{"id":"https://openalex.org/W2403178461","doi":null,"title":"Renal safety pharmacology: value of sensitized experimental models.","display_name":"Renal safety pharmacology: value of sensitized experimental models.","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2403178461","mag":"2403178461","pmid":"https://pubmed.ncbi.nlm.nih.gov/10860006"},"language":"en","primary_location":{"id":"pmid:10860006","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10860006","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapie","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111572470","display_name":"JM Id\u00e9e","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I120615911","display_name":"Guerbet (France)","ror":"https://ror.org/0504sxa76","country_code":"FR","type":"company","lineage":["https://openalex.org/I120615911"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"J M Id\u00e9e","raw_affiliation_strings":["Laboratoires Guerbet, Research Division, Roissy-Charles de Gaulle, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires Guerbet, Research Division, Roissy-Charles de Gaulle, France","institution_ids":["https://openalex.org/I120615911"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111572470"],"corresponding_institution_ids":["https://openalex.org/I120615911"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"55","issue":"1","first_page":"91","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9369999766349792},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.8040000200271606},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.9670000076293945},{"id":"https://openalex.org/keywords/renal-blood-flow","display_name":"renal blood flow","score":0.9100000262260437},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.9950000047683716},{"id":"https://openalex.org/keywords/enzymuria","display_name":"enzymuria","score":0.8220000267028809},{"id":"https://openalex.org/keywords/fractional-excretion-of-sodium","display_name":"fractional excretion of sodium","score":0.953000009059906},{"id":"https://openalex.org/keywords/salt-depletion","display_name":"salt depletion","score":0.6579999923706055},{"id":"https://openalex.org/keywords/dehydration","display_name":"dehydration","score":0.9340000152587891},{"id":"https://openalex.org/keywords/drug-candidates","display_name":"drug candidates","score":0.41499999165534973},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.7035307884216309},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6647335290908813},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.6535634398460388},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.5622574687004089},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5475162863731384},{"id":"https://openalex.org/C142225936","wikidata":"https://www.wikidata.org/wiki/Q1129139","display_name":"Renal blood flow","level":3,"score":0.5278998017311096},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.47146445512771606},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.4439217448234558},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.42454618215560913},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.38475796580314636},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28735965490341187}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010601","descriptor_name":"Pharmacology, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:10860006","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10860006","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapie","raw_type":"Journal Article"},{"id":"mag:2403178461","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10860006","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7217690824","https://openalex.org/W2142070789","https://openalex.org/W4319780721","https://openalex.org/W2042476337","https://openalex.org/W1929675471","https://openalex.org/W2334676776","https://openalex.org/W2919629571","https://openalex.org/W3022537792","https://openalex.org/W4255155671","https://openalex.org/W1986018570"],"abstract_inverted_index":{"The":[0,38],"kidneys":[1],"are":[2,72,99],"an":[3],"important":[4],"target":[5],"for":[6],"toxic":[7],"effects":[8,32],"of":[9,45,55,60,69,82,130,153],"drug":[10],"candidates.":[11],"It":[12],"is":[13,50,139],"mandatory":[14],"to":[15,23,28,43,76,105,113],"select":[16],"accurate,":[17],"clinically":[18],"relevant":[19],"parameters":[20,109],"in":[21,25,121,132],"order":[22],"be":[24,44,145],"a":[26,83],"position":[27],"detect":[29,77],"putative":[30],"nephrotoxic":[31],"during":[33],"the":[34,53,61,87,92,114],"safety":[35],"pharmacology":[36],"programme.":[37],"glomerular":[39],"filtration":[40],"rate":[41],"appears":[42],"major":[46],"interest":[47],"since":[48],"it":[49,138],"associated":[51],"with":[52,134],"definition":[54],"acute":[56,124],"renal":[57,62,80,125],"failure.":[58],"Measurement":[59],"blood":[63],"flow,":[64],"proteinuria,":[65],"enzymuria,":[66],"fractional":[67],"excretion":[68],"sodium,":[70],"etc.":[71,119],"also":[73],"highly":[74],"useful":[75],"any":[78],"possible":[79],"impact":[81],"new":[84],"compound.":[85],"Although":[86],"rat":[88],"is,":[89],"by":[90],"far,":[91],"most":[93,122],"widely":[94],"used":[95,148],"animal":[96,143],"species,":[97,115],"there":[98],"no":[100],"specific":[101],"(clinically":[102],"relevant)":[103],"reasons":[104],"choose":[106],"it.":[107],"Various":[108],"may":[110],"vary":[111],"according":[112],"sex,":[116],"strain,":[117],"age,":[118],"Since":[120],"cases":[123],"failure":[126],"occurs":[127],"following":[128],"administration":[129],"drugs":[131],"patients":[133],"pre-existing":[135],"risk":[136],"factors,":[137],"suggested":[140],"that":[141],"sensitized":[142],"models":[144],"validated":[146],"and":[147],"(salt":[149],"depletion,":[150],"dehydration,":[151],"co-administration":[152],"pharmacologic":[154],"agents,":[155],"etc.).":[156]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
