{"id":"https://openalex.org/W2402803154","doi":null,"title":"Effect of interferon and lymphokines on lymphocytes.","display_name":"Effect of interferon and lymphokines on lymphocytes.","publication_year":1977,"publication_date":"1977-01-01","ids":{"openalex":"https://openalex.org/W2402803154","mag":"2402803154","pmid":"https://pubmed.ncbi.nlm.nih.gov/358461"},"language":"en","primary_location":{"id":"pmid:358461","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/358461","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Texas reports on biology and medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039968774","display_name":"George E. Gifford","orcid":"https://orcid.org/0000-0002-0156-6917","observed_orcids":["https://orcid.org/0000-0002-0156-6917"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G E Gifford","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005532411","display_name":"M Tobey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Tobey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3494,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.55970626,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":null,"first_page":"375","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.6304000020027161,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.6304000020027161,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.2451999932527542,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.051600001752376556,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.9670000076293945},{"id":"https://openalex.org/keywords/lymphokines","display_name":"lymphokines","score":1.0},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.828000009059906},{"id":"https://openalex.org/keywords/soluble-mediators","display_name":"soluble mediators","score":0.6430000066757202},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C49382859","wikidata":"https://www.wikidata.org/wiki/Q286498","display_name":"Lymphokine","level":3,"score":0.9896560311317444},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.6514967083930969},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5928183197975159},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5248280167579651},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4963546395301819},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44173556566238403},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35084307193756104}],"mesh":[{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:358461","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/358461","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Texas reports on biology and medicine","raw_type":"Journal Article"},{"id":"mag:2402803154","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/358461","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4211261634","https://openalex.org/W2411813885","https://openalex.org/W2087328054","https://openalex.org/W137027726","https://openalex.org/W2418143730","https://openalex.org/W2409463314","https://openalex.org/W2048379828","https://openalex.org/W2039535629","https://openalex.org/W4211137556","https://openalex.org/W4405328696"],"abstract_inverted_index":{"We":[0,23],"have":[1,24,30],"reviewed":[2],"some":[3],"of":[4,7,12,41,86,110],"the":[5,9,13,84,99,108],"functions":[6,31,59],"lymphokines,":[8,57],"soluble":[10],"mediators":[11],"cellular":[14,100],"immune":[15],"response,":[16],"which":[17,29],"are":[18,60,65],"produced":[19],"by":[20,67],"lymphoid":[21],"cells.":[22],"particularily":[25],"emphasized":[26],"those":[27,34],"lymphokines":[28],"similar":[32],"to":[33,94,106],"reported":[35],"for":[36],"interferon.":[37],"Interferon":[38],"is":[39,91],"capable":[40],"both":[42,98],"amplifying":[43],"and":[44,74,101],"depressing":[45],"cell":[46],"mediated":[47],"immunological":[48],"reactions":[49],"in":[50,62,70,104],"a":[51],"dose":[52],"dependent":[53],"fashion.":[54],"The":[55],"other":[56],"whose":[58],"implicit":[61],"their":[63,68],"names,":[64],"identified":[66],"activities":[69],"various":[71],"assay":[72],"systems":[73],"thus":[75],"there":[76,90],"may":[77],"be":[78,95],"fewer":[79],"actual":[80],"molecular":[81,102],"species":[82],"than":[83],"list":[85],"factors":[87],"implies.":[88],"Obviously,":[89],"much":[92],"work":[93],"done":[96],"at":[97],"levels":[103],"order":[105],"elucidate":[107],"mechanism":[109],"lymphokine":[111],"function.":[112]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}