{"id":"https://openalex.org/W2403021533","doi":"https://doi.org/10.25560/30778","title":"The impact of inflammation on pregnancy outcomes","display_name":"The impact of inflammation on pregnancy outcomes","publication_year":2015,"publication_date":"2015-09-01","ids":{"openalex":"https://openalex.org/W2403021533","doi":"https://doi.org/10.25560/30778","mag":"2403021533"},"language":"en","primary_location":{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/30778","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/30778","pdf_url":"http://hdl.handle.net/10044/1/30778","source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or dissertation"},"volume":null,"type":"dissertation","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10044/1/30778","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Howe, Laura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Howe, Laura","raw_affiliation_strings":["Imperial College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12715","display_name":"Pregnancy-related medical research","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inflammation-in-pregnancy","display_name":"inflammation in pregnancy","score":0.7440000176429749},{"id":"https://openalex.org/keywords/maternal-sepsis","display_name":"maternal sepsis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/gestational-hypertension","display_name":"gestational hypertension","score":0.5099999904632568},{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.8640000224113464},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.8040000200271606},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.8579999804496765},{"id":"https://openalex.org/keywords/ddah1","display_name":"DDAH1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nitric-oxide-signaling","display_name":"nitric oxide signaling","score":0.9919999837875366},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/maternal-mortality","display_name":"maternal mortality","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.627498984336853},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5012497901916504},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4841226041316986},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26597321033477783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19671449065208435},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/30778","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/30778","pdf_url":"http://hdl.handle.net/10044/1/30778","source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or dissertation"},{"id":"pmh:doi:10.25560/30778","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10044/1/30778","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"doi:10.25560/30778","doi":"https://doi.org/10.25560/30778","is_oa":true,"landing_page_url":"https://doi.org/10.25560/30778","pdf_url":null,"source":{"id":"https://openalex.org/S7407050757","display_name":"Imperial College Research Computing Service Data Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"mag:2403021533","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.682097","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/30778","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10044/1/30778","pdf_url":"http://hdl.handle.net/10044/1/30778","source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or dissertation"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2403021533.pdf","grobid_xml":"https://content.openalex.org/works/W2403021533.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2735237449","https://openalex.org/W2973576916","https://openalex.org/W2897212011","https://openalex.org/W2105378955","https://openalex.org/W2941436610","https://openalex.org/W2044508115","https://openalex.org/W1899873857","https://openalex.org/W2152246270","https://openalex.org/W1983655334","https://openalex.org/W2139305080"],"abstract_inverted_index":{"Sepsis":[0],"is":[1,65,99],"the":[2,10,19,26,34,52,55,77,85,116,143,201,229,243,261,276],"leading":[3,15],"cause":[4],"of":[5,28,135,145,191,200,224,228,264],"direct":[6],"maternal":[7,22,121,148],"mortality":[8,59],"in":[9,33,71,75,167,181,211,250,253],"UK,":[11],"but":[12],"also":[13],"a":[14,132,151,188,226],"concern":[16],"worldwide.":[17],"In":[18,82,126],"USA,":[20],"severe":[21],"sepsis":[23],"rates":[24],"and":[25,45,58,79,90,110,118,174,217],"risk":[27],"sepsis-related":[29],"death":[30],"have":[31],"doubled":[32],"last":[35],"decade.":[36],"There":[37],"appears":[38],"to":[39,88,104,128,130,141,154,163,171,207,255,259,267],"be":[40,124,272],"an":[41,100,236],"increased":[42,56],"susceptibility":[43,263],"to,":[44],"severity":[46],"of,":[47],"infections":[48],"during":[49,137],"pregnancy.":[50],"However,":[51],"mechanisms":[53],"behind":[54],"morbidity":[57],"are":[60],"not":[61,179,194,240],"fully":[62],"understood.":[63],"Pregnancy":[64],"associated":[66],"with":[67,185],"acute":[68],"physiological":[69],"changes":[70],"most":[72],"organ":[73],"systems,":[74],"particular":[76],"cardiovascular":[78,119],"immune":[80,117,277],"systems.":[81],"this":[83,159,196],"thesis":[84],"haemodynamic":[86,102,175,245],"response":[87,103,254],"infection":[89,105],"inflammation":[91,146,166],"was":[92,95,139,161,205],"investigated.":[93],"It":[94],"hypothesised":[96],"that":[97,165,177],"there":[98],"altered":[101],"mediated":[106],"by":[107,111,214,274],"inflammatory":[108],"pathways,":[109],"targeting":[112],"signalling":[113,232],"pathways":[114],"within":[115],"systems":[120],"outcomes":[122,270],"could":[123],"improved.":[125],"order":[127],"achieve":[129],"this,":[131],"murine":[133],"model":[134,160],"endotoxaemia":[136],"pregnancy":[138,168],"employed":[140],"study":[142],"effects":[144],"on":[147],"haemodynamics,":[149],"utilising":[150],"telemetric":[152],"technique":[153],"monitor":[155],"physiologic":[156],"changes.":[157],"Firstly,":[158],"used":[162],"demonstrate":[164],"can":[169],"lead":[170],"marked":[172,248],"hypotension":[173,210],"dysfunction":[176],"does":[178],"occur":[180],"non-pregnant":[182],"controls.":[183],"Supplementation":[184],"additional":[186],"progesterone,":[187],"key":[189],"hormone":[190],"pregnancy,":[192,212],"did":[193,239],"exacerbate":[195],"hypotensive":[197],"effect.":[198],"Manipulation":[199,220],"chemokine":[202],"receptor":[203],"CCR2":[204],"able":[206],"reverse":[208],"inflammation-induced":[209],"both":[213],"genetic":[215,222],"knockout":[216,223],"pharmacological":[218],"inhibition.":[219],"via":[221],"DDAH1,":[225],"component":[227],"nitric":[230],"oxide":[231],"pathway,":[233],"whilst":[234],"conferring":[235],"initial":[237],"hypertension":[238],"significantly":[241],"impact":[242],"gestational":[244],"profile.":[246],"The":[247],"fall":[249],"blood":[251],"pressure":[252],"endotoxin":[256],"may":[257,271],"help":[258],"explain":[260],"greater":[262],"pregnant":[265],"women":[266],"sepsis.":[268],"Maternal":[269],"improved":[273],"modulating":[275],"response.":[278]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
