{"id":"https://openalex.org/W2403003263","doi":null,"title":"Digital pressure and flow measurement upon local cooling in Raynaud's disease. Effect of naftidrofuryl.","display_name":"Digital pressure and flow measurement upon local cooling in Raynaud's disease. Effect of naftidrofuryl.","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W2403003263","mag":"2403003263","pmid":"https://pubmed.ncbi.nlm.nih.gov/3734514"},"language":"en","primary_location":{"id":"pmid:3734514","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3734514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International angiology : a journal of the International Union of Angiology","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022506186","display_name":"Bounameaux Hm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H M Bounameaux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079200525","display_name":"H. Hellemans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Hellemans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020389324","display_name":"R Verhaege","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Verhaege","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"5","issue":"1","first_page":"39","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/raynaud-s-phenomenon","display_name":"Raynaud's phenomenon","score":0.9990000128746033},{"id":"https://openalex.org/keywords/naftidrofuryl","display_name":"naftidrofuryl","score":0.9120000004768372},{"id":"https://openalex.org/keywords/digital-blood-flow","display_name":"digital blood flow","score":0.5960000157356262},{"id":"https://openalex.org/keywords/cold-provocation-test","display_name":"cold provocation test","score":0.8349999785423279},{"id":"https://openalex.org/keywords/local-cooling","display_name":"local cooling","score":0.824999988079071},{"id":"https://openalex.org/keywords/vasodilator-therapy","display_name":"vasodilator therapy","score":0.7250000238418579},{"id":"https://openalex.org/keywords/subjective-improvement","display_name":"subjective improvement","score":0.367000013589859}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9242812991142273},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7395243644714355},{"id":"https://openalex.org/C110586980","wikidata":"https://www.wikidata.org/wiki/Q4168588","display_name":"Provocation test","level":3,"score":0.7099632024765015},{"id":"https://openalex.org/C2776952691","wikidata":"https://www.wikidata.org/wiki/Q5142470","display_name":"Raynaud's disease","level":2,"score":0.691204309463501},{"id":"https://openalex.org/C2780017030","wikidata":"https://www.wikidata.org/wiki/Q368366","display_name":"Cuff","level":2,"score":0.6072624921798706},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5698423385620117},{"id":"https://openalex.org/C3019079563","wikidata":"https://www.wikidata.org/wiki/Q67173088","display_name":"Skin temperature","level":2,"score":0.49217596650123596},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.44407641887664795},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.35762733221054077},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35623055696487427},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.35442501306533813},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3258516788482666},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.16616672277450562},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07711741328239441},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003080","descriptor_name":"Cold Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005385","descriptor_name":"Fingers","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009257","descriptor_name":"Nafronyl","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011928","descriptor_name":"Raynaud Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011928","descriptor_name":"Raynaud Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012881","descriptor_name":"Skin Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3734514","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3734514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International angiology : a journal of the International Union of Angiology","raw_type":"Clinical Trial"},{"id":"mag:2403003263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3734514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2113684203","https://openalex.org/W2016474039","https://openalex.org/W2066856537","https://openalex.org/W2017658547","https://openalex.org/W2418551166","https://openalex.org/W2402797649","https://openalex.org/W7065167862","https://openalex.org/W2126874694","https://openalex.org/W82185132","https://openalex.org/W2058748479"],"abstract_inverted_index":{"Two":[0],"local":[1],"cold":[2],"provocation":[3],"tests":[4,117],"were":[5],"carried":[6],"out":[7,108],"in":[8,13,34,67,124,163],"25":[9],"healthy":[10,39],"volunteers":[11,40],"and":[12,24,45],"14":[14],"patients":[15,36,69,111,122],"with":[16,112,129,148],"Raynaud's":[17,35,68,113],"disease,":[18],"using":[19],"finger":[20,91],"systolic":[21],"pressure":[22,162],"(FSP)":[23],"digital":[25,52,159],"blood":[26],"flow":[27,53,160],"measurements.":[28],"Mean":[29],"FSP":[30],"was":[31,61,87,103,143,152],"significantly":[32,65],"lower":[33,66],"compared":[37,71],"to":[38,72],"at":[41],"15":[42],"degrees":[43,47,59,96],"C":[44,48],"10":[46],"(cuff":[49],"temperature).":[50],"Maximal":[51],"(at":[54],"skin":[55,92],"temperature":[56,93],"of":[57,94,109,120],"38":[58],"C)":[60],"slightly":[62],"though":[63],"not":[64,153],"as":[70],"normals":[73],"(27":[74],"+/-":[75,79],"3":[76],"versus":[77,134],"36":[78],"4":[80],"ml/100":[81],"ml/min).":[82],"Upon":[83],"cooling,":[84],"statistical":[85],"significance":[86],"reached":[88],"starting":[89],"from":[90],"24":[95],"C.":[97],"Overlap":[98],"between":[99],"the":[100,121,164],"two":[101],"groups":[102],"considerable":[104],"but":[105,150],"only":[106],"1":[107],"13":[110],"disease":[114],"had":[115],"both":[116],"normal.":[118],"Ten":[119],"participated":[123],"a":[125],"double-blind":[126],"cross-over":[127],"trial":[128],"naftidrofuryl":[130,149],"(200":[131],"mg":[132],"t.i.d.)":[133],"placebo.":[135],"Significant":[136],"(p":[137],"less":[138],"than":[139],"0.05)":[140],"subjective":[141],"improvement":[142],"noted":[144],"after":[145],"6":[146],"weeks":[147],"this":[151],"necessarily":[154],"substantiated":[155],"by":[156],"an":[157],"increased":[158],"or":[161],"test":[165],"situation.":[166]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
