{"id":"https://openalex.org/W2402857166","doi":"https://doi.org/10.1248/yakushi1947.102.4_365","title":"Synthesis and Antiinflammatory Activity of Hydrocortisone 17, 21-Diesters","display_name":"Synthesis and Antiinflammatory Activity of Hydrocortisone 17, 21-Diesters","publication_year":1982,"publication_date":"1982-01-01","ids":{"openalex":"https://openalex.org/W2402857166","doi":"https://doi.org/10.1248/yakushi1947.102.4_365","mag":"2402857166","pmid":"https://pubmed.ncbi.nlm.nih.gov/7131252"},"language":"ja","primary_location":{"id":"doi:10.1248/yakushi1947.102.4_365","doi":"https://doi.org/10.1248/yakushi1947.102.4_365","is_oa":true,"landing_page_url":"https://doi.org/10.1248/yakushi1947.102.4_365","pdf_url":"https://www.jstage.jst.go.jp/article/yakushi1947/102/4/102_4_365/_pdf","source":{"id":"https://openalex.org/S2764386467","display_name":"YAKUGAKU ZASSHI","issn_l":"0031-6903","issn":["0031-6903","1347-5231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"YAKUGAKU ZASSHI","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/yakushi1947/102/4/102_4_365/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005231544","display_name":"K. SOTA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KAORU SOTA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005779493","display_name":"MORIHIRO MITSUKUCHI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MORIHIRO MITSUKUCHI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082012825","display_name":"JOZI NAKAGAMI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JOZI NAKAGAMI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011661346","display_name":"YASUHIDE TACHI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"YASUHIDE TACHI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053617301","display_name":"Jiro Sawada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JIRO SAWADA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113754408","display_name":"Susumu Otomo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SUSUMU OTOMO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004306028","display_name":"Masahiro OHZEKI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MASAHIRO OHZEKI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5615,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.64555315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"102","issue":"4","first_page":"365","last_page":"370"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.4580000042915344,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.4580000042915344,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.19699999690055847,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.10100000351667404,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8600000143051147},{"id":"https://openalex.org/keywords/corticosteroid-derivatives","display_name":"corticosteroid derivatives","score":0.6859999895095825},{"id":"https://openalex.org/keywords/betamethasone-17-valerate","display_name":"betamethasone 17-valerate","score":0.9520000219345093},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2778709874","wikidata":"https://www.wikidata.org/wiki/Q190875","display_name":"Hydrocortisone","level":2,"score":0.7957166433334351},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.663184642791748},{"id":"https://openalex.org/C2781162121","wikidata":"https://www.wikidata.org/wiki/Q416132","display_name":"Betamethasone","level":2,"score":0.6630153059959412},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6544156074523926},{"id":"https://openalex.org/C2780014933","wikidata":"https://www.wikidata.org/wiki/Q422956","display_name":"Propionate","level":2,"score":0.6212054491043091},{"id":"https://openalex.org/C2778942509","wikidata":"https://www.wikidata.org/wiki/Q456053","display_name":"Croton oil","level":3,"score":0.5913572907447815},{"id":"https://openalex.org/C2776804153","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Corticosteroid","level":2,"score":0.4169290065765381},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29864180088043213},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23924881219863892},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23171541094779968},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2130834460258484},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.06357446312904358}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1248/yakushi1947.102.4_365","doi":"https://doi.org/10.1248/yakushi1947.102.4_365","is_oa":true,"landing_page_url":"https://doi.org/10.1248/yakushi1947.102.4_365","pdf_url":"https://www.jstage.jst.go.jp/article/yakushi1947/102/4/102_4_365/_pdf","source":{"id":"https://openalex.org/S2764386467","display_name":"YAKUGAKU ZASSHI","issn_l":"0031-6903","issn":["0031-6903","1347-5231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"YAKUGAKU ZASSHI","raw_type":"journal-article"},{"id":"pmid:7131252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7131252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","raw_type":"English Abstract"}],"best_oa_location":{"id":"doi:10.1248/yakushi1947.102.4_365","doi":"https://doi.org/10.1248/yakushi1947.102.4_365","is_oa":true,"landing_page_url":"https://doi.org/10.1248/yakushi1947.102.4_365","pdf_url":"https://www.jstage.jst.go.jp/article/yakushi1947/102/4/102_4_365/_pdf","source":{"id":"https://openalex.org/S2764386467","display_name":"YAKUGAKU ZASSHI","issn_l":"0031-6903","issn":["0031-6903","1347-5231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"YAKUGAKU ZASSHI","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.766700029373169}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2402857166.pdf","grobid_xml":"https://content.openalex.org/works/W2402857166.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2042567861","https://openalex.org/W2952747550","https://openalex.org/W2317595376","https://openalex.org/W2034347092","https://openalex.org/W2952628837","https://openalex.org/W2044829512","https://openalex.org/W2017162613","https://openalex.org/W2471227563","https://openalex.org/W2032491709","https://openalex.org/W2328534180"],"abstract_inverted_index":{"A":[0],"new":[1],"series":[2],"of":[3],"hydrocortisone":[4,30],"17,":[5],"21-diesters":[6],"was":[7,13,29,34],"prepared":[8],"and":[9],"their":[10],"antiinflammatory":[11],"activity":[12],"evaluated":[14],"by":[15],"the":[16],"croton":[17],"oil":[18],"ear":[19],"edema":[20],"inhibition":[21],"test":[22],"in":[23],"rats.":[24],"The":[25],"most":[26],"potent":[27],"compound":[28],"17-butyrate":[31],"21-propionate":[32],"which":[33],"more":[35],"active":[36],"than":[37],"betamethasone":[38],"17-valerate.":[39]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
