{"id":"https://openalex.org/W2402909404","doi":null,"title":"Almotriptan: a review of pharmacology, clinical efficacy, and tolerability.","display_name":"Almotriptan: a review of pharmacology, clinical efficacy, and tolerability.","publication_year":2002,"publication_date":"2002-02-01","ids":{"openalex":"https://openalex.org/W2402909404","mag":"2402909404","pmid":"https://pubmed.ncbi.nlm.nih.gov/11859907"},"language":"en","primary_location":{"id":"pmid:11859907","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11859907","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of managed care","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046692275","display_name":"SeggernRandalL Von","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125728","display_name":"Headache Wellness Center","ror":"https://ror.org/03azk3n24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210125728"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"SeggernRandalL Von","raw_affiliation_strings":["Clinical Research Headache Wellness Center, Greensboro, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Headache Wellness Center, Greensboro, North Carolina, USA","institution_ids":["https://openalex.org/I4210125728"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046692275"],"corresponding_institution_ids":["https://openalex.org/I4210125728"],"apc_list":null,"apc_paid":null,"fwci":0.2171,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.60340426,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"8","issue":"3 Suppl","first_page":"S74","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/almotriptan","display_name":"almotriptan","score":1.0},{"id":"https://openalex.org/keywords/acute-migraine","display_name":"acute migraine","score":0.8920000195503235},{"id":"https://openalex.org/keywords/triptans","display_name":"triptans","score":0.9660000205039978},{"id":"https://openalex.org/keywords/sumatriptan","display_name":"sumatriptan","score":0.8989999890327454},{"id":"https://openalex.org/keywords/migraine-treatment-efficacy","display_name":"migraine treatment efficacy","score":0.6480000019073486},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.859000027179718},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.9330000281333923},{"id":"https://openalex.org/keywords/chest-symptoms","display_name":"chest symptoms","score":0.7429999709129333},{"id":"https://openalex.org/keywords/long-term-treatment-response","display_name":"long-term treatment response","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9467742443084717},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.9175361394882202},{"id":"https://openalex.org/C2778871607","wikidata":"https://www.wikidata.org/wiki/Q416978","display_name":"Sumatriptan","level":4,"score":0.7628594636917114},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.6992315053939819},{"id":"https://openalex.org/C2777119127","wikidata":"https://www.wikidata.org/wiki/Q423866","display_name":"Triptans","level":3,"score":0.6291593313217163},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6067558526992798},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6023553609848022},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5778778791427612},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5011873245239258},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26842594146728516},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.09032446146011353},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014363","descriptor_name":"Tryptamines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017322","descriptor_name":"Clinical Trials, Phase II as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017326","descriptor_name":"Clinical Trials, Phase III as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11859907","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11859907","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of managed care","raw_type":"Journal Article"},{"id":"mag:2402909404","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11859907","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2089574272","https://openalex.org/W2113830524","https://openalex.org/W1991924677","https://openalex.org/W1996823849","https://openalex.org/W2108137675","https://openalex.org/W2126212814","https://openalex.org/W2064666101","https://openalex.org/W2038338738","https://openalex.org/W1982373420","https://openalex.org/W1965322143"],"abstract_inverted_index":{"OBJECTIVE:":[0],"This":[1],"article":[2],"summarizes":[3],"preclinical":[4],"and":[5,25,30,78,112,209,238],"clinical":[6,40],"data":[7],"for":[8,125,192,250],"almotriptan.":[9],"METHODS:":[10],"Almotriptan":[11],"has":[12,140,151,178,219],"been":[13],"evaluated":[14],"in":[15,22,31,34,161],"more":[16,49,190],"than":[17,51,212],"3,500":[18],"acute":[19,254],"migraine":[20],"patients":[21,33,119,166],"phase":[23],"2":[24,65,70,132],"3":[26,110],"double-blind,":[27],"randomized":[28],"trials":[29,41],"1,500":[32],"long-term":[35,115],"open-label":[36],"trials.":[37],"RESULTS:":[38],"Controlled":[39],"show":[42,101,135],"that":[43,102,118,136,184,206],"almotriptan":[44,103,124,137,150,159,177,202,218,242],"12.5":[45,138],"mg":[46,139],"is":[47,87,203],"significantly":[48,210],"effective":[50],"placebo.":[52],"These":[53],"results":[54,113,160],"are":[55],"observed":[56,88],"across":[57,109],"different":[58],"endpoints":[59],"examined,":[60],"including":[61],"pain":[62,85,168],"relief":[63,86,169],"at":[64,69],"hours,":[66,71],"pain-free":[67,80],"outcome":[68],"recurrence":[72],"rate,":[73],"use":[74,157],"of":[75,84,107,158,165,185,197,207,223,234,253],"escape":[76],"medication,":[77],"sustained":[79],"outcome.":[81],"The":[82,195],"onset":[83],"as":[89,91],"early":[90,193],"30":[92],"minutes":[93],"after":[94],"administration.":[95,194],"Results":[96,130],"from":[97,114,131,173],"a":[98,105,152,162,179,220,244],"multiple-attack":[99],"study":[100],"maintains":[104],"consistency":[106],"response":[108],"attacks,":[111],"studies":[116,134],"confirm":[117],"continue":[120],"to":[121,123,127,143,183,205],"respond":[122],"up":[126],"1":[128],"year.":[129],"comparative":[133],"comparable":[141,182,204,236],"efficacy":[142,237],"sumatriptan":[144],"50":[145],"or":[146,170],"100":[147],"mg,":[148],"but":[149],"superior":[153,239],"tolerability":[154,180,240],"profile.":[155],"Early":[156],"higher":[163],"proportion":[164],"achieving":[167],"complete":[171],"freedom":[172],"pain.":[174],"CONCLUSIONS:":[175],"Because":[176,233],"profile":[181],"placebo,":[186],"it":[187],"may":[188],"be":[189],"acceptable":[191],"incidence":[196,222],"treatment-related":[198],"adverse":[199,227],"events":[200],"with":[201,214,230],"placebo":[208],"lower":[211],"recorded":[213],"sumatriptan.":[215],"In":[216],"addition,":[217],"low":[221],"chest":[224],"symptoms,":[225],"an":[226],"event":[228],"associated":[229],"triptan":[231],"use.":[232],"its":[235],"profile,":[241],"offers":[243],"potential":[245],"improvement":[246],"over":[247],"existing":[248],"triptans":[249],"the":[251],"treatment":[252],"migraine.":[255]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
