{"id":"https://openalex.org/W2402267640","doi":null,"title":"Glutamate transporters of blood platelets as potential peripheral markers to analyze changes of glutamate transport activity in brain under altered gravity conditions.","display_name":"Glutamate transporters of blood platelets as potential peripheral markers to analyze changes of glutamate transport activity in brain under altered gravity conditions.","publication_year":2007,"publication_date":"2007-07-01","ids":{"openalex":"https://openalex.org/W2402267640","mag":"2402267640","pmid":"https://pubmed.ncbi.nlm.nih.gov/18372710"},"language":"en","primary_location":{"id":"pmid:18372710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18372710","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082960233","display_name":"\u0422atiana Borisova","orcid":"https://orcid.org/0000-0002-6533-1420","observed_orcids":["https://orcid.org/0000-0002-6533-1420"]},"institutions":[{"id":"https://openalex.org/I4210148994","display_name":"Palladin Institute of Biochemistry","ror":"https://ror.org/05hatwc22","country_code":"UA","type":"facility","lineage":["https://openalex.org/I149851306","https://openalex.org/I4210148994"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Tatiana Borisova","raw_affiliation_strings":["Dpt. of Neurochemistry, Palladin Institute of Biochemistry, NAS of Ukraine, Leontovicha str. 9, 01601 Kiev, Ukraine. tborisov@biochem.kiev.ua"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dpt. of Neurochemistry, Palladin Institute of Biochemistry, NAS of Ukraine, Leontovicha str. 9, 01601 Kiev, Ukraine. tborisov@biochem.kiev.ua","institution_ids":["https://openalex.org/I4210148994"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036361896","display_name":"L.A. Kasatkina","orcid":"https://orcid.org/0000-0003-3935-5389","observed_orcids":["https://orcid.org/0000-0003-3935-5389"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ludmila Kasatkina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2275,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.47538132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"14","issue":"1","first_page":"P81","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.4771000146865845,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.4771000146865845,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.43479999899864197,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.06989999860525131,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutamate-transporters","display_name":"glutamate transporters","score":0.9739999771118164},{"id":"https://openalex.org/keywords/platelets","display_name":"platelets","score":0.9549999833106995},{"id":"https://openalex.org/keywords/synaptosomes","display_name":"synaptosomes","score":0.7020000219345093},{"id":"https://openalex.org/keywords/glutamate-uptake","display_name":"glutamate uptake","score":0.7609999775886536},{"id":"https://openalex.org/keywords/altered-gravity","display_name":"altered gravity","score":0.7269999980926514},{"id":"https://openalex.org/keywords/microgravity","display_name":"microgravity","score":0.859000027179718},{"id":"https://openalex.org/keywords/sodium-dependence","display_name":"sodium dependence","score":0.6370000243186951},{"id":"https://openalex.org/keywords/peripheral-biomarkers","display_name":"peripheral biomarkers","score":0.7419999837875366},{"id":"https://openalex.org/keywords/transporter-kinetics","display_name":"transporter kinetics","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.8606323003768921},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.6833748817443848},{"id":"https://openalex.org/C113657865","wikidata":"https://www.wikidata.org/wiki/Q5419641","display_name":"Excitatory amino-acid transporter","level":4,"score":0.6707104444503784},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6512192487716675},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4996919631958008},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.46580085158348083},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4384710192680359},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34106212854385376},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08948767185211182},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08148905634880066},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07908323407173157}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013574","descriptor_name":"Synaptosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018470","descriptor_name":"Gravity, Altered","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050491","descriptor_name":"Glutamate Plasma Membrane Transport Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D050491","descriptor_name":"Glutamate Plasma Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:18372710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18372710","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W222749639","https://openalex.org/W2089227889","https://openalex.org/W1979207531","https://openalex.org/W1983388523","https://openalex.org/W2064561383","https://openalex.org/W1609177275","https://openalex.org/W2049398677","https://openalex.org/W2093570500","https://openalex.org/W2414573390","https://openalex.org/W2060964853"],"abstract_inverted_index":{"Activity":[0],"of":[1,28,45,50,68,96,103,140],"high-affinity":[2],"glutamate":[3,18,58,97,115,141],"transporters":[4,19,98],"was":[5,31,72,79,111,118],"altered":[6,147],"in":[7,37,99,105,144],"brain":[8,145],"nerve":[9,108],"terminals":[10],"under":[11,146],"artificial":[12],"gravity":[13,148],"conditions.":[14,149],"Blood":[15],"platelets":[16,63,84,104,131],"contain":[17],"and":[20,39,48,62],"are":[21],"able":[22],"to":[23,32,91,129,137],"uptake":[24,59,71,116],"glutamate.":[25],"The":[26,42],"goal":[27],"the":[29,57,69,100,114],"research":[30],"analyze":[33,138],"comparatively":[34],"L-[14C]glutamate":[35,70],"transport":[36,142],"neuronal":[38],"non-neuronal":[40],"tissues.":[41],"kinetic":[43],"characteristics":[44],"transporters,":[46],"[Na+]-dependence":[47],"influence":[49],"competitive":[51],"transporter":[52],"inhibitor":[53],"DL-threo-beta-hydroxyaspartate":[54],"(DL-THA)":[55],"on":[56],"by":[60],"synaptosomes":[61],"were":[64],"determined.":[65],"Km":[66],"value":[67],"very":[73],"similar":[74,120],"for":[75,83,121],"preparations.":[76],"Controversy,":[77],"Vmax":[78],"three":[80],"orders":[81],"lower":[82],"as":[85,132],"compared":[86],"with":[87,93,107],"synaptosomes.":[88],"It":[89,110],"seems":[90],"correlate":[92],"reduced":[94],"number":[95],"plasma":[101],"membrane":[102],"comparison":[106],"terminals.":[109],"concluded":[112],"that":[113],"process":[117],"primarily":[119],"both":[122],"objects":[123],"studied.":[124],"Thus,":[125],"it":[126],"is":[127],"reasonable":[128],"use":[130],"potential":[133],"peripheral":[134],"diagnostic":[135],"markers":[136],"changes":[139],"activity":[143]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}