{"id":"https://openalex.org/W2402651979","doi":"https://doi.org/10.1080/03007995.2016.1187119","title":"Efficacy of flurbiprofen 8.75 mg lozenge in patients with a swollen and inflamed sore throat","display_name":"Efficacy of flurbiprofen 8.75 mg lozenge in patients with a swollen and inflamed sore throat","publication_year":2016,"publication_date":"2016-05-05","ids":{"openalex":"https://openalex.org/W2402651979","doi":"https://doi.org/10.1080/03007995.2016.1187119","mag":"2402651979","pmid":"https://pubmed.ncbi.nlm.nih.gov/27146963"},"language":"en","primary_location":{"id":"doi:10.1080/03007995.2016.1187119","doi":"https://doi.org/10.1080/03007995.2016.1187119","is_oa":false,"landing_page_url":"https://doi.org/10.1080/03007995.2016.1187119","pdf_url":null,"source":{"id":"https://openalex.org/S206643269","display_name":"Current Medical Research and Opinion","issn_l":"0300-7995","issn":["0300-7995","1473-4877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Research and Opinion","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073049066","display_name":"Sue Aspley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115825","display_name":"Reckitt Benckiser (United Kingdom)","ror":"https://ror.org/01g87hr29","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210115825"]},{"id":"https://openalex.org/I4405268051","display_name":"Reckitt Benckiser Health Limited (United Kingdom)","ror":"https://ror.org/05jqjhm27","country_code":"GB","type":"company","lineage":["https://openalex.org/I4405268051"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sue Aspley","raw_affiliation_strings":["Reckitt Benckiser Healthcare International Ltd, Slough, Berkshire, UK;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reckitt Benckiser Healthcare International Ltd, Slough, Berkshire, UK;","institution_ids":["https://openalex.org/I4210115825","https://openalex.org/I4405268051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085088033","display_name":"Adrian Shephard","orcid":"https://orcid.org/0000-0002-4020-1486","observed_orcids":["https://orcid.org/0000-0002-4020-1486"]},"institutions":[{"id":"https://openalex.org/I4210115825","display_name":"Reckitt Benckiser (United Kingdom)","ror":"https://ror.org/01g87hr29","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210115825"]},{"id":"https://openalex.org/I4405268051","display_name":"Reckitt Benckiser Health Limited (United Kingdom)","ror":"https://ror.org/05jqjhm27","country_code":"GB","type":"company","lineage":["https://openalex.org/I4405268051"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Adrian Shephard","raw_affiliation_strings":["Reckitt Benckiser Healthcare International Ltd, Slough, Berkshire, UK;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reckitt Benckiser Healthcare International Ltd, Slough, Berkshire, UK;","institution_ids":["https://openalex.org/I4210115825","https://openalex.org/I4405268051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108391604","display_name":"E. Schachtel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emily Schachtel","raw_affiliation_strings":["Schachtel Research Company, Jupiter, FL, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schachtel Research Company, Jupiter, FL, USA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038307989","display_name":"Kathleen M. Sanner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathleen Sanner","raw_affiliation_strings":["Schachtel Research Company, Jupiter, FL, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schachtel Research Company, Jupiter, FL, USA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030443711","display_name":"Laurie Savino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laurie Savino","raw_affiliation_strings":["Schachtel Research Company, Jupiter, FL, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schachtel Research Company, Jupiter, FL, USA;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044680942","display_name":"Bernard P. Schachtel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernard Schachtel","raw_affiliation_strings":["Department of Epidemiology & Public Health, Yale University School of Medicine, New Haven, CT, USA","Schachtel Research Company, Jupiter, FL, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology & Public Health, Yale University School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Schachtel Research