{"id":"https://openalex.org/W2402705035","doi":null,"title":"APOE polymorphism as a potential determinant of functional fitness in the elderly regardless of nutritional status.","display_name":"APOE polymorphism as a potential determinant of functional fitness in the elderly regardless of nutritional status.","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2402705035","mag":"2402705035","pmid":"https://pubmed.ncbi.nlm.nih.gov/22101883"},"language":"en","primary_location":{"id":"pmid:22101883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22101883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000359677","display_name":"Michaela \u0160nejdrlov\u00e1","orcid":"https://orcid.org/0000-0003-1087-9795","observed_orcids":["https://orcid.org/0000-0003-1087-9795"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Michaela Snejdrlova","raw_affiliation_strings":["3rd Department of Internal Medicine, 1st Faculty of Medicine, Charles University Prague, Czech Republic. Michaela.Snejdrlova@vfn.cz","3rd Dept, of Internal Medicine, 1st Faculty of Medicine, Charles University, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3rd Department of Internal Medicine, 1st Faculty of Medicine, Charles University Prague, Czech Republic. Michaela.Snejdrlova@vfn.cz","institution_ids":["https://openalex.org/I21250087"]},{"raw_affiliation_string":"3rd Dept, of Internal Medicine, 1st Faculty of Medicine, Charles University, Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032935544","display_name":"Zden\u011bk Kalvach","orcid":"https://orcid.org/0000-0003-0598-4603","observed_orcids":["https://orcid.org/0000-0003-0598-4603"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zdenek Kalvach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001426580","display_name":"Eva Topinkov\u00e1","orcid":"https://orcid.org/0000-0002-6786-4116","observed_orcids":["https://orcid.org/0000-0002-6786-4116"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eva Topinkova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086863186","display_name":"Michal Vrabl\u00edk","orcid":"https://orcid.org/0000-0002-7226-1926","observed_orcids":["https://orcid.org/0000-0002-7226-1926"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michal Vrablik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090293257","display_name":"R Proch\u00e1zkov\u00e1","orcid":"https://orcid.org/0000-0002-8649-996X","observed_orcids":["https://orcid.org/0000-0002-8649-996X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Renata Prochazkova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048073441","display_name":"M Kvasilov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marie Kvasilova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025847251","display_name":"V\u011bra L\u00e1nsk\u00e1","orcid":"https://orcid.org/0000-0002-2832-5689","observed_orcids":["https://orcid.org/0000-0002-2832-5689"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vera Lanska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011068355","display_name":"Luk\u00e1\u0161 Zlatohl\u00e1vek","orcid":"https://orcid.org/0000-0001-6550-2587","observed_orcids":["https://orcid.org/0000-0001-6550-2587"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lukas Zlatohlavek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109172431","display_name":"Martina Prus\u00edkov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martina Prusikova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5017005943","display_name":"R \u010ce\u0161ka","orcid":"https://orcid.org/0000-0002-2541-5179","observed_orcids":["https://orcid.org/0000-0002-2541-5179"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Ceska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0451,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.79039244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"32 Suppl 2","issue":null,"first_page":"51","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.3935999870300293,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.3935999870300293,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance","score":0.13130000233650208,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.07800000160932541,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.8740000128746033},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.8709999918937683},{"id":"https://openalex.org/keywords/apoe-polymorphism","display_name":"APOE polymorphism","score":0.8479999899864197},{"id":"https://openalex.org/keywords/functional-fitness","display_name":"functional fitness","score":0.871999979019165},{"id":"https://openalex.org/keywords/frailty","display_name":"frailty","score":0.906000018119812},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.6549999713897705},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.7250000238418579},{"id":"https://openalex.org/keywords/nutritional-status","display_name":"nutritional