_name":"Growth Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D006130","descriptor_name":"Growth Disorders","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:11964019","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11964019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric endocrinology & metabolism : JPEM","raw_type":"Journal Article"},{"id":"mag:2403236372","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11964019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2082691596","https://openalex.org/W156210519","https://openalex.org/W4414393085","https://openalex.org/W2412722659","https://openalex.org/W3186146116","https://openalex.org/W2123793880","https://openalex.org/W2066936742","https://openalex.org/W2336816988","https://openalex.org/W1968124424","https://openalex.org/W127292142"],"abstract_inverted_index":{"The":[0],"follow-up":[1],"of":[2,6,24,49,61,78,89,91],"a":[3,76],"large":[4],"cohort":[5],"patients":[7,98],"with":[8,99],"Laron":[9],"syndrome":[10],"(LS)":[11],"from":[12],"infancy":[13],"to":[14,20],"adult":[15],"age":[16],"has":[17],"enabled":[18],"us":[19],"determine":[21],"the":[22,87],"effects":[23],"long-term":[25],"insulin-like":[26],"growth":[27,50],"factor-I":[28],"(IGF-I)":[29],"deficiency":[30,45],"on":[31],"auxological,":[32],"biochemical,":[33],"physiological":[34],"and":[35,42,64,70,75],"psychological":[36],"parameters.":[37],"We":[38],"found":[39],"that":[40,97],"early":[41],"continuous":[43],"IGF-I":[44,102],"(the":[46],"anabolic":[47],"effector":[48],"hormone)":[51],"causes":[52],"dwarfism,":[53],"acromicria,":[54],"organomicria,":[55],"marked":[56],"obesity,":[57],"insulin":[58],"resistance,":[59],"retardation":[60],"skeletal":[62],"maturation":[63],"osteoporosis,":[65],"as":[66,68],"well":[67],"muscular":[69],"central":[71],"nervous":[72],"tissue":[73],"underdevelopment,":[74],"series":[77],"biochemical":[79],"changes":[80],"including":[81],"hypercholesterolemia.":[82],"These":[83],"multiple":[84],"pathologies":[85],"impair":[86],"quality":[88],"life":[90],"these":[92],"patients.":[93],"It":[94],"is":[95],"concluded":[96],"LS":[100],"need":[101],"replacement":[103],"treatment":[104],"throughout":[105],"life.":[106]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
