{"id":"https://openalex.org/W2402867314","doi":null,"title":"YES oncogenic activity is specified by its SH4 domain and regulates RAS/MAPK signaling in colon carcinoma cells.","display_name":"YES oncogenic activity is specified by its SH4 domain and regulates RAS/MAPK signaling in colon carcinoma cells.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2402867314","mag":"2402867314","pmid":"https://pubmed.ncbi.nlm.nih.gov/26269757","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4529617"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3510818","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4529617","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4529617","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Fanny Dubois","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210113016","display_name":"Centre de Recherche en Biologie cellulaire de Montpellier","ror":"https://ror.org/01xpc6869","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210113016"]},{"id":"https://openalex.org/I4210156758","display_name":"Institut de G\u00e9nomique Fonctionnelle","ror":"https://ror.org/043wmc583","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210156758"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fanny Dubois","raw_affiliation_strings":["CNRS UMR5237, University of Montpellier, CRBM 1919 Route de Mende, 34000 Montpellier, France ; CNRS, UMR5203 CNRS, INSERM U661 University of Montpellier, IGF 34000 Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS UMR5237, University of Montpellier, CRBM 1919 Route de Mende, 34000 Montpellier, France ; CNRS, UMR5203 CNRS, INSERM U661 University of Montpellier, IGF 34000 Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210113016","https://openalex.org/I4210156758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029784439","display_name":"C\u00e9dric Leroy","orcid":"https://orcid.org/0000-0002-0104-6591","observed_orcids":["https://orcid.org/0000-0002-0104-6591"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210113016","display_name":"Centre de Recherche en Biologie cellulaire de Montpellier","ror":"https://ror.org/01xpc6869","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210113016"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9dric Leroy","raw_affiliation_strings":["CNRS UMR5237, University of Montpellier, CRBM 1919 Route de Mende, 34000 Montpellier, France ; Novartis CH-4002 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS UMR5237, University of Montpellier, CRBM 1919 Route de Mende, 34000 Montpellier, France ; Novartis CH-4002 Basel, Switzerland","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210113016"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Val\u00e9rie Simon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210113016","display_name":"Centre de Recherche en Biologie cellulaire de Montpellier","ror":"https://ror.org/01xpc6869","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210113016"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Val\u00e9rie Simon","raw_affiliation_strings":["CNRS UMR5237, University of Montpellier, CRBM 1919 Route de Mende, 34000 Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS UMR5237, University of Montpellier, CRBM 1919 Route de Mende, 34000 Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210113016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102824631","display_name":"Christine B\u00e9nistant","orcid":"https://orcid.org/0000-0002-4620-4768","observed_orcids":["https://orcid.org/0000-0002-4620-4768"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210100279","display_name":"Centre de Biologie Structurale","ror":"https://ror.org/0189yvq06","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210100279"]},{"id":"https://openalex.org/I4210113016","display_name":"Centre de Recherche en Biologie cellulaire de Montpellier","ror":"https://ror.org/01xpc6869","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210113016"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christine Benistant","raw_affiliation_strings":["CNRS UMR5237, University of Montpellier, CRBM 1919 Route de Mende, 34000 Montpellier, France ; CNRS, UMR5048 CNRS, INSERM U1048, University of Montpellier, CBS 34000 Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS UMR5237, University of Montpellier, CRBM 1919 Route de Mende, 34000 Montpellier, France ; CNRS, UMR5048 CNRS, INSERM U1048, University of Montpellier, CBS 34000 Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210100279","https://openalex.org/I4210113016"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076971191","display_name":"Serge Roche","orcid":"https://orcid.org/0000-0003-3413-3859","observed_orcids":["https://orcid.org/0000-0003-3413-3859"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210113016","display_name":"Centre de Recherche en Biologie cellulaire de Montpellier","ror":"https://ror.org/01xpc6869","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210113016"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Serge Roche","raw_affiliation_strings":["CNRS UMR5237, University of Montpellier, CRBM 1919 Route de Mende, 34000 Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS UMR5237, University of Montpellier, CRBM 1919 Route de Mende, 34000 Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210113016"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4612,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.57471224,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"5","issue":"6","first_page":"1972","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/yes-kinase","display_name":"Yes kinase","score":0.9390000104904175},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.8190000057220459},{"id":"https://openalex.org/keywords/protein-palmitoylation","display_name":"palmitoylation","score":0.9459999799728394},{"id":"https://openalex.org/keywords/ras-mapk-pathway","display_name":"RAS/MAPK pathway","score":0.9639999866485596},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9200000166893005},{"id":"https://openalex.org/keywords/oncogenic-signaling","display_name":"oncogenic