status","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.8835016489028931},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6419119834899902},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.5676634907722473},{"id":"https://openalex.org/C133925201","wikidata":"https://www.wikidata.org/wiki/Q188419","display_name":"Life expectancy","level":3,"score":0.539014995098114},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5272321105003357},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5160722136497498},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5093656778335571},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5053203701972961},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.45232754945755005},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3704115152359009},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.34833118319511414},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2802240252494812},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2616943120956421},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1752167046070099},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.108440101146698},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.07961875200271606}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008017","descriptor_name":"Life Expectancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009752","descriptor_name":"Nutritional Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010809","descriptor_name":"Physical Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053318","descriptor_name":"Apolipoprotein E3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053329","descriptor_name":"Apolipoprotein E2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22101883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22101883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},{"id":"mag:2402705035","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22101883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W142363866","https://openalex.org/W2017581860","https://openalex.org/W2031918005","https://openalex.org/W2042885626","https://openalex.org/W2051394059","https://openalex.org/W2060803759","https://openalex.org/W2066644955","https://openalex.org/W2071474110","https://openalex.org/W2098713111","https://openalex.org/W2106611664","https://openalex.org/W2109206948","https://openalex.org/W2112519660","https://openalex.org/W2114656311","https://openalex.org/W2129700906","https://openalex.org/W2138946592","https://openalex.org/W2164059021","https://openalex.org/W2164186760","https://openalex.org/W2166268538","https://openalex.org/W2181444232","https://openalex.org/W4404287881"],"related_works":["https://openalex.org/W7135962564","https://openalex.org/W3096914258","https://openalex.org/W2034294534","https://openalex.org/W2112266520","https://openalex.org/W2151483902","https://openalex.org/W2064507111","https://openalex.org/W2066901330","https://openalex.org/W2293730874","https://openalex.org/W3043306957","https://openalex.org/W2146810586"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Life":[1],"expectancy":[2],"is":[3,21],"determined":[4],"by":[5,96],"a":[6,17,57,69],"combination":[7],"of":[8,37,43,60,66,71,135,172],"genetic":[9,19,150],"predisposition":[10],"(~25%)":[11],"and":[12,46,79],"environmental":[13],"influences":[14],"(~75%).":[15],"Nevertheless":[16],"stronger":[18],"influence":[20],"anticipated":[22],"in":[23,49,155],"long-living":[24],"individuals.":[25,141],"Apolipoprotein":[26],"E":[27],"(APOE)":[28],"gene":[29,103,144],"belongs":[30],"among":[31],"the":[32,41,50,80,128,156,169],"most":[33],"studied":[34],"candidate":[35],"genes":[36],"longevity.":[38],"We":[39,55],"evaluated":[40],"relation":[42],"APOE":[44,102,143],"polymorphism":[45,104,145],"fitness":[47,75,117],"status":[48,76,118,171],"elderly.":[51,157],"MATERIAL":[52],"AND":[53],"METHODS:":[54],"examined":[56],"total":[58],"number":[59],"128":[61],"subjects,":[62],"over":[63],"80":[64],"years":[65],"age.":[67],"Using":[68],"battery":[70],"functional":[72,86,136,170],"tests":[73],"their":[74],"was":[77,94,105],"assessed":[78],"subjects":[81],"were":[82],"stratified":[83],"into":[84],"5":[85],"categories":[87],"according":[88],"to":[89,120,139,152,162],"Spirduso\u00b4s":[90],"classification.":[91],"Biochemistry":[92],"analysis":[93,126],"performed":[95,107],"enzymatic":[97],"method":[98],"using":[99,108],"automated":[100],"analyzers.":[101],"analysed":[106],"PCR-RFLP.":[109],"RESULTS:":[110],"APOE4":[111,129,173],"allele":[112],"carriers":[113,130,160,174],"had":[114,131],"significantly":[115],"worse":[116],"compared":[119,138],"non-carriers":[121],"(p=0.025).":[122],"Multiple":[123],"logistic":[124],"regression":[125],"showed":[127],"higher":[132,167],"risk":[133],"(p=0.05)":[134],"unfitness":[137],"APOE2/E3":[140],"CONCLUSIONS:":[142],"seems":[146],"be":[147],"an":[148],"important":[149],"contributor":[151],"frailty":[153],"development":[154],"While":[158],"APOE2":[159],"tend":[161],"remain":[163],"functionally":[164],"fit":[165],"till":[166],"age,":[168],"deteriorates":[175],"more":[176],"rapidly.":[177]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