Company, Jupiter, FL, USA;","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5085088033"],"corresponding_institution_ids":["https://openalex.org/I4210115825","https://openalex.org/I4405268051"],"apc_list":null,"apc_paid":null,"fwci":1.2956,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.79443205,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"32","issue":"9","first_page":"1529","last_page":"1538"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.4758000075817108,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.4758000075817108,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12297","display_name":"Otolaryngology and Infectious Diseases","score":0.13950000703334808,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.04529999941587448,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flurbiprofen","display_name":"flurbiprofen","score":0.984000027179718},{"id":"https://openalex.org/keywords/lozenges","display_name":"lozenges","score":0.9789999723434448},{"id":"https://openalex.org/keywords/sore-throat","display_name":"sore throat","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tonsillitis","display_name":"tonsillitis","score":0.781000018119812},{"id":"https://openalex.org/keywords/pharyngitis","display_name":"pharyngitis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9369999766349792},{"id":"https://openalex.org/keywords/dysphagia","display_name":"dysphagia","score":0.996999979019165},{"id":"https://openalex.org/keywords/symptom-relief","display_name":"symptom relief","score":0.8299999833106995},{"id":"https://openalex.org/keywords/antibiotic-alternatives","display_name":"antibiotic alternatives","score":0.39399999380111694}],"concepts":[{"id":"https://openalex.org/C2777870961","wikidata":"https://www.wikidata.org/wiki/Q1292082","display_name":"Sore throat","level":2,"score":0.979605495929718},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.952061653137207},{"id":"https://openalex.org/C2781000538","wikidata":"https://www.wikidata.org/wiki/Q419890","display_name":"Flurbiprofen","level":2,"score":0.8796510696411133},{"id":"https://openalex.org/C158245101","wikidata":"https://www.wikidata.org/wiki/Q13127755","display_name":"Lozenge","level":2,"score":0.8597396612167358},{"id":"https://openalex.org/C2776989088","wikidata":"https://www.wikidata.org/wiki/Q16364","display_name":"Throat","level":2,"score":0.8409910798072815},{"id":"https://openalex.org/C2779279270","wikidata":"https://www.wikidata.org/wiki/Q2085267","display_name":"Pharyngitis","level":2,"score":0.6942982077598572},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5472190380096436},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5265291929244995},{"id":"https://openalex.org/C2910715184","wikidata":"https://www.wikidata.org/wiki/Q2085267","display_name":"Acute Pharyngitis","level":3,"score":0.5147985816001892},{"id":"https://openalex.org/C112497637","wikidata":"https://www.wikidata.org/wiki/Q211669","display_name":"Swallowing","level":2,"score":0.4810631275177002},{"id":"https://openalex.org/C2776752453","wikidata":"https://www.wikidata.org/wiki/Q174778","display_name":"Pharynx","level":2,"score":0.4548015594482422},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3481329083442688},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30005791783332825},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005480","descriptor_name":"Flurbiprofen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005480","descriptor_name":"Flurbiprofen","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005480","descriptor_name":"Flurbiprofen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010612","descriptor_name":"Pharyngitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/03007995.2016.1187119","doi":"https://doi.org/10.1080/03007995.2016.1187119","is_oa":false,"landing_page_url":"https://doi.org/10.1080/03007995.2016.1187119","pdf_url":null,"source":{"id":"https://openalex.org/S206643269","display_name":"Current Medical Research and Opinion","issn_l":"0300-7995","issn":["0300-7995","1473-4877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Research and Opinion","raw_type":"journal-article"},{"id":"pmid:27146963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27146963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current medical research and