signaling","score":0.7649999856948853},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.8709999918937683},{"id":"https://openalex.org/keywords/shc","display_name":"Shc","score":0.9860000014305115},{"id":"https://openalex.org/keywords/shp2","display_name":"SHP2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C146727910","wikidata":"https://www.wikidata.org/wiki/Q501620","display_name":"Palmitoylation","level":4,"score":0.7873325347900391},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.6633608341217041},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6305562853813171},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5965433120727539},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5965155363082886},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5587093234062195},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5264887809753418},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.516007661819458},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.5102255344390869},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5060400366783142},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4981083869934082},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.46812617778778076},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.45426860451698303},{"id":"https://openalex.org/C177917778","wikidata":"https://www.wikidata.org/wiki/Q14905188","display_name":"GRB2","level":4,"score":0.4478427767753601},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.41078120470046997},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28114053606987},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1287420094013214},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10192057490348816},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06912389397621155},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3510818","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4529617","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26269757","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26269757","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4529617","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4529617/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-01883466v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-01883466","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Cancer Research, 2015, 5 (6), pp.1972--1987","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3510818","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4529617","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W116685234","https://openalex.org/W1522460523","https://openalex.org/W1532635242","https://openalex.org/W1680396314","https://openalex.org/W1862926318","https://openalex.org/W1863498511","https://openalex.org/W1965878299","https://openalex.org/W1973400979","https://openalex.org/W1981012538","https://openalex.org/W1986977142","https://openalex.org/W1988787904","https://openalex.org/W1992108472","https://openalex.org/W1992737970","https://openalex.org/W1992873952","https://openalex.org/W1996894304","https://openalex.org/W2003074638","https://openalex.org/W2003380134","https://openalex.org/W2006560015","https://openalex.org/W2007390895","https://openalex.org/W2020031759","https://openalex.org/W2020240239","https://openalex.org/W2021181797","https://openalex.org/W2028986871","https://openalex.org/W2030629677","https://openalex.org/W2054695840","https://openalex.org/W2055624262","https://openalex.org/W2055943378","https://openalex.org/W2057711788","https://openalex.org/W2057803993","https://openalex.org/W2060544488","https://openalex.org/W2061229454","https://openalex.org/W2068981707","https://openalex.org/W2069180517","https://openalex.org/W2070934834","https://openalex.org/W2079961202","https://openalex.org/W2085039090","https://openalex.org/W2097024842","https://openalex.org/W2101257013","https://openalex.org/W2110176960","https://openalex.org/W2115012961","https://openalex.org/W2131794175","https://openalex.org/W2131856634","https://openalex.org/W2141071568","https://openalex.org/W2145842550","https://openalex.org/W2147650118","https://openalex.org/W2153720194","https://openalex.org/W2158974373","https://openalex.org/W2166394159","https://openalex.org/W2166576553","https://openalex.org/W2171312409","https://openalex.org/W2171629680"],"related_works":["https://openalex.org/W2143588401","https://openalex.org/W2057803993","https://openalex.org/W1038602703","https://openalex.org/W3138806559","https://openalex.org/W4387705672","https://openalex.org/W2229800306","https://openalex.org/W2327707625","https://openalex.org/W4247022838","https://openalex.org/W2034385303","https://openalex.org/W4246542553"],"abstract_inverted_index":{"Members":[0],"of":[1,5,64,78,88,96,107,138,156,195,208],"the":[2,48,79,93,104,154,189,193,206],"SRC":[3,97,101,151],"family":[4],"tyrosine":[6,127],"kinases":[7,128],"(SFK)":[8],"display":[9],"important":[10,33],"functions":[11],"in":[12,19,52,72,92,109,192,205,211],"human":[13],"cancer,":[14],"but":[15],"their":[16],"specific":[17],"role":[18,187,202],"tumorigenesis":[20],"remains":[21],"unclear.":[22],"We":[23,55],"previously":[24],"demonstrated":[25],"that":[26,39,57,68,120,175],"YES":[27,58,70,83,111,131,133,165,179,204],"regulates":[28],"a":[29,89,185,200],"unique":[30],"oncogenic":[31,59,197],"signaling":[32,60,210],"for":[34,100,188,203],"colorectal":[35],"cancer":[36],"(CRC)":[37],"progression":[38],"is":[40],"not":[41,148],"shared":[42],"with":[43],"SRC.":[44],"Here,":[45],"we":[46],"addressed":[47],"underlying":[49],"mechanism":[50],"involved":[51],"this":[53],"process.":[54],"show":[56],"relies":[61],"on":[62],"palmitoylation":[63,80,90],"its":[65],"SH4":[66,94,190],"domain":[67,95,191],"controls":[69],"localization":[71],"cholesterol-enriched":[73],"membrane":[74],"micro-domains.":[75],"Specifically,":[76],"deletion":[77],"site":[81,91],"compromised":[82],"transforming":[84,105],"activity,":[85],"while":[86,167],"addition":[87],"was":[98,162,176],"sufficient":[99],"to":[102,153],"restore":[103],"properties":[106],"cells":[108],"which":[110,146],"had":[112],"been":[113],"silenced.":[114],"Subsequently,":[115],"SILAC":[116],"phosphoproteomic":[117],"analysis":[118],"revealed":[119],"micro-domain-associated":[121],"cell":[122,173],"adhesive":[123],"components":[124],"and":[125,144,199],"receptor":[126],"are":[129],"major":[130],"substrates.":[132],"also":[134],"phosphorylates":[135],"upstream":[136],"regulators":[137],"RAS/MAPK":[139,209],"signaling,":[140],"including":[141],"EGFR,":[142],"SHC":[143],"SHP2,":[145],"were":[147],"targeted":[149],"by":[150,164],"due":[152],"absence":[155],"palmitoylation.":[157],"Accordingly,":[158],"EGFR-induced":[159],"MAPK":[160],"activity":[161,170,198],"attenuated":[163],"down-regulation,":[166],"increased":[168],"RAS":[169],"significantly":[171],"restored":[172],"transformation":[174],"lost":[177],"upon":[178],"silencing.":[180],"Collectively,":[181],"these":[182],"results":[183],"uncover":[184],"critical":[186],"specification":[194],"SFK":[196],"selective":[201],"induction":[207],"CRC":[212],"cells.":[213]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
