{"id":"https://openalex.org/W2402425702","doi":null,"title":"[Effects of erythromycin on surfactant synthesis, secretion, and recycling by rat alveolar type II cells].","display_name":"[Effects of erythromycin on surfactant synthesis, secretion, and recycling by rat alveolar type II cells].","publication_year":1996,"publication_date":"1996-10-01","ids":{"openalex":"https://openalex.org/W2402425702","mag":"2402425702","pmid":"https://pubmed.ncbi.nlm.nih.gov/8953904"},"language":"ja","primary_location":{"id":"pmid:8953904","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8953904","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Kyobu Shikkan Gakkai zasshi","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108387136","display_name":"Akira Suwabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I112524849","display_name":"Yamagata University","ror":"https://ror.org/00xy44n04","country_code":"JP","type":"education","lineage":["https://openalex.org/I112524849"]},{"id":"https://openalex.org/I4210165438","display_name":"Yamagata University Hospital","ror":"https://ror.org/05gg4qm19","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210165438"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A Suwabe","raw_affiliation_strings":["Department of Laboratory Medicine, Yamagata University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Yamagata University School of Medicine","institution_ids":["https://openalex.org/I112524849","https://openalex.org/I4210165438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103438903","display_name":"Miyuki Ito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I112524849","display_name":"Yamagata University","ror":"https://ror.org/00xy44n04","country_code":"JP","type":"education","lineage":["https://openalex.org/I112524849"]},{"id":"https://openalex.org/I4210165438","display_name":"Yamagata University Hospital","ror":"https://ror.org/05gg4qm19","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210165438"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Ito","raw_affiliation_strings":["Department of Laboratory Medicine, Yamagata University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Yamagata University School of Medicine","institution_ids":["https://openalex.org/I112524849","https://openalex.org/I4210165438"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101457926","display_name":"Keiji Takahashi","orcid":"https://orcid.org/0000-0001-7209-6708","observed_orcids":["https://orcid.org/0000-0001-7209-6708","https://orcid.org/0009-0002-1818-4920"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Takahashi","raw_affiliation_strings":["Division of Respiratory Disease, Department of Internal Medicine, Kanazawa Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Respiratory Disease, Department of Internal Medicine, Kanazawa Medical University","institution_ids":["https://openalex.org/I16568816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"10","first_page":"1104","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.019200000911951065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11356","display_name":"Pleural and Pulmonary Diseases","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythromycin","display_name":"erythromycin","score":1.0},{"id":"https://openalex.org/keywords/pulmonary-surfactant","display_name":"pulmonary surfactant","score":0.9850000143051147},{"id":"https://openalex.org/keywords/alveolar-type-ii-cells","display_name":"alveolar type II cells","score":0.8949999809265137},{"id":"https://openalex.org/keywords/surfactant-secretion","display_name":"surfactant secretion","score":0.9369999766349792},{"id":"https://openalex.org/keywords/surfactant-synthesis","display_name":"surfactant synthesis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/surfactant-recycling","display_name":"surfactant recycling","score":0.9409999847412109},{"id":"https://openalex.org/keywords/phosphatidylcholine","display_name":"phosphatidylcholine","score":0.9570000171661377},{"id":"https://openalex.org/keywords/lamellar-bodies","display_name":"lamellar bodies","score":0.9710000157356262},{"id":"https://openalex.org/keywords/pulmonary-alveolar-proteinosis","display_name":"pulmonary alveolar proteinosis","score":0.902999997138977},{"id":"https://openalex.org/keywords/macrolide-antibiotics","display_name":"macrolide antibiotics","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.9343900680541992},{"id":"https://openalex.org/C2780206985","wikidata":"https://www.wikidata.org/wiki/Q213511","display_name":"Erythromycin","level":3,"score":0.8370565176010132},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.7859192490577698},{"id":"https://openalex.org/C145156650","wikidata":"https://www.wikidata.org/wiki/Q4253549","display_name":"Lamellar granule","level":3,"score":0.7812174558639526},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.6911314129829407},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.419423371553421},{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.419242262840271},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.4059872627258301},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3243219256401062},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3093186616897583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2667723298072815},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.21451574563980103},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0694412887096405}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004917","descriptor_name":"Erythromycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011663","descriptor_name":"Pulmonary Surfactants","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011663","descriptor_name":"Pulmonary Surfactants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8953904","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8953904","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon Kyobu Shikkan Gakkai zasshi","raw_type":"Journal Article"},{"id":"mag:2402425702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8953904","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1484814483","https://openalex.org/W1613380815","https://openalex.org/W1943694755","https://openalex.org/W1968896133","https://openalex.org/W1989159174","https://openalex.org/W2026606228","https://openalex.org/W2114094740","https://openalex.org/W2152311269","https://openalex.org/W2331089332","https://openalex.org/W2410788213"],"related_works":["https://openalex.org/W2007757811","https://openalex.org/W1989159174","https://openalex.org/W2055211202","https://openalex.org/W2287806644","https://openalex.org/W7097693100","https://openalex.org/W2013620556","https://openalex.org/W2406109499","https://openalex.org/W2014205077","https://openalex.org/W3036640741","https://openalex.org/W2776699165"],"abstract_inverted_index":{"Effects":[0],"of":[1,31,39,61,81,116],"erythromycin":[2,90,126,137],"on":[3],"surfactant":[4,98,117,128],"synthesis,":[5],"secretion,":[6],"and":[7,25,41,103,134],"recycling":[8,115],"by":[9,118],"rat":[10,23],"alveolar":[11,146],"type":[12,119,131],"II":[13,18,86,120,132],"cells":[14,19,87],"were":[15,20],"examined.":[16],"Type":[17,85],"isolated":[21],"from":[22,36,42,58,74,130],"lungs":[24],"incubated":[26,88],"with":[27,51,89],"3H-choline,":[28],"a":[29],"precursor":[30],"surfactant.":[32],"Synthesis":[33],"was":[34,56,72],"quantified":[35,57,73],"the":[37,43,59,66,75],"amount":[38],"3H-phosphatidylcholine":[40,63],"distribution":[44],"to":[45,101],"lamellar":[46],"body":[47],"fractions":[48],"as":[49,145],"measured":[50],"sucrose":[52],"density":[53],"gradients.":[54],"Secretion":[55],"percent":[60,76],"synthesized":[62],"released":[64],"into":[65],"medium":[67],"over":[68,78],"3":[69],"hr.":[70],"Recycling":[71],"uptake":[77],"1":[79],"h":[80],"3H-labeled":[82],"synthetic":[83],"liposomes.":[84],"(5-50":[91],"micrograms/ml)":[92],"for":[93],"22":[94],"hrs":[95],"secreted":[96],"less":[97],"in":[99,141],"response":[100],"PMA":[102],"ATP":[104],"than":[105],"did":[106,110],"control":[107],"cells.":[108,121],"Erythromycin":[109],"not":[111],"affect":[112],"synthesis":[113],"or":[114],"These":[122],"results":[123],"show":[124],"that":[125,136],"inhibits":[127],"secretion":[129],"cells,":[133],"suggest":[135],"may":[138],"be":[139],"effective":[140],"surfactant-excess":[142],"states":[143],"such":[144],"proteinosis.":[147]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
