{"id":"https://openalex.org/W2403006992","doi":null,"title":"[Successful treatment by 4--aminopyridine of three cases of severe verapamil poisoning].","display_name":"[Successful treatment by 4--aminopyridine of three cases of severe verapamil poisoning].","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2403006992","mag":"2403006992","pmid":"https://pubmed.ncbi.nlm.nih.gov/14569901"},"language":"pl","primary_location":{"id":"pmid:14569901","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14569901","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Przeglad lekarski","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022106917","display_name":"Jan Magdalan","orcid":"https://orcid.org/0000-0002-2324-9250","observed_orcids":["https://orcid.org/0000-0002-2324-9250"]},"institutions":[{"id":"https://openalex.org/I385303915","display_name":"Wroclaw Medical University","ror":"https://ror.org/01qpw1b93","country_code":"PL","type":"education","lineage":["https://openalex.org/I385303915"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jan Magdalan","raw_affiliation_strings":["Katedra i Zak\u0142ad Farmakologii Akademii Medycznej we Wroc\u0142awiu, 50-345 Wroc\u0142aw, ul. Mikulicza-Radeckiego 2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Katedra i Zak\u0142ad Farmakologii Akademii Medycznej we Wroc\u0142awiu, 50-345 Wroc\u0142aw, ul. Mikulicza-Radeckiego 2","institution_ids":["https://openalex.org/I385303915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089108920","display_name":"Krystyna Kochman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krystyna Kochman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103695542","display_name":"Andrzej Anto\u0144czyk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrzej Anto\u0144czyk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079064726","display_name":"Micha\u0142 Przew\u0142ocki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michal Przew\u0142ocki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Ma\u0142gorzata Smolarek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ma\u0142gorzata Smolarek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.3531535,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"60","issue":"4","first_page":"271","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13095","display_name":"Plant-based Medicinal Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/verapamil-poisoning","display_name":"verapamil poisoning","score":0.9950000047683716},{"id":"https://openalex.org/keywords/4-aminopyridine","display_name":"4-aminopyridine","score":0.9539999961853027},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.7360000014305115},{"id":"https://openalex.org/keywords/cardiogenic-shock","display_name":"cardiogenic shock","score":0.7760000228881836},{"id":"https://openalex.org/keywords/circulatory-insufficiency","display_name":"circulatory insufficiency","score":0.9679999947547913},{"id":"https://openalex.org/keywords/atrioventricular-block","display_name":"atrioventricular block","score":0.9150000214576721},{"id":"https://openalex.org/keywords/respiratory-failure","display_name":"respiratory failure","score":0.8539999723434448},{"id":"https://openalex.org/keywords/potassium-channel-blockade","display_name":"potassium channel blockade","score":0.7329999804496765},{"id":"https://openalex.org/keywords/overdose-treatment","display_name":"drug overdose treatment","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C2777022698","wikidata":"https://www.wikidata.org/wiki/Q410291","display_name":"Verapamil","level":3,"score":0.8755029439926147},{"id":"https://openalex.org/C2776850375","wikidata":"https://www.wikidata.org/wiki/Q2477062","display_name":"Cardiogenic shock","level":3,"score":0.6779337525367737},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.6652863025665283},{"id":"https://openalex.org/C72859922","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Circulatory system","level":2,"score":0.655206561088562},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6530700922012329},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.596910297870636},{"id":"https://openalex.org/C2778557577","wikidata":"https://www.wikidata.org/wiki/Q300121","display_name":"Atrioventricular block","level":2,"score":0.5523784160614014},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.535697877407074},{"id":"https://openalex.org/C2776371345","wikidata":"https://www.wikidata.org/wiki/Q5121708","display_name":"Circulatory collapse","level":2,"score":0.47639885544776917},{"id":"https://openalex.org/C2775859210","wikidata":"https://www.wikidata.org/wiki/Q26272","display_name":"Atropine","level":2,"score":0.43076133728027344},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4066951274871826},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39671051502227783},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.08653756976127625}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006327","descriptor_name":"Heart Block","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006327","descriptor_name":"Heart Block","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013406","descriptor_name":"Suicide, Attempted","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":true},{"descriptor_ui":"D014700","descriptor_name":"Verapamil","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":true},{"descriptor_ui":"D015761","descriptor_name":"4-Aminopyridine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D026902","descriptor_name":"Potassium Channel Blockers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:14569901","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14569901","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Przeglad lekarski","raw_type":"Case Reports"},{"id":"mag:2403006992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14569901","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W45393500","https://openalex.org/W1978744911","https://openalex.org/W45619562","https://openalex.org/W2036145441","https://openalex.org/W2328372095","https://openalex.org/W2104915325","https://openalex.org/W2415424212","https://openalex.org/W1542464665","https://openalex.org/W2062548221","https://openalex.org/W2526108573"],"abstract_inverted_index":{"Three":[0],"cases":[1,9,80],"of":[2,52,59,67,71,84,89,94,97,102,112,140],"verapamil":[3,90],"intoxication":[4],"were":[5,14,24],"presented.":[6],"In":[7,16],"all":[8],"shock":[10,75],"and":[11,22,41,55,76,138],"circulatory":[12,39,77],"insufficiency":[13,21,40],"observed.":[15],"case":[17,27],"no.":[18,28],"1":[19],"respiratory":[20],"confusion":[23],"observed,":[25],"in":[26,64,86,124],"3":[29],"second-degree":[30],"atrioventricular":[31,42,72],"block":[32,43],"was":[33],"noted.":[34],"The":[35,57,110],"protracted":[36],"hypotension":[37],"(shock),":[38],"did":[44],"not":[45],"respond":[46],"to":[47,130,136],"calcium":[48,103,115,142],"therapy,":[49],"high":[50],"dose":[51],"vasopressor":[53],"amines":[54],"atropine.":[56],"addition":[58],"4-aminopyridine":[60],"(4-AP)":[61],"infusion":[62],"resulted":[63],"fast":[65],"receding":[66,70],"poisoning":[68,105],"symptoms;":[69],"block,":[73],"cardiogenic":[74],"insufficiency.":[78],"These":[79],"suggest":[81],"the":[82,87,95,133],"usefulness":[83],"4-AP":[85,113],"treatment":[88],"poisoning.":[91],"However,":[92],"confirmation":[93],"effectiveness":[96],"this":[98],"substance":[99],"for":[100],"pharmacotherapy":[101],"antagonists":[104],"requires":[106],"further":[107],"clinical":[108],"research.":[109],"influence":[111],"on":[114],"channels":[116,122],"is":[117],"indirect.":[118],"It":[119],"blocks":[120],"potassium":[121,129],"K1":[123],"cytoplasm":[125],"side":[126],"which":[127],"makes":[128],"stay":[131],"inside":[132],"cell":[134],"leading":[135],"depolarisation":[137],"opening":[139],"voltage-dependent":[141],"channels.":[143]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}