{"id":"https://openalex.org/W2403188976","doi":"https://doi.org/10.18632/oncotarget.9617","title":"Integrin alphavbeta3 enhances \u03b2-catenin signaling in acute myeloid leukemia harboring Fms-like tyrosine kinase-3 internal tandem duplication mutations: implications for microenvironment influence on sorafenib sensitivity","display_name":"Integrin alphavbeta3 enhances \u03b2-catenin signaling in acute myeloid leukemia harboring Fms-like tyrosine kinase-3 internal tandem duplication mutations: implications for microenvironment influence on sorafenib sensitivity","publication_year":2016,"publication_date":"2016-05-26","ids":{"openalex":"https://openalex.org/W2403188976","doi":"https://doi.org/10.18632/oncotarget.9617","mag":"2403188976","pmid":"https://pubmed.ncbi.nlm.nih.gov/27248172","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5130015"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.9617","doi":"https://doi.org/10.18632/oncotarget.9617","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.9617","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=9617&path%5B%5D=31244","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=9617&path%5B%5D=31244","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008439423","display_name":"Hai Yi","orcid":"https://orcid.org/0000-0003-3794-266X","observed_orcids":["https://orcid.org/0000-0003-3794-266X"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210104667","display_name":"Chengdu Military General Hospital","ror":"https://ror.org/01bk73674","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104667"]},{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai Yi","raw_affiliation_strings":["Department of Hematology, General Hospital of Chengdu Military Region, Chengdu, 610083, People's Republic of China","Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, General Hospital of Chengdu Military Region, Chengdu, 610083, People's Republic of China","institution_ids":["https://openalex.org/I4210104667"]},{"raw_affiliation_string":"Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People's Republic of China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020588158","display_name":"Dongfeng Zeng","orcid":"https://orcid.org/0000-0002-0460-7593","observed_orcids":["https://orcid.org/0000-0002-0460-7593"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongfeng Zeng","raw_affiliation_strings":["Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People's Republic of China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103008047","display_name":"Zhaohua Shen","orcid":"https://orcid.org/0000-0003-3518-8202","observed_orcids":["https://orcid.org/0000-0003-3518-8202"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaohua Shen","raw_affiliation_strings":["Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People's Republic of China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101113276","display_name":"Jun Liao","orcid":"https://orcid.org/0009-0003-3555-5962","observed_orcids":["https://orcid.org/0009-0003-3555-5962","https://orcid.org/0000-0003-0617-5840"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Liao","raw_affiliation_strings":["Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People's Republic of China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaoguo Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoguo Wang","raw_affiliation_strings":["Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People's Republic of China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100463094","display_name":"Yao Z. Liu","orcid":"https://orcid.org/0000-0003-1782-7322","observed_orcids":["https://orcid.org/0000-0003-1782-7322"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Liu","raw_affiliation_strings":["Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People's Republic of China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100430853","display_name":"Xi Zhang","orcid":"https://orcid.org/0000-0002-8548-2832","observed_orcids":["https://orcid.org/0000-0002-8548-2832"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Zhang","raw_affiliation_strings":["Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People's Republic of China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086896775","display_name":"Peiyan Kong","orcid":"https://orcid.org/0000-0003-3662-3990","observed_orcids":["https://orcid.org/0000-0003-3662-3990"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Peiyan Kong","raw_affiliation_strings":["Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People's Republic of