{"id":"https://openalex.org/W2402736308","doi":null,"title":"NDF/heregulin activates MAP kinase and p70/p85 S6 kinase during proliferation or differentiation of mammary epithelial cells.","display_name":"NDF/heregulin activates MAP kinase and p70/p85 S6 kinase during proliferation or differentiation of mammary epithelial cells.","publication_year":1995,"publication_date":"1995-01-05","ids":{"openalex":"https://openalex.org/W2402736308","mag":"2402736308","pmid":"https://pubmed.ncbi.nlm.nih.gov/7824269"},"language":"en","primary_location":{"id":"pmid:7824269","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7824269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045884063","display_name":"Barbara M. Marte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I860889466","display_name":"Friedrich Miescher Institute","ror":"https://ror.org/01bmjkv45","country_code":"CH","type":"facility","lineage":["https://openalex.org/I860889466"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"B M Marte","raw_affiliation_strings":["Friedrich-Miescher-Institute, Basel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Friedrich-Miescher-Institute, Basel","institution_ids":["https://openalex.org/I860889466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079659004","display_name":"Diana Graus-Porta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Graus-Porta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003138012","display_name":"Marc G. Jeschke","orcid":"https://orcid.org/0000-0003-0870-1664","observed_orcids":["https://orcid.org/0000-0003-0870-1664"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Jeschke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011479527","display_name":"Doriano Fabbro","orcid":"https://orcid.org/0000-0002-9400-4517","observed_orcids":["https://orcid.org/0000-0002-9400-4517"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Fabbro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023604575","display_name":"Nancy E. Hynes","orcid":"https://orcid.org/0000-0001-8802-2316","observed_orcids":["https://orcid.org/0000-0001-8802-2316"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N E Hynes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012376450","display_name":"Daniela Taverna","orcid":"https://orcid.org/0000-0002-6365-527X","observed_orcids":["https://orcid.org/0000-0002-6365-527X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Taverna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.7391,"has_fulltext":false,"cited_by_count":98,"citation_normalized_percentile":{"value":0.97783487,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"10","issue":"1","first_page":"167","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neu-differentiation-factor","display_name":"neu differentiation factor","score":0.828000009059906},{"id":"https://openalex.org/keywords/neuregulin-1","display_name":"neuregulin-1","score":0.949999988079071},{"id":"https://openalex.org/keywords/mammary-epithelial-cells","display_name":"mammary epithelial cells","score":0.843999981880188},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.7680000066757202},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9100000262260437},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.5379999876022339},{"id":"https://openalex.org/keywords/t47d-cells","display_name":"T47D cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hc11-cells","display_name":"HC11 cells","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7215179204940796},{"id":"https://openalex.org/C2779251935","wikidata":"https://www.wikidata.org/wiki/Q5385089","display_name":"ErbB","level":3,"score":0.6806172132492065},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5992563366889954},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.52329021692276},{"id":"https://openalex.org/C104202773","wikidata":"https://www.wikidata.org/wiki/Q18031289","display_name":"P70-S6 Kinase 1","level":4,"score":0.4843672215938568},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.44883012771606445},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4475767910480499},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.4297621548175812},{"id":"https://openalex.org/C185323287","wikidata":"https://www.wikidata.org/wiki/Q59252204","display_name":"Neuregulin","level":3,"score":0.4100167155265808},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3850363492965698},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.10498523712158203}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019893","descriptor_name":"Ribosomal Protein S6 Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020880","descriptor_name":"Neuregulins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:7824269","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7824269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unito.it:2318/23523","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/23523","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2402736308","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7824269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2325551048","https://openalex.org/W2014681972","https://openalex.org/W189410234","https://openalex.org/W2123184189","https://openalex.org/W1538489297","https://openalex.org/W2408681326","https://openalex.org/W1986335023","https://openalex.org/W2129520059","https://openalex.org/W1967121646","https://openalex.org/W2171466517"],"abstract_inverted_index":{"Neu":[0],"differentiation":[1,146],"factors":[2,10],"(NDF)":[3],"are":[4,44,73],"a":[5,106],"novel":[6],"family":[7],"of":[8,85,108,112,147,178],"polypeptide":[9],"which":[11,43,55,157],"activate":[12,99],"sub-class":[13],"I":[14],"tyrosine":[15,77],"kinase":[16,63,72,83,130],"receptors.":[17],"In":[18,40,141],"all":[19],"mammary":[20,148],"epithelial":[21,149],"cells":[22,42,54],"analysed":[23],"in":[24,50,57,81,101],"this":[25],"study,":[26],"NDF":[27,75,93,151,174],"activates":[28],"the":[29,61,69,80,124,127,169],"same":[30,133],"signalling":[31,155],"pathways":[32,156],"while":[33],"it":[34],"induces":[35],"different,":[36],"cell-specific":[37],"biological":[38,170],"effects.":[39],"AU565":[41,138],"growth":[45,144],"inhibited,":[46],"as":[47,49],"well":[48],"T47D":[51,102],"or":[52,117,145],"HC11":[53],"proliferate":[56],"response":[58],"to":[59,98,105],"NDF,":[60],"MAP":[62],"isoforms":[64],"p44ERK1":[65],"and":[66,68,79,126],"p42ERK2":[67],"p70/p85":[70,128],"S6":[71,129],"activated.":[74],"stimulates":[76,122,152],"phosphorylation":[78],"vitro":[82],"activity":[84],"ErbB-2.":[86,179],"When":[87],"PKC":[88,166],"is":[89,94],"activated":[90],"by":[91,114,118,162,173],"TPA,":[92],"no":[95],"longer":[96],"able":[97],"ErbB-2":[100,113,163],"cells,":[103,150],"leading":[104],"blockage":[107],"cell":[109,139],"proliferation.":[110],"Activation":[111],"point":[115],"mutation,":[116],"monoclonal":[119,134],"antibodies,":[120],"also":[121,159],"both":[123],"MAPK":[125],"pathways.":[131],"The":[132],"antibodies":[135],"can":[136,158],"induce":[137],"differentiation.":[140],"summary,":[142],"during":[143],"several":[153],"independent":[154],"be":[160],"triggered":[161],"stimulation":[164],"alone.":[165],"activation":[167],"blocks":[168],"effect":[171],"induced":[172],"through":[175],"negative":[176],"modulation":[177]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}