opinion","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W149883271","https://openalex.org/W163685968","https://openalex.org/W1814063348","https://openalex.org/W1900386570","https://openalex.org/W1966506035","https://openalex.org/W1973973711","https://openalex.org/W1976637818","https://openalex.org/W1980122017","https://openalex.org/W1989092099","https://openalex.org/W1998878236","https://openalex.org/W1999656621","https://openalex.org/W2000387984","https://openalex.org/W2022179248","https://openalex.org/W2031891196","https://openalex.org/W2037016050","https://openalex.org/W2045231356","https://openalex.org/W2054205981","https://openalex.org/W2073017111","https://openalex.org/W2073701354","https://openalex.org/W2081703605","https://openalex.org/W2085187731","https://openalex.org/W2098510062","https://openalex.org/W2100713052","https://openalex.org/W2101055539","https://openalex.org/W2107533173","https://openalex.org/W2112492031","https://openalex.org/W2123526961","https://openalex.org/W2146602654","https://openalex.org/W2158939557","https://openalex.org/W2166192746","https://openalex.org/W2168688512","https://openalex.org/W2183161336","https://openalex.org/W2329781423","https://openalex.org/W4250348758","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7073707949","https://openalex.org/W2073701354","https://openalex.org/W163685968","https://openalex.org/W2602761888","https://openalex.org/W2042757356","https://openalex.org/W2464870994","https://openalex.org/W3178202665","https://openalex.org/W4417198259","https://openalex.org/W2733730458","https://openalex.org/W149883271"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Sore":[1],"throat":[2,36,82,117,150,181,187,223,271],"is":[3,10,293],"often":[4,38],"over-treated":[5],"with":[6,66,79,157,242,274,284],"antibiotics,":[7],"therefore":[8],"there":[9],"a":[11,32,44,67,88,125,146,275,303],"need":[12],"for":[13],"non-antibiotic":[14],"treatments":[15],"that":[16],"provide":[17,260],"effective":[18],"relief.":[19],"From":[20],"the":[21,40,55,122,174,309],"patient's":[22],"point":[23],"of":[24,27,59,85,124,138,193,264,290,306],"view,":[25],"symptoms":[26,115],"pharyngeal":[28],"inflammation":[29],"such":[30],"as":[31,103,153,155,201,280,282],"\"swollen\"":[33],"and":[34,57,69,83,112,121,148,185,203,219,227,269,277],"\"inflamed\"":[35],"are":[37,298],"considered":[39],"most":[41],"bothersome;":[42],"so,":[43],"non-steroidal":[45],"anti-inflammatory":[46],"drug":[47],"could":[48],"be":[49],"an":[50],"appropriate":[51],"treatment.":[52],"We":[53,76],"investigated":[54],"efficacy":[56,137],"safety":[58],"flurbiprofen":[60,94,139],"8.75":[61,95,255],"mg":[62,96,256],"lozenge":[63,140,257],"in":[64,109,143,178,240,272],"adults":[65,78,273],"swollen":[68,126,147,186,202,228,270,276],"inflamed":[70,149,204,278],"throat.":[71],"RESEARCH":[72],"DESIGN":[73],"AND":[74],"METHODS:":[75],"enrolled":[77],"moderate-to-severe":[80],"sore":[81,180,222,265],"evidence":[84],"tonsillo-pharyngitis":[86],"into":[87],"randomized,":[89],"double-blind":[90],"study.":[91],"Patients":[92],"received":[93],"or":[97,248],"placebo":[98,213],"lozenges":[99,108,208],"every":[100],"3-6":[101],"hours":[102],"needed":[104],"(up":[105],"to":[106,259],"five":[107],"24":[110,134,189,215],"hours)":[111],"rated":[113],"their":[114,199],"(sore":[116],"pain,":[118,182,224],"difficulty":[119,183,225,267],"swallowing":[120,184,226,268],"sensation":[123],"throat)":[127],"on":[128],"standard":[129],"linear":[130],"scales":[131],"regularly":[132],"over":[133,188,214],"hours.":[135,190],"The":[136,169],"was":[141],"determined":[142],"patients":[144,241],"reporting":[145],"at":[151,205],"baseline,":[152],"well":[154,281],"those":[156,283],"relatively":[158,243,285],"severe":[159,244,286],"symptoms.":[160,245,287],"CLINICAL":[161],"TRIAL":[162],"REGISTRATION:":[163],"ClinicalTrials.gov":[164],"NCT01049334.":[165],"MAIN":[166],"OUTCOME":[167],"MEASURES:":[168],"main":[170],"outcome":[171],"measures":[172],"were":[173,237],"time-weighted":[175],"summed":[176],"differences":[177],"patient-reported":[179],"RESULTS:":[191],"Out":[192],"204":[194],"patients,":[195,307],"124":[196],"(60.8%)":[197],"described":[198],"throats":[200],"baseline.":[206],"Flurbiprofen":[207,254],"provided":[209],"greater":[210],"relief":[211,263],"than":[212],"hours:":[216],"79.8%,":[217],"99.6%":[218],"69.3%":[220],"(for":[221],"throat,":[229,266,279],"respectively,":[230],"all":[231],"P":[232],"\u2264":[233],"0.01).":[234],"These":[235],"outcomes":[236,300],"more":[238],"substantial":[239],"No":[246],"serious":[247],"unexpected":[249],"adverse":[250],"events":[251],"occurred.":[252],"CONCLUSIONS:":[253],"appears":[258],"effective,":[261],"well-tolerated":[262],"A":[288],"limitation":[289],"these":[291,297],"findings":[292],"that,":[294],"while":[295],"predetermined,":[296],"secondary":[299],"derived":[301],"from":[302],"targeted":[304],"sub-group":[305],"not":[308],"entire":[310],"study":[311],"population.":[312]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}