{"id":"https://openalex.org/W2402386972","doi":null,"title":"Influence of HIV-1 infection and cigarette smoking on leukocyte profiles in homosexual men. The Multicenter AIDS Cohort Study.","display_name":"Influence of HIV-1 infection and cigarette smoking on leukocyte profiles in homosexual men. The Multicenter AIDS Cohort Study.","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2402386972","mag":"2402386972","pmid":"https://pubmed.ncbi.nlm.nih.gov/1403643"},"language":"en","primary_location":{"id":"pmid:1403643","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1403643","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of acquired immune deficiency syndromes","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028845595","display_name":"L. P. Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L P Park","raw_affiliation_strings":["Johns Hopkins School of Public Health, Baltimore, MD 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins School of Public Health, Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012245215","display_name":"Joseph B. Margolick","orcid":"https://orcid.org/0000-0002-4210-9093","observed_orcids":["https://orcid.org/0000-0002-4210-9093"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J B Margolick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114249887","display_name":"Giorgi Jv","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J V Giorgi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073201628","display_name":"John Ferbas","orcid":"https://orcid.org/0000-0003-4087-4629","observed_orcids":["https://orcid.org/0000-0003-4087-4629"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Ferbas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"K Bauer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Bauer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111888490","display_name":"RA Kaslow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Kaslow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5010622215","display_name":"\u00c1lvaro Mu\u00f1oz","orcid":"https://orcid.org/0000-0002-4037-0490","observed_orcids":["https://orcid.org/0000-0002-4037-0490"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Mu\u00f1oz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2286,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.47698165,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"5","issue":"11","first_page":"1124","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.03680000081658363,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.025100000202655792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-infection","display_name":"HIV-1 infection","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cigarette-smoking","display_name":"cigarette smoking","score":0.9950000047683716},{"id":"https://openalex.org/keywords/leukocyte-profile","display_name":"leukocyte profile","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hiv-seroconversion","display_name":"HIV seroconversion","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/leukocytosis","display_name":"leukocytosis","score":0.8130000233650208},{"id":"https://openalex.org/keywords/differential-leukocyte-count","display_name":"differential leukocyte count","score":0.6869999766349792},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.8169999718666077},{"id":"https://openalex.org/keywords/gay-men","display_name":"gay men","score":0.7710000276565552}],"concepts":[{"id":"https://openalex.org/C2779898580","wikidata":"https://www.wikidata.org/wiki/Q6934593","display_name":"Multicenter AIDS Cohort Study","level":5,"score":0.9262735843658447},{"id":"https://openalex.org/C2777451964","wikidata":"https://www.wikidata.org/wiki/Q2141450","display_name":"Seroconversion","level":3,"score":0.8682613372802734},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7061011791229248},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6700185537338257},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.6486339569091797},{"id":"https://openalex.org/C2778923028","wikidata":"https://www.wikidata.org/wiki/Q974869","display_name":"Leukocytosis","level":2,"score":0.601341187953949},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4973035156726837},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4748920500278473},{"id":"https://openalex.org/C2778488018","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"White blood cell","level":2,"score":0.46384719014167786},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41083407402038574},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.355817973613739},{"id":"https://openalex.org/C2776452011","wikidata":"https://www.wikidata.org/wiki/Q311463","display_name":"Sida","level":4,"score":0.3315408527851105},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.2605323791503906},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1722557246685028}],"mesh":[{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004306","descriptor_name":"Dose-Response Relationship, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006716","descriptor_name":"Homosexuality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016131","descriptor_name":"Lymphocyte Subsets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016516","descriptor_name":"CD4-CD8 Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1403643","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1403643","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of acquired immune deficiency syndromes","raw_type":"Journal Article"},{"id":"mag:2402386972","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1403643","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4318964038","https://openalex.org/W2070505812","https://openalex.org/W216669560","https://openalex.org/W7096705828","https://openalex.org/W2133580961","https://openalex.org/W2030998750","https://openalex.org/W2410749440","https://openalex.org/W93538641","https://openalex.org/W7009102358","https://openalex.org/W2033875947"],"abstract_inverted_index":{"The":[0],"interaction":[1],"between":[2],"the":[3,21,97,134,144,169,172,187,198],"effects":[4,95,188],"of":[5,72,75,99,146,171,174,189,201,206],"HIV-1":[6,18,104,214],"infection":[7],"and":[8,40,80,82,87,130,137,160],"cigarette":[9,63],"smoking":[10,41,91,147,190],"on":[11,96,148],"leukocyte":[12,202],"profiles":[13],"was":[14,106],"studied":[15],"in":[16,20,58,112,119,126,133,157,197,209],"307":[17],"seroconverters":[19],"Multicenter":[22],"AIDS":[23],"Cohort":[24],"Study":[25],"(MACS).":[26],"Longitudinal":[27],"data":[28],"for":[29,46,216],"white":[30],"blood":[31],"cell":[32,38,150],"(WBC)":[33],"counts,":[34],"WBC":[35,55,76],"differentials,":[36],"T":[37],"subsets,":[39],"behavior":[42],"were":[43],"collected":[44],"semiannually":[45],"up":[47],"to":[48,52,61,180,194],"7":[49],"years.":[50,220],"Prior":[51],"seroconversion,":[53],"total":[54,127],"count":[56],"increased":[57],"direct":[59],"proportion":[60],"daily":[62],"consumption,":[64],"but":[65],"this":[66],"effect":[67,145],"disappeared":[68],"within":[69],"3":[70,164,219],"years":[71,165],"seroconversion.":[73,167],"Analyses":[74],"subsets":[77,84],"(lymphocytes,":[78],"monocytes,":[79],"granulocytes)":[81],"lymphocyte":[83,114,121,128,136],"(CD4+,":[85],"CD8+":[86,120],"non-T[CD3-])":[88],"showed":[89],"that":[90,143,186],"had":[92],"only":[93],"minor":[94],"proportions":[98],"these":[100],"cells.":[101],"In":[102],"contrast,":[103],"seroconversion":[105,178],"associated":[107],"with":[108],"a":[109,116,123],"dramatic":[110],"decrease":[111],"CD4+":[113],"percentage,":[115,122,129],"large":[117],"increase":[118,125],"small":[124,131],"decreases":[132],"non-T":[135],"granulocyte":[138],"percentages.":[139],"These":[140],"findings":[141],"indicate":[142],"CD4":[149,207],"counts":[151],"is":[152],"(a)":[153],"nonspecific,":[154],"(b)":[155],"maximal":[156],"seronegative":[158],"individuals;":[159],"(c)":[161],"lost":[162],"by":[163],"after":[166,177],"Although":[168],"mechanism":[170],"loss":[173],"smoking-induced":[175],"leukocytosis":[176],"remains":[179],"be":[181,195],"determined,":[182],"our":[183],"results":[184],"suggest":[185],"are":[191],"not":[192],"likely":[193],"important":[196],"clinical":[199],"use":[200],"measurements,":[203],"including":[204],"measurements":[205],"lymphocytes,":[208],"individuals":[210],"who":[211],"have":[212],"been":[213],"seropositive":[215],"more":[217],"than":[218]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}