China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5086896775"],"corresponding_institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"],"apc_list":null,"apc_paid":null,"fwci":4.6055,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.94981928,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"26","first_page":"40387","last_page":"40397"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrin-alphavbeta3","display_name":"integrin \u03b1v\u03b23","score":0.9100000262260437},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9089999794960022},{"id":"https://openalex.org/keywords/flt3-itd-mutation","display_name":"FLT3-ITD","score":0.9409999847412109},{"id":"https://openalex.org/keywords/beta-catenin-signaling","display_name":"\u03b2-catenin signaling","score":0.9129999876022339},{"id":"https://openalex.org/keywords/sorafenib-sensitivity","display_name":"sorafenib sensitivity","score":0.9229999780654907},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.8600000143051147},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8270000219345093},{"id":"https://openalex.org/keywords/pi3k-akt-gsk3beta-pathway","display_name":"PI3K/AKT/GSK3\u03b2 pathway","score":0.8820000290870667},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6050000190734863},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7549999952316284},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6629999876022339},{"id":"https://openalex.org/keywords/mv4-11-cells","display_name":"MV4-11 cells","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.7987171411514282},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7131130695343018},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.6790587902069092},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5424003005027771},{"id":"https://openalex.org/C2910954276","wikidata":"https://www.wikidata.org/wiki/Q14912399","display_name":"Fms-Like Tyrosine Kinase 3","level":4,"score":0.5375912189483643},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.48468998074531555},{"id":"https://openalex.org/C2780804394","wikidata":"https://www.wikidata.org/wiki/Q411994","display_name":"Osteopontin","level":2,"score":0.44186514616012573},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.419050008058548},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.41342025995254517},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37205660343170166},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2832823395729065},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2648070454597473},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19564583897590637},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.15126186609268188},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11422339081764221},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07841810584068298},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077157","descriptor_name":"Sorafenib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015973","descriptor_name":"Gene Expression Regulation, Leukemic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039302","descriptor_name":"Integrin alphaVbeta3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051941","descriptor_name":"fms-Like Tyrosine Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053495","descriptor_name":"Osteopontin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.18632/oncotarget.9617","doi":"https://doi.org/10.18632/oncotarget.9617","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.9617","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=9617&path%5B%5D=31244","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4088091","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5130015","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27248172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27248172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5130015","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5130015/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.9617","doi":"https://doi.org/10.18632/oncotarget.9617","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.9617","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=9617&path%5B%5D=31244","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1034265866","display_name":"\u963b\u65adTHPO/MPL\u4fe1\u53f7\u901a\u8def\u8c03\u63a7\"\u6210\u9aa8\u7ec6\u80de\u9f9b\"\u5c4f\u853d\u9f9b\u5185\u767d\u8840\u75c5\u7ec6\u80de\u529f\u80fd\u7684\u7814\u7a76","funder_award_id":"81000195","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2403188976.pdf","grobid_xml":"https://content.openalex.org/works/W2403188976.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1255676896","https://openalex.org/W1557808229","https://openalex.org/W1970267589","https://openalex.org/W1975054670","https://openalex.org/W1980952112","https://openalex.org/W1984619334","https://openalex.org/W1991979883","https://openalex.org/W1998973639","https://openalex.org/W2014623749","https://openalex.org/W2017107901","https://openalex.org/W2027364921","https://openalex.org/W2028243804","https://openalex.org/W2029572050","https://openalex.org/W2030350068","https://openalex.org/W2031321792","https://openalex.org/W2034269170","https://openalex.org/W2034876218","https://openalex.org/W2050108686","https://openalex.org/W2056465113","https://openalex.org/W2060300682","https://openalex.org/W2069561533","https://openalex.org/W2087963453","https://openalex.org/W2094377883","https://openalex.org/W2100703148","https://openalex.org/W2115536079","https://openalex.org/W2121235111","https://openalex.org/W2147000598","https://openalex.org/W2152711979","https://openalex.org/W2153641896","https://openalex.org/W2164765170","https://openalex.org/W4250877149"],"related_works":["https://openalex.org/W2783233297","https://openalex.org/W2152214606","https://openalex.org/W2580538314","https://openalex.org/W1777820531","https://openalex.org/W2017107901","https://openalex.org/W2233133745","https://openalex.org/W2910412094","https://openalex.org/W2609090402","https://openalex.org/W4310106378","https://openalex.org/W4362543803"],"abstract_inverted_index":{"//":[0],"Hai":[1],"Yi":[2],"1,":[3],"2":[4,49],",":[5,9,13,17,21,25,29],"Dongfeng":[6],"Zeng":[7],"1":[8,12,16,20,24,28,32,33],"Zhaohua":[10],"Shen":[11],"Jun":[14],"Liao":[15],"Xiaoguo":[18],"Wang":[19],"Yao":[22],"Liu":[23],"Xi":[26],"Zhang":[27],"Peiyan":[30,67],"Kong":[31],"Department":[34,50],"of":[35,47,51,55,63,99,118,126,165,176,187,212,253],"Hematology,":[36,52],"Xinqiao":[37],"Hospital,":[38],"Third":[39],"Military":[40,57],"Medical":[41],"University,":[42],"Chongqing,":[43],"400037,":[44],"People's":[45,61],"Republic":[46,62],"China":[48,64],"General":[53],"Hospital":[54],"Chengdu":[56],"Region,":[58],"Chengdu,":[59],"610083,":[60],"Correspondence":[65],"to:":[66],"Kong,":[68],"email:":[69],"peiyankong@aliyun.com":[70],"Keywords:":[71],"integrin,":[72],"acute":[73,119],"myeloid":[74,120],"leukemia,":[75],"Fms-like":[76,195],"tyrosine":[77,196],"kinase-3":[78,197,246],"internal":[79,198],"tandem":[80,199],"duplication,":[81],"\u03b2-catenin,":[82],"drug":[83,113],"sensitivity":[84,161,209,260,277],"Received:":[85],"October":[86],"29,":[87],"2015":[88],"Accepted:":[89],"May":[90,94],"06,":[91],"2016":[92,96],"Published:":[93],"26,":[95],"ABSTRACT":[97],"Binding":[98],"leukemia":[100,121],"cells":[101,168,214,219],"to":[102,132],"the":[103,116,124],"bone":[104,216],"marrow":[105,217],"extracellular":[106],"matrix":[107],"(ECM)":[108],"through":[109,241],"integrins":[110],"might":[111],"influence":[112,274],"response":[114],"and":[115,144,149,162,185,215,221],"survival":[117],"(AML).":[122],"However,":[123],"functions":[125],"integrin":[127,145,288],"in":[128,159,171,191,231,261,272,278],"AML":[129,153,167,188,234,279,302],"are":[130],"needed":[131],"be":[133,294],"clarified.":[134],"Data":[135],"from":[136],"The":[137,174],"Cancer":[138],"Genome":[139],"Atlas":[140],"(TCGA)":[141],"were":[142,154],"retrieved":[143],"\u03b23":[146],"(ITGB3)":[147],"expression":[148,178],"prognostic":[150],"significance":[151],"for":[152,225,301,304],"analyzed.":[155],"Integrin":[156,205,291],"alphavbeta3":[157],"(\u03b1v\u03b23)":[158],"sorafenib":[160,208,229,259,276],"signaling":[163],"pathway":[164],"FLT3-ITD":[166,202,232,281,305],"was":[169,179,284],"evaluated":[170],"vitro":[172],".":[173],"level":[175],"ITGB3":[177],"positively":[180],"correlated":[181],"with":[182,194,280],"risk":[183],"stratification":[184],"prognosis":[186],"patients,":[189],"especially":[190,303],"cytogenetic-normal":[192],"patients":[193],"duplication":[200],"(":[201],")":[203],"mutation.":[204],"\u03b1v\u03b23":[206,237],"decreased":[207],"when":[210],"co-culture":[211],"MV4-11":[213,262],"stromal":[218],"(BMSCs),":[220],"it":[222],"is":[223],"crucial":[224],"osteopontin":[226],"(OPN)":[227],"induced":[228],"insensitivity":[230],"mutated":[233,306],"cells.":[235,263],"Mechanically,":[236],"enhance":[238],"\u03b2-catenin":[239,254],"activation":[240],"phosphatidylinositol":[242],"3-kinase":[243],"(PI3K)/Akt/Glycogen":[244],"synthase":[245],"beta":[247],"(GSK3\u03b2)":[248],"pathway.":[249,290],"Moreover,":[250],"genetic":[251],"inhibition":[252],"by":[255,286],"shRNA":[256],"could":[257,293],"increase":[258],"Taken":[264],"together,":[265],"our":[266],"study":[267],"revealed":[268],"a":[269,297],"novel":[270],"mechanism":[271],"microenvironment":[273],"on":[275],"mutation":[282],"that":[283],"caused":[285],"activating":[287],"\u03b1v\u03b23/PI3K/Akt/GSK3\u03b2/\u03b2-catenin":[289],"\u03b1v\u03b23/\u03b2-catenin":[292],"considered":[295],"as":[296],"new":[298],"therapeutic":[299],"target":[300],"AML.":[307]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
